scholarly journals Mucoepidermoid carcinoma of the lacrimal gland in a patient with the CRTC1-MAML2 fusion gene

2021 ◽  
Vol 16 (12) ◽  
pp. 3643-3646
Author(s):  
Kensaku Makino ◽  
Kei Nakajima ◽  
Satoshi Tsutsumi ◽  
Akane Toriyama ◽  
Senshu Nonaka ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma ◽  
Fusion Gene

scholarly journals Anaplastic Lymphoma Kinase-Positive Lung Cancer with Mucoepidermoid Carcinoma Differentiation: A Case Report

2020 ◽  
Vol 13 (2) ◽  
pp. 1037-1041
Author(s):  
Toshio Sakatani ◽  
Yoshio Masuda ◽  
Teppei Morikawa ◽  
Kazuhiro Usui
Keyword(s):  
Lung Cancer ◽  
Anaplastic Lymphoma Kinase ◽  
Mucoepidermoid Carcinoma ◽  
Fusion Gene ◽  
Clinical Stage ◽  
Lower Lobe ◽  
Egfr Mutations ◽  
Rare Tumor ◽  
Genetic Characteristics ◽  
Anaplastic Lymphoma

Mucoepidermoid carcinoma (MEC) of the lung is an extremely rare tumor, and a standard chemotherapy has not been established. Furthermore, little work has been conducted on the genetic characteristics of MEC. We herein report the case of a 42-year-old nonsmoking male patient who was referred to our hospital due to cough. Chest computed tomography demonstrated infiltration and atelectasis in the right lower lobe. He was eventually diagnosed with non-small cell lung cancer (NSCLC) with MEC differentiation corresponding to clinical stage IVA (cT4N2M1a[PLE]). Genetic testing for EGFR mutations was negative, but positive for anaplastic lymphoma kinase (ALK) fusion gene. After 2 weeks of first-line treatment with alectinib, the tumor decreased in size and his symptoms improved. Advanced MEC is a rare tumor, and reports on the treatment of ALK-positive NSCLC with MEC differentiation are rare.

Mucoepidermoid Carcinoma of the Lacrimal Gland Fossa

1989 ◽  
Vol 82 (5) ◽  
pp. 643-646 ◽  
Author(s):  
ANDREW W. LAWTON ◽  
JAMES W. KARESH
Keyword(s):  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma

scholarly journals Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

1989 ◽  
Vol 9 (2) ◽  
pp. 854-859 ◽  
Author(s):  
P J Tremblay ◽  
F Pothier ◽  
T Hoang ◽  
G Tremblay ◽  
S Brownstein ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Mammary Tumor ◽  
Lacrimal Gland ◽  
Mouse Mammary Tumor Virus ◽  
Fusion Gene ◽  
Ras Oncogene ◽  
Mammary Tumor Virus ◽  
Specific Effects ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.

scholarly journals High-grade Mucoepidermoid Carcinoma of the Lacrimal Gland

2018 ◽  
Vol 32 (5) ◽  
pp. 426
Author(s):  
Seok Jin Hwang ◽  
Keun Hae Kim
Keyword(s):  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma ◽  
High Grade

scholarly journals Low-Grade Mucoepidermoid Carcinoma of the Lacrimal Gland in a Teenaged Patient

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Ozgun Melike Gedar Totuk ◽  
Mustafa Kemal Demir ◽  
Ozlem Yapicier ◽  
Mert Mestanoglu
Keyword(s):  
Salivary Glands ◽  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma ◽  
Definitive Diagnosis ◽  
Preoperative Imaging ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Radiological Findings ◽  
Invasive Tumour ◽  
Complete Surgical Resection

Mucoepidermoid carcinoma is the most common malignant, locally invasive tumour of the salivary glands and accounts for approximately 35% of all malignancies of the major and minor salivary glands. Mucoepidermoid carcinoma that originated from the lacrimal gland is exceedingly rare in teenage patients, with only a few cases reported. Herein, we report clinical and radiological findings of a mucoepidermoid carcinoma arising from the lacrimal gland in a 15-year-old boy. We suggest that since preoperative imaging findings are not diagnostic for mucoepidermoid carcinoma, histopathologic examination should be performed for definitive diagnosis. Complete surgical resection is the treatment of choice for low-grade lacrimal gland mucoepidermoid carcinoma.

scholarly journals Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators

2021 ◽  
Author(s):  
Stijn van Weert ◽  
Birgit I. Lissenberg-Witte ◽  
Elisabeth Bloemena ◽  
C. René Leemans
Keyword(s):  
Head And Neck ◽  
Mucoepidermoid Carcinoma ◽  
Survival Benefit ◽  
Fusion Gene ◽  
Late Onset ◽  
Disease Free Survival ◽  
Distant Metastases ◽  
Distant Recurrence ◽  
Primary Diagnosis ◽  
Fish Analysis

Abstract Purpose Mucoepidermoid carcinoma (MEC) of the head and neck is a prevalent malignant salivary gland tumour with a reported good outcome. The aim of this study was to report the outcome in our centre. Methods A retrospective chart analysis with survival analyses was performed combined with fluorescence in situ hybridization (FISH) analysis to assess CRTC1/3 MAML 2 fusion gene presence. Results Sixty-four cases of MEC were identified. Median age at presentation was 51.4 years with a predominance for parotid gland involvement. Five, 10- and 20- year disease-free survival was 98%, 90% and 68%, respectively. Overall survival was 94%, 90% and 64%, respectively. Local recurrence was seen up to 14 years after primary diagnosis; distant metastases were diagnosed up to 17 years later. The overall recurrence rate was less than 20 per cent. CRTC1/3 MAML 2 fusion gene presence showed no survival benefit. Conclusion MEC of the head and neck has a favorable outcome with the exception of high-grade MEC. PNI and nodal involvement are not rare. CRTC1/3 MAML 2 fusion gene presence showed no survival benefit. The tendency for late onset of loco-regional and distant recurrence should not be underestimated.

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues

1989 ◽  
Vol 9 (2) ◽  
pp. 854-859
Author(s):  
P J Tremblay ◽  
F Pothier ◽  
T Hoang ◽  
G Tremblay ◽  
S Brownstein ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Mammary Tumor ◽  
Lacrimal Gland ◽  
Mouse Mammary Tumor Virus ◽  
Fusion Gene ◽  
Ras Oncogene ◽  
Mammary Tumor Virus ◽  
Specific Effects ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.

Mucoepidermoid Carcinoma of the Lacrimal Gland

Ophthalmology ◽  
1991 ◽  
Vol 98 (10) ◽  
pp. 1551-1555 ◽  
Author(s):  
Leonard A. Levin ◽  
Jerry Popham ◽  
King To ◽  
Ann Hein ◽  
John Shore ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma of the Lacrimal Gland

1993 ◽  
Vol 9 (3) ◽  
pp. 170-181 ◽  
Author(s):  
Joseph A. Eviatar ◽  
Albert Hornblass
Keyword(s):  
Lacrimal Gland ◽  
Mucoepidermoid Carcinoma
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