Pilot Study of Prostate Cancer Angiogenesis Imaging Using a Photoacoustic Imaging System

Urology ◽  
2017 ◽  
Vol 108 ◽  
pp. 212-219 ◽  
Author(s):  
Akio Horiguchi ◽  
Masayuki Shinchi ◽  
Akiko Nakamura ◽  
Takatsugu Wada ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Imaging System ◽  
Photoacoustic Imaging

A pilot study of photoacoustic imaging system for improved real-time visualization of neurovascular bundle during radical prostatectomy

The Prostate ◽  
2015 ◽  
Vol 76 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Akio Horiguchi ◽  
Kazuhiro Tsujita ◽  
Kaku Irisawa ◽  
Tadashi Kasamatsu ◽  
Kazuhiro Hirota ◽  
...  
Keyword(s):  
Pilot Study ◽  
Radical Prostatectomy ◽  
Real Time ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Neurovascular Bundle ◽  
Real Time Visualization

scholarly journals Targeted Imaging of Orthotopic Prostate Cancer by Using Clinical Transformable Photoacoustic Molecular Probe

2020 ◽  
Author(s):  
Chen Qiu ◽  
Yuanyuan Bai ◽  
Tinghui Yin ◽  
Xiaoyan Miao ◽  
Rongkang Gao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Current Trend ◽  
Molecular Probe ◽  
High Yield ◽  
Control Group ◽  
Targeted Imaging ◽  
Normal Prostate

Abstract Background: To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using a real-time molecular photoacoustic imaging system integrated with a handheld US probe (PAI/US) and synthesized an integrin α v β 3 targeted probe based on ICG (cRGD–ICG). Results: A small molecular PAI probe was synthesized and exhibited excellent targeted imaging ability in vitro . In vivo photoacoustic imaging was carried out after intravenous injection of cRGD-ICG in orthotopic PCa-bearing rats under the facilitation of the PAI/US system. Maximum molecular photoacoustic signals were observed in the tumor area in vivo after the probe injection, which showed 3.8-fold higher signal enhancement than that in the control group ( P < 0.05). Significantly higher cRGD-ICG accumulation was observed under confocal microscopy in the tumor region than in normal prostate tissue. Conclusions: All our results showed that the comprehensive strategy provided a high-yield and reliable method for PCa diagnosis and targeted prostate biopsy, with great clinical translation potential.

scholarly journals Targeted Imaging of Orthotopic Prostate Cancer by Using Clinical Transformable Photoacoustic Molecular Probe

2019 ◽  
Author(s):  
Chen Qiu ◽  
Tinghui Yin ◽  
Yuanyuan Bai ◽  
Xiaoyan Miao ◽  
Rongkang Gao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Current Trend ◽  
Molecular Probe ◽  
High Yield ◽  
Control Group ◽  
Targeted Imaging ◽  
Normal Prostate

Abstract Background: To obtain high yield histological samples by targeted PCa biopsy is the current trend compared of transrectal ultrasound (TRUS) guided systematic histological biopsy which is regarded as golden standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using real-time molecular photoacoustic imaging system integrated with handheld US probe (PAI/US) and synthesized integrin αvβ3 targeted probe based on ICG (cRGD–ICG). Results: A small molecular PAI probe was synthesized and proved excellent targeted imaging ability in vitro. In vivo photoacoustic imaging was carried out after intravenous injection of cRGD-ICG in orthotopic PCa bearing beard rats under facilitation of PAI/US system. Maximum molecular photoacoustic signals were observed in the tumor area in vivo post probe injection, which showed 3.8 folds higher signal enhancement than in the control group (P < 0.05, respectively). Significant higher cRGD-ICG accumulation was observed under confocal microscopy in tumor region rather than normal prostate tissue. Conclusions: All our results showed that the comprehensive strategy provided a high-yield and reliable method for PCa diagnosis and targeted prostate biopsy, with great clinical transforming potential.

scholarly journals High spectral and spatial resolution MRI of prostate cancer: a pilot study

2021 ◽  
Author(s):  
Milica Medved ◽  
Aritrick Chatterjee ◽  
Ajit Devaraj ◽  
Carla Harmath ◽  
Grace Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Spatial Resolution
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