Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence

NeuroImage ◽  
2013 ◽  
Vol 70 ◽  
pp. 10-20 ◽  
Author(s):  
Jeff Kershaw ◽  
Christoph Leuze ◽  
Ichio Aoki ◽  
Takayuki Obata ◽  
Iwao Kanno ◽  
...  
Keyword(s):  
Rat Brain ◽  
Diffusion Tensor ◽  
Spin Echo ◽  
Spin Echo Sequence ◽  
Apparent Diffusion

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

The effect of microvascular obstruction on the myocardial microstructure: a diffusion tensor imaging study

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Das ◽  
K Kelly ◽  
M Aldred ◽  
I Teh ◽  
CK Stoeck ◽  
...  
Keyword(s):  
Microvascular Obstruction ◽  
Diffusion Tensor ◽  
Spin Echo ◽  
Mean Diffusivity ◽  
Imaging Study ◽  
Free Breathing ◽  
Helix Angle ◽  
Acquisition Time ◽  
Heart Research

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Heart Research UK Background Diffusion tensor cardiac magnetic resonance (DT-CMR) imaging allows for characterising myocardial microstructure in-vivo using mean diffusivity (MD), fractional anisotropy (FA), secondary eigenvector angle (E2A) and helix angle (HA) maps. Following myocardial infarction (MI), alterations in MD, FA and HA proportions have previously been reported. E2A depicts the contractile state of myocardial sheetlets, however the behaviour of E2A in infarct segments, and all DTI markers in areas of microvascular obstruction (MVO) is also not fully understood.  Purpose We performed spin echo DTI in patients following ST-elevation MI (STEMI) in order to investigate acute changes in DTI parameters in remote and infarct segments both with and without MVO. Method Twenty STEMI patients (16 men, 4 women, mean age 59) had acute (5 ± 2d) 3T CMR scans. CMR protocol included: second order motion compensated (M012) free-breathing spin echo DTI (3 slices, 18 diffusion directions at b-values 100s/mm2[3], 200s/mm2[3] and 500s/mm2[12], reconstructed resolution was 1.66x1.66x8mm); cine and late gadolinium enhancement (LGE) imaging. Average MD, FA, E2A HA parameters were calculated on a  16 AHA segmental level. HA maps were described by dividing values into left-handed HA (LHM, -90° < HA < -30°), circumferential HA (CM, -30° < HA < 30°), and right-handed HA (RHM, 30° < HA < 90°) and reported as relative proportions. Segments were defined as infarct (positive for LGE) and remote (opposite to the infarct).  Results DTI acquisition was successful in all patients (acquisition time 13 ± 5mins). Ten patients had evidence of MVO on LGE images. MD was significantly higher in infarct regions in comparison to remote; MVO-ve infarct segments had significantly higher MD than MVO + ve infarct segments (MD remote= 1.46 ± 0.12x10-3mm2/s, MD MVO + ve = 1.59 ± 0.12x10-3mm2/s, MD MVO-ve  = 1.75 ± 0.12x10-3mm2/s, ANOVA p < 0.01). FA was reduced in infarct segments in comparison to remote; MVO-ve infarct segments had significantly lower FA than MVO + ve infarct segments (FAremote= 0.37 ± 0.02, FA MVO + ve = 0.31 ± 0.02 x 10-3mm2/s, MD MVO-ve =0.25 ± 0.02, ANOVA p < 0.01). E2A values were significantly lower in infarct segments compared to remote; MVO + ve infarct segments had significantly lower values than MVO-ve. (E2A remote= 57.4 ± 5.2°, E2A MVO-ve = 46.8 ± 2.5°, E2A MVO + ve = 36.8 ± 3.1°, ANOVA p < 0.001). RHM% (corresponding to subendocardium) was significantly lower in infarct segments compared to remote; MVO + ve infarct segments had significantly lower RHM% than MVO-ve. (RHM remote= 37 ± 3%, RHM RHM MVO-ve= 28 ± 7%, MVO + ve= 8 ± 5%, ANOVA p < 0.001). Conclusion The presence of MVO results in a decrease in MD and increase in FA in comparison to surrounding infarct segments. However, the reduction in E2A and right-handed myocytes on HA in infarct segments is further exacerbated by the presence of MVO. Further study is required to investigate the underlying mechanisms for such alterations in signal intensity. Abstract Figure. A case of transmural septal MI with MVO

In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI

2006 ◽  
Vol 24 (3) ◽  
pp. 287-293 ◽  
Author(s):  
Tomokazu Numano ◽  
Kazuhiro Homma ◽  
Nobuaki Iwasaki ◽  
Koji Hyodo ◽  
Naotaka Nitta ◽  
...  
Keyword(s):  
Rat Brain ◽  
Diffusion Tensor ◽  
Diffusion Weighted

Early postnatal development of rat brain: In vivo diffusion tensor imaging

2008 ◽  
Vol 86 (7) ◽  
pp. 1520-1528 ◽  
Author(s):  
K.H. Bockhorst ◽  
P.A. Narayana ◽  
R. Liu ◽  
P. Ahobila-Vijjula ◽  
J. Ramu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Rat Brain ◽  
Postnatal Development ◽  
Diffusion Tensor ◽  
Early Postnatal Development

scholarly journals Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

2013 ◽  
Vol 26 (6) ◽  
pp. 549-554 ◽  
Author(s):  
Lijing Xin ◽  
Giulio Gambarota ◽  
Cristina Cudalbu ◽  
Vladimír Mlynárik ◽  
Rolf Gruetter
Keyword(s):  
Rat Brain ◽  
Spin Echo ◽  
Relaxation Times ◽  
Single Spin ◽  
Cerebral Metabolites

scholarly journals Direct comparison of in-vivo and post-mortem spin-echo based diffusion tensor imaging in the porcine heart

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Christian T Stoeck ◽  
Constantin von Deuster ◽  
Nikola Cesarovic ◽  
Martin Genet ◽  
Maximilian Y Emmert ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Spin Echo ◽  
Post Mortem ◽  
Porcine Heart
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