Determinants of prognosis in patients with oral squamous cell carcinoma metastasizing to a single cervical lymph node

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects. Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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Expression of miRNA 21 in saliva & tumor tissue of Oral squamous cell carcinoma patients- A predictor of cervical lymph node metastasis.

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.07.012 ◽

2021 ◽

Author(s):

Kiran B. Jadhav ◽

Vandana Shah ◽

Nirali Chauhan ◽

Naveen Shah ◽

Ghanshyam Parmar

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Node ◽

Tumor Tissue ◽

Cervical Lymph Node Metastasis ◽

Node Metastasis

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Cervical Lymph Node Metastases in Oral Squamous Cell Carcinoma—How Much Imaging Do We Need?

Diagnostics ◽

10.3390/diagnostics10040199 ◽

2020 ◽

Vol 10 (4) ◽

pp. 199

Author(s):

Johannes Laimer ◽

Anke Lauinger ◽

Otto Steinmassl ◽

Vincent Offermanns ◽

Astrid E. Grams ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Metastases ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastases ◽

Study Results ◽

Node Metastases

Cervical lymph node metastases in oral squamous cell carcinoma (OSCC) are key predictors of disease specific survival. It was therefore the aim of this study to evaluate how much imaging is minimally needed for reliable and efficient identification of cervical lymph node metastases. In this retrospective cross-sectional study, results (metastasis yes/no) of ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) were compared to the final histopathological results of the corresponding neck dissection (ND) specimens (metastasis yes/no). A score was calculated to account for cervical lymph node size, shape, clustering, peripheral enhancement, hilus sign, architecture, blood flow, and central necrosis. Sensitivity and specificity were analyzed for each imaging technique separately. In 164 patients diagnosed with OSCC, 96 underwent uni- or bilateral ND (122 ND in total). One hundred percent sensitivity was achieved by CT+MRI, MRI+PET, US+CT+MRI, US+MRI+PET, CT+MRI+PET, and US+CT+MRI+PET. The highest specificity was realized by US with 79% (95% CI [0.698–0.890]). Specificity for CT+MRI and PET+MRI was 51% (95% CI [0.359–0.665]) and 70% (95% CI [0.416–0.984]), respectively. Regarding 100% sensitivity with acceptable specificity, the combination of CT+MRI or PET+MRI appeared to be suitable for staging cervical lymph nodes in primary OSCC.

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Association of Anneroth’s Scoring and Frequency of Cervical Lymph Node Metastasis among Primary Oral Squamous Cell Carcinoma Patients

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v6i2.42696 ◽

2019 ◽

Vol 6 (2) ◽

pp. 69-72

Author(s):

Mohammad Ahtashamul Haque ◽

Uday Kumar Goswami ◽

Md Mostafijur Rahman ◽

Mohammad Wahidul Islam ◽

Md Mahboob Morshed ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Primary Lesion ◽

Node Metastasis

Background: Primary Oral Squamous Cell Carcinoma can metastasize in the cervical lymph nodes. Objective: The purpose of the present study was to see the association of Anneroth’s scoring and frequency of cervical lymph node metastasis among primary oral squamous cell carcinoma patients. Methodology: This cross sectional study was conducted in the Department of Oral and Maxillofacial Surgery, Dhaka Dental College and Hospital, Dhaka, Bangladesh from November 2009 to December 2010 for a period of one year. Patients attending in the place of study with diagnosed case of oral squamous cell carcinoma were selected for the study after fulfilling the inclusion criteria. The resected primary lesion and neck lymph nodes were sent for histopathological examination. Histopathological grading of the primary lesion was done and neck lymphodes were graded as metastatic and non-metastatic. Results: This prospective study with 50 cases of oral squamous cell carcinoma was taken of which 28 cases were non-metastasis tumor. Each case was graded according to TNM classification, Broder’s grading and Anneroth’s classification. Both Anneroth’s classification (p=0.002) and Broder’s grading (p=0.017) were significant but Anneroth’s one was more significant than Broder’s. Conclusions: There is an association between Anneroth’s grading system with lymph node metastasis. Journal of Current and Advance Medical Research 2019;6(2): 69-72

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