scholarly journals A case of malignant hypertension with multi-organ injury

2022 ◽  
Vol 17 (3) ◽  
pp. 455-461
Author(s):  
Ikuo Misumi ◽  
Mikiko Fukushima ◽  
Kuniyasu Wada ◽  
Joji Urata ◽  
Koji Sato ◽  
...  
Keyword(s):  
Malignant Hypertension ◽  
Organ Injury

Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis

Pneumologie ◽  
2014 ◽  
Vol 68 (S 01) ◽  
Author(s):  
H Müller-Redetzky ◽  
U Henke-Kellermann ◽  
T Tschernig ◽  
S Wienhold ◽  
M Polikarpova ◽  
...  
Keyword(s):  
Lung Injury ◽  
Pneumococcal Pneumonia ◽  
Complement Component ◽  
Organ Injury

Abnormal Haemostasis and Blood Viscosity in Malignant Hypertension

1984 ◽  
Vol 52 (03) ◽  
pp. 253-255 ◽  
Author(s):  
C Isles ◽  
G D O Lowe ◽  
B M Rankin ◽  
C D Forbes ◽  
N Lucie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Viscosity ◽  
Renal Damage ◽  
Antithrombin Iii ◽  
Plasma Viscosity ◽  
Malignant Hypertension ◽  
Fibrin Deposition ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

SummaryWe have previously shown abnormalities of haemostasis suggestive of intravascular coagulation in patients with malignant hypertension, a condition associated with retinopathy and renal fibrin deposition. To determine whether such abnormalities are specific to malignant hypertension, we have measured several haemostatic and haemorheological variables in 18 patients with malignant hypertension (Group 1), 18 matched healthy controls (Group 2), and 18 patients with non-malignant hypertension (Group 3) matched for renal pathology, blood pressure and serum creatinine with Group 1. Both Groups 1 and 3 had increased mean levels of fibrinogen, factor VIIIc, beta-thrombo- globulin, plasma viscosity and blood viscosity (corrected for haematocrit); and decreased mean levels of haematocrit, antithrombin III and platelet count. Mean levels of fast antiplasmin and alpha2-macroglobulin were elevated in Group 1 but not in Group 3. We conclude that most blood abnormalities are not specific to malignant hypertension; are also present in patients with non-malignant hypertension who have similar levels of blood pressure and renal damage; and might result from renal damage as well as promoting further renal damage by enhancing fibrin deposition. However increased levels of fibrinolytic inhibitors in malignant hypertension merit further investigation in relation to removal of renal fibrin.

Delayed Mesenteric Hematoma of the Sigmoid Colon Following Blunt Abdominal Trauma

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Motor Vehicle ◽  
Pelvic Fractures ◽  
Motor Vehicle Crash ◽  
Organ Injury ◽  
Contrast Extravasation ◽  
Body Fracture ◽  
Mesenteric Hematoma ◽  
Level I ◽  
Hispanic Male ◽  
Trauma Bay

A 25-year-old Hispanic male was transferred to our level I trauma center after being ejected 40 feet from a motor vehicle crash. Once stabilized in the trauma bay, a computed tomography (CT) scan of the abdomen/pelvis with IV contrast revealed two AAST Organ Injury Scale grade III liver lacerations without contrast extravasation, bilateral pulmonary contusions, right posterior non-displaced fourth rib fracture, non-displaced right scapular body fracture, and bilateral anterior and posterior pelvic fractures [Figures 1–2]. A non-operative approach to the hepatic lacerations was chosen and the patient underwent closed reduction and percutaneous pinning of his posterior pelvic fractures as well as anterior external fixation of his bilateral pubic rami fractures.

Malignant hypertension due to musculo-mucoid intimal hyperplasia of intrarenal arteries. Absence of renal fibrinoid necrosis.

1975 ◽  
Vol 36 (6) ◽  
pp. 133-144 ◽  
Author(s):  
J A Pitcock ◽  
J G Johnson ◽  
L Share ◽  
F E Hatch ◽  
S R Acchiardo ◽  
...  
Keyword(s):  
Intimal Hyperplasia ◽  
Malignant Hypertension ◽  
Fibrinoid Necrosis

Obesity as a risk factor in drug-induced organ injury

1989 ◽  
Vol 98 (1) ◽  
pp. 12-24 ◽  
Author(s):  
George B. Corcoran ◽  
Daniel E. Salazar ◽  
Hannah H. Chan
Keyword(s):  
Risk Factor ◽  
Organ Injury ◽  
Drug Induced

scholarly journals The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing
Keyword(s):  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Current Knowledge ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Histone Deacetylase 3 ◽  
Physiological Conditions ◽  
Inflammatory Conditions ◽  
Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

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