Spectroscopic investigation of retinal degeneration unravel molecular changes associated with vision impairment

Author(s):  
Sherif S. Mahmoud ◽  
Eman S Al Abrak ◽  
Eman M. Aly ◽  
Marwa A. Fouly
2021 ◽  
Author(s):  
Michael Telias ◽  
Kevin Sit ◽  
Daniel Frozenfar ◽  
Benjamin Smith ◽  
Arjit Misra ◽  
...  

In degenerative retinal disorders, rod and cone photoreceptors die, causing vision impairment and blindness. Downstream neurons survive but undergo morphological and physiological remodeling, with some retinal ganglion cells (RGC) exhibiting heightened spontaneous firing. Retinoic acid (RA) has been implicated as the key signaling molecule that induces RGC hyperactivity, obscuring RGC light responses and reducing light avoidance behaviors triggered by residual rods and cones. However, evidence that RA-dependent remodeling corrupts image-forming vision has been lacking. Here we show that disulfiram, an FDA-approved drug that inhibits RA synthesis, and BMS 493, an RA receptor (RAR) inhibitor, reduce RGC hyperactivity and augment image detection in visually impaired mice. Functional imaging of visual cortical neurons shows that disulfiram and BMS 493 sharpen orientation-tuning and strengthen response fidelity to naturalistic scenes. These findings establish a causal link between RA-induced retinal hyperactivity and vision impairment and define molecular targets and candidate drugs for boosting image-forming vision in retinal degeneration.


1965 ◽  
Vol 5 ◽  
pp. 120-130
Author(s):  
T. S. Galkina

It is necessary to have quantitative estimates of the intensity of lines (both absorption and emission) to obtain the physical parameters of the atmosphere of components.Some years ago at the Crimean observatory we began the spectroscopic investigation of close binary systems of the early spectral type with components WR, Of, O, B to try and obtain more quantitative information from the study of the spectra of the components.


2019 ◽  
Vol 1 (1) ◽  
pp. 15-21
Author(s):  
Rada Puspita ◽  
Haves Ashan ◽  
Fidiariani Sjaaf

Vision impairment is estimated to affect 285 million people in the world, where 16-20% experience blindness, from the number of blindness suffered at the age of 40-50 years. Cataract seninis is all lens opacities that are found in old age that is above 40 years. The purpose of identifying and collecting frequency data Profile of Senilis cataract patients at the age of 40 years and above at RSI Siti Rahmah Padang in 2017. The research method is descriptive type of research, this study data taken is secondary data, In this study data was taken from the Medical Record at RSI Siti Rahmah Padang. When the study was conducted in February-August 2018, the population of this study were all cataract patients at the age of 40 years and above at RSI Siti Rahmah Padang in 2017 with 80 samples. Data analysis is univariate presented in the form of a frequency distribution table. Results From 80 respondents as many as 40 people (50%) were in the age range of 60-69 years, as many as 42 people (52.5%) patients were male, as many as 31 people (38.8%) patients with high school education and 35 people (43.8%) patients work as private companies. Conclusion In general, most patients are at the age of 60-69 years, the most sex is men, the highest education is high school and most patients are private.


Sign in / Sign up

Export Citation Format

Share Document