scholarly journals Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: potential pharmacological applications with mechanistic insight.

2021 ◽  
pp. 100206
Author(s):  
Dheeraj Bisht ◽  
Mohmmad Rashid ◽  
Rajeshwar Kamal Kant Arya ◽  
Deepak Kumar ◽  
Sushil Kumar Chaudhary ◽  
...  
Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 186 ◽  
Author(s):  
Luca Frattaruolo ◽  
Gabriele Carullo ◽  
Matteo Brindisi ◽  
Sarah Mazzotta ◽  
Luca Bellissimo ◽  
...  

Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH) or 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively. Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research.


Fitoterapia ◽  
2011 ◽  
Vol 82 (4) ◽  
pp. 546-556 ◽  
Author(s):  
Laura Siracusa ◽  
Antonella Saija ◽  
Mariateresa Cristani ◽  
Francesco Cimino ◽  
Manuela D'Arrigo ◽  
...  

2021 ◽  
Vol 6 (1) ◽  
pp. 1-13
Author(s):  
Ilaria Marotti ◽  
◽  
Francesca Truzzi ◽  
Camilla Tibaldi ◽  
Lorenzo Negri ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
LL Gauthier ◽  
C Simmler ◽  
DS Nikolic ◽  
R Van Breemen ◽  
SN Chen ◽  
...  

2020 ◽  
Vol 25 (2) ◽  
pp. 61-71
Author(s):  
Rajendra Gyawali ◽  
Rupesh Kumar Gupta ◽  
Sahana Shrestha ◽  
Rajendra Joshi ◽  
Prem Narayan Paudel

Alcoholic extracts of medicinal plants Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L, and Azadirachta indica A. Juss were subjected to the evaluation of antioxidant properties and combined for the cream formulation. The antioxidant property was determined by using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and inhibition of lipid peroxidase assays. The cream formulation was designed using Minitab software and a central composite design was used to study the effect of dependent variables, steric acid and cetyl alcohol on the response variables such as, viscosity, pH, and spreadability. The phytochemical screening of extracts showed the presence of tannin, phenol, flavonoids, saponins, and alkaloids. Antioxidant properties of the extracts and their relative composition were found variable. Composition F3 (C. zeylanicum Blume: G. glabra L: A. indica A. Juss; 01: 02: 01) possessed the highest antioxidant capacity compared to other ratios. The cream prepared from this composition was found stable for pH, viscosity as well as antioxidant activity under normal condition (25) and accelerated condition (40 ). The cream with DPPH scavenging activity of 93.86 % at 15 µg/mL (IC50 8.58±0.30) and lipid peroxidase assay 90.93 % at 200 µg/mL (IC50 72.30±0.60) with pH 5.50 was found with a non-Newtonian positive thixotropic flow property. Parameters like pH, viscosity, and spreadability of the cream were within the acceptance range, and found stable and permeable


2016 ◽  
Vol 5 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Aiyatullah Shah ◽  
Muzafar Ahmad Rather ◽  
Aabid Manzoor Shah ◽  
Saleem Mushtaq ◽  
Aehtesham Hussain ◽  
...  

1998 ◽  
Vol 34 (4) ◽  
pp. 331-334 ◽  
Author(s):  
S. R. Thengane ◽  
D. K. Kulkarni ◽  
K. V. Krishnamurthy

Sign in / Sign up

Export Citation Format

Share Document