EMT-related genes are unlikely to be involved in extracapsular growth of lymph node metastases in gastric cancer

2021 ◽  
pp. 153688
Elise Pretzsch ◽  
Christopher Lampert ◽  
Alexandr V. Bazhin ◽  
Helena Link ◽  
Sven Jacob ◽  
2011 ◽  
Vol 18 (8) ◽  
pp. 2265-2272 ◽  
Daniele Marrelli ◽  
Maria Antonietta Mazzei ◽  
Corrado Pedrazzani ◽  
Marianna Di Martino ◽  
Carla Vindigni ◽  

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14673-e14673
Luisa Quaresma ◽  
Antonio CALDEIRA Fradique ◽  
Fernanda Cabrita ◽  
Alexandra Pupo ◽  
Guedes DA Silva ◽  

e14673 Background: Lymph node Metastases play a major role as an independent prognostic factor in gastric cancer. Presence of distal lymph node metastases assumes a pejorative prognostic significance, and represents a problem in terms of therapeutic approach. For this reason it’s of major interest to find predictive markers of distal lymph node chain involvement. The P53 tumor suppressor gene, a product of the TP53 gene works normally as a brake on DNA replication, as suppressor of angiogenesis and triggering of apoptosis. The gene most frequently mutated in gastric cancer is the TP53, that is responsible for the production of P53 mutant protein, which forms inactive complex with the native protein, and manifest by the overexpression of p53 in immunocytochemistry. The overexpression of P53 gene has been considered a bad prognostic factor associated mainly with lymph node metastases. Methods: This study seeks to determine the relation between the expression of P53 and the presence of distal lymph node metastases as an indicator for an extended lymphadenectomy. A total of 50 patients undergoing surgery with D2 lymphadenectomy for gastric carcinoma with curative intent were enrolled in this work. Therefore it was evaluated in 1,786 lymph nodes the correlation between the P53 expression with tumor location, size, histological type, depth , number of nodes involved, number of distal lymph node metastases and the TNM stage. Results: In all parameters, mutant P53 protein related with indicators of poor prognosis. In particular has demonstrated a statistical significant correlation (p=0.019) with the presence of distal lymph node metastases. The main objective of this study which was finding a prognostic predictor of distal nodal metastases has been reached. Conclusions: Mutant P53 protein is a good prognostic indicator, for the presence of distal lymph node involvement in gastric carcinoma.

2006 ◽  
Vol 14 (31) ◽  
pp. 3060
Zhi-Qing Zhao ◽  
Ke-Guo Zheng ◽  
Jing-Xian Shen ◽  
Wei Wang ◽  
Zi-Ping Li ◽  

2000 ◽  
Vol 24 (12) ◽  
pp. 1550-1558 ◽  
Stefano Guadagni ◽  
Giovanni de Manzoni ◽  
Marco Catarci ◽  
Marco Valenti ◽  
Gianfranco Amicucci ◽  

Radiology ◽  
1995 ◽  
Vol 197 (3) ◽  
pp. 705-711 ◽  
T Fukuya ◽  
H Honda ◽  
T Hayashi ◽  
K Kaneko ◽  
Y Tateshi ◽  

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Mariusz Gryko ◽  
Anna Pryczynicz ◽  
Konrad Zareba ◽  
Bogusław Kędra ◽  
Andrzej Kemona ◽  

Background.Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence ofHelicobacter pyloriinfection, and patients’ survival.Materials and Methods.The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically.Results.Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancerP<0.05, with the intestinal type according to LaurenP<0.001, ulcerated type according to Bormann’s classificationP<0.01, and with local lymph node metastasesP<0.05.Conclusion.The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.

2019 ◽  
Vol 23 (2) ◽  
pp. 349-355 ◽  
Masahiro Yura ◽  
Takaki Yoshikawa ◽  
Sho Otsuki ◽  
Yukinori Yamagata ◽  
Shinji Morita ◽  

2014 ◽  
Vol 74 (2) ◽  
pp. 433-434 ◽  
Daniele Marrelli ◽  
Maria Antonietta Mazzei ◽  
Franco Roviello

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