Pharmacological effects of Lavandula officinalis Chaix and its polyphenols: Focus on their in vivo estrogenic and anti-inflammatory properties

2020 ◽

Vol 2020 ◽

pp. 1-21

Author(s):

Márcia Fernanda Correia Jardim Paz ◽

Marcus Vinícius Oliveira Barros de Alencar ◽

Rodrigo Maciel Paulino de Lima ◽

André Luiz Pinho Sobral ◽

Glauto Tuquarre Melo do Nascimento ◽

...

Keyword(s):

Genomic Instability ◽

Neutrophil Infiltration ◽

Protective Effects ◽

Pharmacological Effects ◽

Self Medication ◽

Study Objective ◽

Anti Inflammatory

Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six in vitro, and 76 in vivo studies. While controversial, the findings suggest that long-term use of OME (5 to 40 mg/kg) can induce genomic instability. On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction. The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices.

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An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666200313120419 ◽

2020 ◽

Vol 20 (11) ◽

pp. 988-1000 ◽

Cited By ~ 1

Author(s):

Bellamkonda Bosebabu ◽

Sri Pragnya Cheruku ◽

Mallikarjuna Rao Chamallamudi ◽

Madhavan Nampoothiri ◽

Rekha R. Shenoy ◽

...

Keyword(s):

Molecular Mechanisms ◽

Biological Effects ◽

Hepatoprotective Activity ◽

In Vivo Studies ◽

Therapeutic Effects ◽

Pharmacological Effects ◽

Bioactive Constituents ◽

Anti Inflammatory

Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non‐toxic chemical that mediates anti‐inflammatory effects by down‐regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.

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Pharmacological effects of Sesbania sesban: a systematic review

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200803 ◽

2020 ◽

Vol 8 (3) ◽

pp. 1185

Author(s):

Michael Nyongesa Walekhwa ◽

Teresa Kerubo Ogeto ◽

Mary Kanyiri Murithi ◽

Zablon Lister Malago

Keyword(s):

Dose Effect ◽

Phytochemical Analysis ◽

Sesbania Sesban ◽

Pharmacological Effects ◽

Industrialized Countries ◽

Middle Income ◽

Global Citizens ◽

Anti Inflammatory

The cost, side effects and imitation associated with conventional drugs have driven a substantial number of global citizens to resort to complementary medicine. Although largely informal and unregulated, the practice of herbal medicine is more engrained in low and middle income than in industrialized countries. Sesbania sesban, a plant which grows generously across most parts of the world, has been a major target by most traditional health practitioners. The effects so far reported include antimicrobial, anti-fertility, anti-diabetic, anti-inflammatory among others. No study has reviewed the scholarly works published and jointly reported results. Authros systematically reviewed papers available in different databases to give a hybrid report on the pharmacological effects of Sesbania sesban. A total of three data bases were searched using key terms like: Sesbania sesban, ethno-botany, phytochemical analysis, pharmacological effects etc. A total of 860 papers were initially recovered and further subjected to abstract and title examination which filtered them down to 40 papers. The 40 papers were assessed more against a set of criteria like: in-vivo and in-vitro studies biased to pharmacological effects of the plant, studies that were less than 15 years old and studies that used experimental design. This further scrutiny reduced the number of papers to 25. Most studies reported Sesbania sesban as having great anti-microbial, anti-fungal, anti-inflammatory and anti-diabetic qualities. No study reported any adverse effect of the plant. Authors recommend a dose-effect assessment and mechanism of action of the plant extracts especially with regard to the antimicrobial, anti-inflammatory and anti-fertility qualities.

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