Earth friendly spectrophotometric methods based on different manipulation approaches for simultaneous determination of aspirin and omeprazole in binary mixture and pharmaceutical dosage form: Comparative statistical study

2022 ◽  
Vol 266 ◽  
pp. 120436
Author(s):  
Manal S. Elmasry ◽  
Wafaa S. Hassan ◽  
Magda Y. El-Mammli ◽  
Mohamed Badrawy
Keyword(s):  
Binary Mixture ◽  
Simultaneous Determination ◽  
Dosage Form ◽  
Statistical Study ◽  
Pharmaceutical Dosage Form ◽  
Spectrophotometric Methods

Simultaneous determination of methocarbamol and aspirin binary mixture in their combined tablets by derivative and ratio derivative spectrophotometry

2015 ◽  
Vol 7 (13) ◽  
pp. 5674-5681 ◽  
Author(s):  
M. Sharaf El-Din ◽  
M. Eid ◽  
Abdallah M. Zeid
Keyword(s):  
Binary Mixture ◽  
Simultaneous Determination ◽  
Dosage Form ◽  
Derivative Spectrophotometry ◽  
Spectrophotometric Methods ◽  
Ratio Derivative Spectrophotometry

Two simple and rapid spectrophotometric methods for the simultaneous determination of methocarbamol and aspirin in their combined dosage form.

Simultaneous determination of Sulphadoxine and Pyrimethamine by taking Tolterodine as an internal standard in Pharmaceutical dosage form by RP-HPLC

2021 ◽  
pp. 145-150
Author(s):  
Sushil D. Patil ◽  
Pravin B. Shelke ◽  
Priti Aher ◽  
Maswood Ahmed Hafizur Rahman
Keyword(s):  
Simultaneous Determination ◽  
Dosage Form ◽  
Internal Standard ◽  
Hplc Method ◽  
Control Analysis ◽  
Pharmaceutical Dosage Form ◽  
Quality Control Analysis ◽  
Rp Hplc ◽  
Sulphadoxine Pyrimethamine

A simple, rapid, economic, sensitive and precise HPLC method has been developed for the simultaneous determination of Sulphadoxine and Pyrimethamine in pharmaceutical dosage form by taking Tolterodine as an internal standard. The method was carried out using Phenomenex C18 (4.6ID × 250mm; 5µm) column and mobile phase comprised of methanol and Phosphate Buffer in proportion of ratio 60:40 v/v. The flow rate was 1.0mL/min and detection was carried out at 276nm. The retention time of Sulphadoxine, Pyrimethamine and Tolterodine were found to be 2.967, 4.058 and 6.908 respectively. Linearity of Sulphadoxine and Pyrimethamine in the range of 2 to 12μg/mL and 4 to 24μg/mL respectively. The % recoveries of Sulphadoxine and Pyrimethamine were found to be in between 99.93% to 99. 96 % respectively. The proposed method is suitable for the routine quality control analysis for simultaneous determination of Sulphadoxine and Pyrimethamine was in bulk and pharmaceutical dosage form.

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