Prevalence, antimicrobial resistance profile, and characterization of multi-drug resistant bacteria from various infected wounds in North Egypt

AbstractPathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O2− and HClO with its Fe2N6O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H2O2 (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies.

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Selection and dissemination of antimicrobial resistance in Agri-food production

Antimicrobial Resistance and Infection Control ◽

10.1186/s13756-019-0623-2 ◽

2019 ◽

Vol 8 (1) ◽

Cited By ~ 13

Author(s):

Guyue Cheng ◽

Jianan Ning ◽

Saeed Ahmed ◽

Junhong Huang ◽

Rizwan Ullah ◽

...

Keyword(s):

Heavy Metals ◽

Antimicrobial Resistance ◽

Food Production ◽

Food Industry ◽

Antimicrobial Agents ◽

Food Sources ◽

Resistant Bacteria ◽

Drug Resistant ◽

Food And Agriculture ◽

Drug Resistant Bacteria

Abstract Public unrest about the use of antimicrobial agents in farming practice is the leading cause of increasing and the emergences of Multi-drug Resistant Bacteria that have placed pressure on the agri-food industry to act. The usage of antimicrobials in food and agriculture have direct or indirect effects on the development of Antimicrobial resistance (AMR) by bacteria associated with animals and plants which may enter the food chain through consumption of meat, fish, vegetables or some other food sources. In addition to antimicrobials, recent reports have shown that AMR is associated with tolerance to heavy metals existing naturally or used in agri-food production. Besides, biocides including disinfectants, antiseptics and preservatives which are widely used in farms and slaughter houses may also contribute in the development of AMR. Though the direct transmission of AMR from food-animals and related environment to human is still vague and debatable, the risk should not be neglected. Therefore, combined global efforts are necessary for the proper use of antimicrobials, heavy metals and biocides in agri-food production to control the development of AMR. These collective measures will preserve the effectiveness of existing antimicrobials for future generations.

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Peritoneal Dialysis–Related Peritonitis from Carbapenemase-Producing Klebsiella pneumoniae with OXA-48 Type Gene

Peritoneal Dialysis International ◽

10.3747/pdi.2018.00234 ◽

2019 ◽

Vol 39 (1) ◽

pp. 97-98 ◽

Cited By ~ 3

Author(s):

Davin Ryanputra ◽

Dingding Wang ◽

Martin B. Lee ◽

Boon Wee Teo ◽

Pei Loo Tok

Keyword(s):

Peritoneal Dialysis ◽

Antimicrobial Resistance ◽

Klebsiella Pneumoniae ◽

Rare Case ◽

Resistant Bacteria ◽

Drug Resistant ◽

Automated Peritoneal Dialysis ◽

Drug Resistant Bacteria ◽

Type Gene

We report a rare case of carbapenemase-producing enterobacte-riaceae peritonitis in a patient undergoing automated peritoneal dialysis (APD). The PD catheter had to be removed as the patient remained unwell despite antibiotics. Antimicrobial resistance in PD peritonitis is a concern in this era of multi-drug resistant bacteria.

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Occurrence, Antimicrobial Resistance Profile, and Characterization of Extended-spectrum β-Lactamase–Producing Escherichia coli Isolates from Minced Meat at Local Markets in Thailand

Foodborne Pathogens and Disease ◽

10.1089/fpd.2021.0059 ◽

2021 ◽

Author(s):

Phoomjai Sornsenee ◽

Siriphorn Chimplee ◽

Arseesa Arbubaker ◽

Sutharinee Kongchai ◽

Hilmee Madimong ◽

...

Keyword(s):

Escherichia Coli ◽

Antimicrobial Resistance ◽

Local Markets ◽

Resistance Profile ◽

Extended Spectrum ◽

Antimicrobial Resistance Profile ◽

Minced Meat

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ThIV–Desferrioxamine: Characterization of a Fluorescent Bacterial Probe

Dalton Transactions ◽

10.1039/d1dt02177j ◽

2021 ◽

Author(s):

Kelly Alrich ◽

Maksim Livshits ◽

Loreen Stromberg ◽

Michael T. Janicke ◽

Mila Nhu Lam ◽

...

Keyword(s):

Global Health ◽

Resistant Bacteria ◽

Drug Resistant ◽

Drug Resistant Bacteria

Diversifying our ability to guard against emerging pathogenic threats is essential for keeping pace with global health challenges, including those presented by drug-resistant bacteria. Some modern diagnostic and therapeutic innovations...

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Molecular Characterization of Resistance-Nodulation-Division Transporters from Solvent- and Drug-Resistant Bacteria in Petroleum-Contaminated Soil

Applied and Environmental Microbiology ◽

10.1128/aem.71.1.580-586.2005 ◽

2005 ◽

Vol 71 (1) ◽

pp. 580-586 ◽

Cited By ~ 22

Author(s):

Norika Meguro ◽

Yumiko Kodama ◽

Maria-Trinidad Gallegos ◽

Kazuya Watanabe

Keyword(s):

Contaminated Soil ◽

Contaminated Soils ◽

Resistant Bacteria ◽

Drug Resistant ◽

Transporter Gene ◽

Competitive Pcr ◽

Drug Resistant Bacteria ◽

Resistance Nodulation Division ◽

Petroleum Contaminated Soil

ABSTRACT PCR assays for analyzing resistance-nodulation-division transporters from solvent- and drug-resistant bacteria in soil were developed. Sequence analysis of amplicons showed that the PCR successfully retrieved transporter gene fragments from soil. Most of the genes retrieved from petroleum-contaminated soils formed a cluster (cluster PCS) that was distantly related to known transporter genes. Competitive PCR showed that the abundance of PCS genes is increased in petroleum-contaminated soil.

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Molecular characterization of virulence and antimicrobial resistance profile of Shigella species isolated from children with moderate to severe diarrhea in northeastern Brazil

Diagnostic Microbiology and Infectious Disease ◽

10.1016/j.diagmicrobio.2017.11.002 ◽

2018 ◽

Vol 90 (3) ◽

pp. 198-205 ◽

Cited By ~ 8

Author(s):

Pedro Henrique Quintela Soares Medeiros ◽

Aldo Ângelo Moreira Lima ◽

Marjorie Moreira Guedes ◽

Alexandre Havt ◽

Mariana Duarte Bona ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Molecular Characterization ◽

Northeastern Brazil ◽

Resistance Profile ◽

Severe Diarrhea ◽

Shigella Species ◽

Antimicrobial Resistance Profile

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The Carbapenems Issue

The Southwest Respiratory and Critical Care Chronicles ◽

10.12746/swrccc.v6i25.476 ◽

2018 ◽

Vol 6 (25) ◽

pp. 5-7

Author(s):

David Sotello ◽

Wadih Chakkour ◽

Kristen Fuhrmann

Keyword(s):

Antimicrobial Resistance ◽

Early Recognition ◽

Carbapenem Resistance ◽

Resistant Bacteria ◽

Drug Resistant ◽

Drug Resistant Bacteria ◽

Important Concern ◽

Risk Patients ◽

Poor Outcomes ◽

Rational Use Of Antibiotics

The development of antibiotics remains one of the great advances in medicine. Antibiotics have saved countless lives. Unfortunately, the widespread use of antimicrobials has led to the development of antimicrobial resistance. Antibiotic resistance is an important concern for public health; it is associated with poor outcomes. Carbapenems, members of the β-lactam class of antibiotics, have the broadest spectrum of antimicrobial activity. Carbapenem resistance is one of the toughest challenges in infectious diseases; it is associated with high mortality and is seen more often now due to the proliferation of multi-drug resistant bacteria. Multiple genes that cause carbapenem resistance have been identified. Resistance transmission is usually nosocomial, but community-acquired infections with resistance have been reported. Early recognition of high risk patients for multi-drug resistant infections is fundamental for adequate management. The rational use of antibiotics is required to prevent the spread of antimicrobial resistance; this requires multidisciplinary efforts among clinicians, Infection Control departments, and Antimicrobial Stewardship programs.

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The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

Research ◽

10.34133/2020/2016201 ◽

2020 ◽

Vol 2020 ◽

pp. 1-32

Author(s):

Zifang Shang ◽

Siew Yin Chan ◽

Qing Song ◽

Peng Li ◽

Wei Huang

Keyword(s):

Antimicrobial Resistance ◽

Drug Efficacy ◽

Resistant Bacteria ◽

Drug Resistant ◽

Global Public Health ◽

Antimicrobial Drugs ◽

Drug Resistant Bacteria ◽

New Antibiotics ◽

Conventional Antibiotics ◽

Therapeutic Monoclonal Antibodies

The emerging antimicrobial resistance (AMR) poses serious threats to the global public health. Conventional antibiotics have been eclipsed in combating with drug-resistant bacteria. Moreover, the developing and deploying of novel antimicrobial drugs have trudged, as few new antibiotics are being developed over time and even fewer of them can hit the market. Alternative therapeutic strategies to resolve the AMR crisis are urgently required. Pathogen-oriented therapy (POT) springs up as a promising approach in circumventing antibiotic resistance. The tactic underling POT is applying antibacterial compounds or materials directly to infected regions to treat specific bacteria species or strains with goals of improving the drug efficacy and reducing nontargeting and the development of drug resistance. This review exemplifies recent trends in the development of POTs for circumventing AMR, including the adoption of antibiotic-antibiotic conjugates, antimicrobial peptides, therapeutic monoclonal antibodies, nanotechnologies, CRISPR-Cas systems, and microbiota modulations. Employing these alternative approaches alone or in combination shows promising advantages for addressing the growing clinical embarrassment of antibiotics in fighting drug-resistant bacteria.

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