The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105675
Author(s):  
Juncheng Wang ◽  
Yuxi Tian ◽  
Huimei Huang ◽  
Donghai Huang ◽  
Yong Liu ◽  
...  
Keyword(s):  
1993 ◽  
Vol 70 (5) ◽  
pp. 1759-1766 ◽  
Author(s):  
Y. I. Kim ◽  
W. J. Peacock ◽  
F. E. Dudek

1. Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques. The purposes of this study were to characterize the bursts evoked in immature human neocortical slices, to gain further insight to how N-methyl-D-aspartate (NMDA) and non-NMDA receptors contribute to the genesis of the bursts, and to determine whether the characteristics of the bursts were related to patient age or clinically defined abnormality of the tissue. 2. Epileptiform bursts evoked by focal stimulation of the underlying white or gray matter in bicuculline (10 microM) were all-or-none events. Once evoked, the bursts in a given neuron appeared very similar to one another, regardless of stimulus intensity. Stronger stimuli only decreased the onset latency of the bursts. The bursts evoked with relatively weak stimuli (< 2-3 times the threshold), particularly those from stimulation of a distant site (4-5 mm), were variable in onset latency. The bursts from stimulation of a close site (0.5-2 mm) with stronger stimuli (> 3 times the threshold) were invariable in onset latency. 3. Across different cells, particularly across the cells in different slices, the bursts were quite variable in terms of their morphology and duration. When measured at one-half of the amplitude of the underlying depolarization (approximately 20-50 mV), the duration of the bursts ranged from 20 to 775 ms (n = 80 cells). In 23% of the cases (18 of 80 cells), afterdischarges lasting for tens of milliseconds to a few seconds followed the bursts.(ABSTRACT TRUNCATED AT 250 WORDS)


2015 ◽  
Vol 92 (1083) ◽  
pp. 57-58 ◽  
Author(s):  
Partha Pratim Chakraborty ◽  
Sugata Narayan Biswas

2012 ◽  
Vol 3 (4) ◽  
pp. 192-197
Author(s):  
Helen Petersen

Oral bacteria have long been recognised as pathogens in distant site infections, most notably infective endocarditis (IE). Current changes in guidelines from the National Institute for Health and Clinical Excellence have highlighted the fact that these bacteria do not rely on a single surgical event to gain access to the vasculature and travel to the heart valves. Low grade, repetitive transient bacteraemia caused by everyday activities such as tooth brushing are thought to be more important in initiating IE. This article tells the story of the mechanisms by which oral commensal bacteria gain access to the vascular system to invade distant sites, including the heart valves.


Biochemistry ◽  
2004 ◽  
Vol 43 (41) ◽  
pp. 12990-12999 ◽  
Author(s):  
Laurie K. Jackson ◽  
Jeffrey Baldwin ◽  
Radha Akella ◽  
Elizabeth J. Goldsmith ◽  
Margaret A. Phillips

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