Endothelial progenitor cells in cardiovascular disease and hypoxia—potential implications to obstructive sleep apnea

2011 ◽  
Vol 158 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Slava Berger ◽  
Lena Lavie
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Obstructive Sleep

scholarly journals Altered profile of circulating endothelial progenitor cells in obstructive sleep apnea

2012 ◽  
Vol 17 (3) ◽  
pp. 937-942 ◽  
Author(s):  
Macy Mei-Sze Lui ◽  
Hung-Fat Tse ◽  
Judith Choi-Wo Mak ◽  
Jamie Chung-Mei Lam ◽  
David Chi-Leung Lam ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Obstructive Sleep

scholarly journals The Association of Nephroblastoma Overexpressed (NOV) and Endothelial Progenitor Cells with Oxidative Stress in Obstructive Sleep Apnea

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Eddie W. Fakhouri ◽  
Jeremy A. Weingarten ◽  
Shailendra P. Singh ◽  
Purvi Shah ◽  
Stephen J. Peterson
Keyword(s):  
Oxidative Stress ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Subsequent Development ◽  
Circulating Endothelial Cells ◽  
Endothelial Progenitor ◽  
Obstructive Sleep ◽  
Age And Sex

Objective. Obstructive sleep apnea (OSA) is a sleep disorder characterized by intermittent hypoxia, chronic inflammation, and oxidative stress and is associated with cardiometabolic disease. Several biological substrates have been associated with OSA such as nephroblastoma overexpressed (NOV), endothelial progenitor cells (EPC), and circulating endothelial cells (CEC). Few studies have looked at the association of NOV with OSA while the EPC/CEC relationships with OSA are unclear. In this study, we hypothesize that (1) NOV is associated with the severity of OSA independent of BMI, identifying a protein that may play a role in the biogenesis of OSA complications, and (2) EPCs and CECs are also associated with the severity of OSA and are biomarkers of endothelial dysfunction in OSA. Methods. 61 subjects underwent overnight polysomnography (PSG), clinical evaluation, and blood analysis for NOV, EPC, CEC, interleukin 6 (IL-6), and other potential biomarkers. Results. NOV and EPCs were independently associated with the oxygen desaturation index (ODI) after adjusting for potential confounders including body mass index (BMI), age, and sex (NOV p = 0.032 ; EPC p = 0.001 ). EPC was also independently associated with AHI after adjusting for BMI, age, and sex ( p = 0.017 ). IL-6 was independently associated with AHI, but not with ODI. Conclusion. NOV and EPC levels correlate with the degree of OSA independent of BMI, indicating that these biomarkers could potentially further elucidate the relationship between OSA patients and their risk of the subsequent development of cardiovascular disease.

scholarly journals Circulating Endothelial Cells and Endothelial Progenitor Cells in Obstructive Sleep Apnea

Lung ◽  
2008 ◽  
Vol 186 (3) ◽  
pp. 145-150 ◽  
Author(s):  
Kevin Martin ◽  
Michael Stanchina ◽  
Nicola Kouttab ◽  
Elizabeth O. Harrington ◽  
Sharon Rounds
Keyword(s):  
Endothelial Cells ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Circulating Endothelial Cells ◽  
Endothelial Progenitor ◽  
Obstructive Sleep
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