The place of pathology in a DVI response – exercise thanatos

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S24
Author(s):  
Scott Pearce
Keyword(s):  
Response Exercise

scholarly journals UUV's in Maritime Spill Response Exercise Cathach

2015 ◽  
Vol 48 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Gerard Dooly ◽  
Edin Omerdic ◽  
Joseph Coleman ◽  
Jośe Braga ◽  
Filipe Ferreira ◽  
...  
Keyword(s):  
Response Exercise

scholarly journals Ca2+sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries

2011 ◽  
Vol 300 (4) ◽  
pp. H1201-H1209 ◽  
Author(s):  
Juan Carlos Robles ◽  
Michael Sturek ◽  
Janet L. Parker ◽  
Cristine L. Heaps
Keyword(s):  
Exercise Training ◽  
Coronary Arteries ◽  
Contractile Function ◽  
Rho Kinase ◽  
Luminal Diameter ◽  
Contractile Responses ◽  
Endothelin 1 ◽  
Increased Sensitivity ◽  
Oxide Synthase ◽  
Response Exercise

Exercise training enhances endothelium-dependent coronary vasodilatation, improving perfusion and contractile function of collateral-dependent myocardium. Paradoxically, studies from our laboratory have revealed increased Ca2+-dependent basal active tone in collateral-dependent arteries of exercise-trained pigs. In this study, we tested the hypothesis that exercise training enhances agonist-mediated contractile responses of collateral-dependent arteries by promoting Ca2+sensitization. Ameroid constrictors were surgically placed around the proximal left circumflex coronary (LCX) artery of female Yucatan miniature pigs. Eight weeks postoperatively, pigs were randomized into sedentary (pen confined) or exercise-training (treadmill run; 5 days/wk; 14 wk) groups. Arteries (∼150 μm luminal diameter) were isolated from the collateral-dependent and nonoccluded (left anterior descending artery supplied) myocardial regions, and measures of contractile tension or simultaneous tension and intracellular free Ca2+concentration levels (fura-2) were completed. Exercise training enhanced contractile responses to endothelin-1 in collateral-dependent compared with nonoccluded arteries, an effect that was more pronounced in the presence of nitric oxide synthase inhibition ( Nω-nitro-l-arginine methyl ester; 100 μM). Contractile responses to endothelin-1 were not altered by coronary occlusion alone. Exercise training produced increased tension at comparable levels of intracellular free Ca2+concentration in collateral-dependent compared with nonoccluded arteries, indicative of exercise training-enhanced Ca2+sensitization. Inhibition of PKC (calphostin C; 1 μM), but not Rho-kinase (Y-27632, 10 μM; or hydroxyfasudil, 30 μM), abolished the training-enhanced endothelin-1-mediated contractile response. Exercise training also increased sensitivity to the PKC activator phorbol 12,13-dibutyrate in collateral-dependent compared with nonoccluded arteries. Taken together, these data reveal that exercise training enhances endothelin-1-mediated contractile responses in collateral-dependent coronary arteries likely via increased PKC-mediated Ca2+sensitization.

scholarly journals Implementation of Periop Disaster Response Exercise Program at Gold Coast Health

2019 ◽  
Vol 34 (s1) ◽  
pp. s81-s81
Author(s):  
Andrew Donohue ◽  
Tenzin Lamdark ◽  
Jo Lavin ◽  
Natalia Hupalo ◽  
Martin Wullschleger
Keyword(s):  
Disaster Response ◽  
Exercise Program ◽  
Mass Casualty ◽  
Gold Coast ◽  
University Hospital ◽  
Response Model ◽  
Clinical Environment ◽  
Disaster Plan ◽  
Preparation Phase ◽  
Response Exercise

Introduction:With the move into Gold Coast University Hospital, a new disaster plan was developed in 2017. To assess preparedness for the Commonwealth Games (April 2018), a number of mass casualty exercises were conducted, including a large multi-agency exercise with Queensland Police and Ambulance Services. During this preparation phase, senior clinicians from the perioperative area clarified their sub-plans and developed a novel model of periop response.Aim:This study assesses this model of response and evaluates it within the context of periop disaster exercises.Methods:The periop response model evolved through multi-disciplinary key stakeholder engagement into a defined model of surgical, anesthetic, and periop nursing responses with dedicated roles and parallel communication streams from ED to OR by the respective specialties. Throughout different disaster exercises, this model of response was tested, refined, and evaluated by formal post-exercise debriefs and group meetings.Results:Since May 2017, seven different mass casualty exercises with periop response were performed; firstly, a table-top (EmergoTrainSystem) format was used, which revealed communication and logistical deficiencies. After model refinement, further exercises were accomplished, all within the clinical environment, including movements of mock patients from ED to OR. These exercises generated improvements in communication, coordination, and logistics. Every exercise was also used to test more detailed information, communication, and organizational tasks of the various involved craft groups, such as notification, call-in lists, whiteboard structure, transport facilitation, and many more. Overall, our newly developed periop response model proved to be robust and successful, even with rotating personnel through different roles.Discussion:Apart from the success of the periop response model, other hospital areas (ICU, bed and ward management) became involved. With growing interest and staff turn-over a regular periop disaster response exercise program has now been established. This model of periop response has potential for use in other health systems.

THE NATIONAL PREPAREDNESS FOR RESPONSE EXERCISE PROGRAM (PREP) A PAPER TIGER OR DYNAMIC PROCESS?

2005 ◽  
Vol 2005 (1) ◽  
pp. 969-972
Keyword(s):  
Exercise Program ◽  
Lessons Learned ◽  
Incident Management ◽  
Hazardous Substance ◽  
Worst Case ◽  
Continuous Growth ◽  
Incident Command ◽  
Self Evaluation ◽  
National Preparedness ◽  
Response Exercise

ABSTRACT The National Preparedness for Response Exercise Program has been in effect for over a decade. There is no doubt that it has been a principal factor in moving the response community from the concept of developing incident management from scratch, to unified performance through organized teams. However, in the past couple of years the PREP approach has reached a certain level and stalled. When one goes to exercise design meetings throughout the country and commonly hear, “we are not ready to deal with this issue,” one must wonder why plans cannot or will not be fully tested after a decade of experience. Is the program working to the degree that is necessary and achievable? For continuous growth of the response community's level of competency in the Incident Command System and oil/hazardous substance response operations, a dynamic exercise program must exist. It is pertinent to ask?Has the National PREP Program reached status quo, and if so are we willing to change in order to improve?What is gained by testing the initial 24-hour period of the response over and over?Do core components of a plan tested during smaller exercises satisfy the effort that would be required for the Worst Case Discharge event?What works best, self-evaluation or independent evaluation?Is agency verification of exercises being done?Are unresolved issues and lessons learned documented, studied, and resolved before the next training or spill?Are lessons learned shared between companies for incorporation into plans?Do either the national or state modified PREP programs promote increased capability of oil spill removal organizations and spill management teams at local, regional, and national levels?Is the true availability of response resources tested through PREP? This paper will compare and contrast the National PREP program conducted by Federal Agencies, to the State of Washington's modified PREP program. The authors will answer these questions and provide recommendations for changes to PREP that will create a more dynamic and meaningful training program.

Designing, Executing, and Evaluating a U.S. Government-Led National Preparedness for Response Exercise Program (PREP) Drill

2003 ◽  
Vol 2003 (1) ◽  
pp. 597-602 ◽  
Author(s):  
Dennis Cashman ◽  
Jackie Stephens ◽  
LT Thomas Boyles
Keyword(s):  
Exercise Program ◽  
Lessons Learned ◽  
Initial Contact ◽  
Contact Phase ◽  
Production Phase ◽  
Execution Phase ◽  
Planning Cycle ◽  
Phase Coordination ◽  
National Preparedness ◽  
Response Exercise

ABSTRACT Planning, designing, and executing an area exercise in accordance with the National Preparedness for Response Exercise Program (PREP) Guidelines is an extensive time and resource undertaking. Since it's inception in 1991, the National Strike Force Coordination Center (NSFCC) has designed, updated and tested a successful exercise development process. This overview of the process outlines requirements necessary to manage a coordinated exercise development, execution, and follow up lessons learned. The process follows a 24-week cycle depending upon the needs of the organizations being exercised. The NSFCC must adhere to and follow the planning cycle because: at least three other government-led exercises are undergoing development at any given time; adequate time is needed for the Joint Design Team to plan effectively and provide the required data to the NSFCC; members of the Area Committee need time to accomplish their own exercise preparation processes; and time is needed to produce the exercise manuals and arrange logistics for personnel and equipment. The cycle is broken into six phases: the Initial Contact Phase, Coordination & Initial Production Phase, Interim Production Phase, Final Production Phase, Exercise Execution Phase, and Report Development Phase (Figure 1).

scholarly journals republic of Senegal disaster preparedness and response exercise

2016 ◽  
Vol 82 (3) ◽  
pp. 420
Author(s):  
P.L. Reed ◽  
J.D. Greulich ◽  
M.J. Hamer ◽  
C.W. Beadling
Keyword(s):  
Disaster Preparedness ◽  
Disaster Preparedness And Response ◽  
Response Exercise

Radioanalytical emergency response exercise

2006 ◽  
Vol 269 (2) ◽  
pp. 351-360 ◽  
Author(s):  
K. G. W. Inn ◽  
I. Outola ◽  
S. Nour ◽  
H. Kurosaki
Keyword(s):  
Emergency Response ◽  
Response Exercise
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