Trend of global quality of life in localized or metastatic prostate cancer patients after treatment

PURPOSE: A combination of mitoxantrone plus prednisone is preferable to prednisone alone for reduction of pain in men with metastatic, hormone-resistant, prostate cancer. The purpose of this study was to assess the effects of these treatments on health-related quality of life (HQL). PATIENTS AND METHODS: Men with metastatic prostate cancer (n = 161) were randomized to receive either daily prednisone alone or mitoxantrone (every 3 weeks) plus prednisone. Those who received prednisone alone could have mitoxantrone added after 6 weeks if there was no improvement in pain. HQL was assessed before treatment initiation and then every 3 weeks using the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30 (EORTC QLQ-C30) and the Quality of Life Module–Prostate 14 (QOLM-P14), a trial-specific module developed for this study. An intent-to-treat analysis was used to determine the mean duration of HQL improvement and differences in improvement duration between groups of patients. RESULTS: At 6 weeks, both groups showed improvement in several HQL domains, and only physicalfunctioning and pain were better in the mitoxantrone-plus-prednisone group than in the prednisone-alone group. After 6 weeks, patients taking prednisone showed no improvement in HQL scores, whereas those taking mitoxantrone plus prednisone showed significant improvements in global quality of life (P = .009), four functioning domains, and nine symptoms (.001 < P < .01), and the improvement (> 10 units on a scale of 0 to100) lasted longer than in the prednisone-alone group (.004 < P < .05). The addition of mitoxantrone to prednisone after failure of prednisone alone was associated with improvements in pain, pain impact, pain relief, insomnia, and global quality of life (.001 < P < .003). CONCLUSION: Treatment with mitoxantrone plus prednisone was associated with greater and longer-lasting improvement in several HQL domains and symptoms than treatment with prednisone alone.

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65 Effect of prostate specific antigen parameters on global quality of life in prostate cancer patients during follow-up

European Urology Supplements ◽

10.1016/s1569-9056(16)60067-2 ◽

2016 ◽

Vol 15 (3) ◽

pp. e65

Author(s):

Y-L. Kao ◽

Y-S. Tsai ◽

F-Y. Ou ◽

Z-Y. Lin ◽

C-H. Ou ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Patients ◽

Prostate Specific Antigen ◽

Specific Antigen ◽

Global Quality ◽

Global Quality Of Life

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A cognitive–existential intervention to improve existential and global quality of life in cancer patients: A pilot study

Palliative & Supportive Care ◽

10.1017/s147895151400073x ◽

2014 ◽

Vol 13 (4) ◽

pp. 981-990 ◽

Cited By ~ 10

Author(s):

Pierre Gagnon ◽

Lise Fillion ◽

Marie-Anik Robitaille ◽

Michèle Girard ◽

François Tardif ◽

...

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Usual Care ◽

Cancer Patients ◽

Group Intervention ◽

Usual Condition ◽

Global Quality ◽

Global Quality Of Life ◽

The Individual

AbstractObjective:We developed a specific cognitive–existential intervention to improve existential distress in nonmetastatic cancer patients. The present study reports the feasibility of implementing and evaluating this intervention, which involved 12 weekly sessions in both individual and group formats, and explores the efficacy of the intervention on existential and global quality of life (QoL) measures.Method:Some 33 nonmetastatic cancer patients were randomized between the group intervention, the individual intervention, and the usual condition of care. Evaluation of the intervention on the existential and global QoL of patients was performed using the existential well-being subscale and the global scale of the McGill Quality of Life (MQoL) Questionnaire.Results:All participants agreed that their participation in the program helped them deal with their illness and their personal life. Some 88.9% of participants agreed that this program should be proposed for all cancer patients, and 94.5% agreed that this intervention helped them to reflect on the meaning of their life. At post-intervention, both existential and psychological QoL improved in the group intervention versus usual care (p = 0.086 and 0.077, respectively). At the three-month follow-up, global and psychological QoL improved in the individual intervention versus usual care (p = 0.056 and 0.047, respectively).Significance of results:This pilot study confirms the relevance of the intervention and the feasibility of the recruitment and randomization processes. The data strongly suggest a potential efficacy of the intervention for existential and global quality of life, which will have to be confirmed in a larger study.

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Identification of determinants influencing quality of life in metastatic prostate cancer patients

European Urology Open Science ◽

10.1016/s2666-1683(21)03152-9 ◽

2021 ◽

Vol 33 ◽

pp. S304-S305

Author(s):

G. Tlili ◽

E.M. Acacha ◽

K. Ben Ahmed ◽

S. Dziri ◽

A. Azzebi ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Patients ◽

Metastatic Prostate Cancer

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FACTORS AFFECTING QUALITY OF LIFE AND LEVEL OF SOCIAL SUPPORT IN CANCER PATIENTS

Belitung Nursing Journal ◽

10.33546/bnj.48 ◽

2017 ◽

Vol 3 (2) ◽

pp. 54-64 ◽

Cited By ~ 2

Author(s):

Ayse Berivan BAKAN ◽

Asuman GURAKSIN

Keyword(s):

Quality Of Life ◽

Social Support ◽

Cancer Patients ◽

Social Relations ◽

Perceived Social Support ◽

Well Being ◽

Global Quality ◽

Quality Of Life Scale ◽

Global Quality Of Life

Background: When people face health problems, their life satisfaction levels and social relations could be ruined. When it comes to an eerie, deadly and chronic disease like cancer, the individual is much more likely to be affected by it.Objective: This descriptive study aims to identify quality of life and level of social support and the affecting factors in cancer patients.Methods: The sample included 170 patients who applied to Internal Diseases, Radiation Oncology, Thorax diseases clinics and Chemotherapy polyclinic in a university hospital in Turkey between March and August, 2005, who met the research criteria, and who volunteered to participate in the study. The sample represented 20 % of the target population. Data were collected through SF-36 Quality of Life Scale and Multidimensional Scale of Perceived Social Support.Results: The patients’ Global Quality of Life mean score was found 38.67 ± 13.64, and mean score for the Perceived Social Support was found 59.19 ± 17.5. Global Quality of Life score was higher in those who underwent an operation and who received ambulatory health care. Although Global Quality of Life was not influenced by the gender variable, male patients’ level of well-being was found to be higher. Perceived Social Support total score was found to be higher in those who knew about their disease. Family support was found to be higher in those who were married and who lived in town; it was found to be low in those who had low socio-economic level and who received inpatient treatment. Friend support was found to be high in those who knew about their disease.Conclusion: There was a linear relationship between Perceived Social Support and Quality of Life. It is recommended that more studies with wider groups of participants would shed more light to the issue of identifying quality of life, social support level and the relationships between them in cancer patients.

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