scholarly journals Applications of Machine Learning in Solid Oral Dosage Form Development

Author(s):  
Hao Lou ◽  
Bo Lian ◽  
Michael J Hageman
INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (05) ◽  
pp. 14-23
Author(s):  
D. M. More ◽  
◽  
P. D. Chaudhari ◽  
S. D. More

Present work was aimed to develop a platform technology for pediatric dosage form which masks the bitter taste of a drug and to prepare flexible solid oral dosage form using hot melt extrusion (HME). Eudragit EPO, a cationic co-polymer insoluble in pH above 5, was used as a taste masking polymer to restrict the drug release in saliva. Soluplus, a graft co-polymer freely soluble in water was used as solubility enhancer. Test formulation released less than 10 % drug Tenofovir Disoproxil Fumarate (TDF) in pH 6.8 compared to 89% of marketed formulation simulated to limited release of drug in the saliva and thus avoiding the bitterness. DSC and XRD tests confirmed the existence of molecularly dispersed drug. FTIR confirmed the presence of unchanged functional groups of drug in its tablet form after HME processing. Proposed platform technology successfully masked the bitter taste in the ratio of D:P 1:2 and overcame this challenge of oral dosage form.


2017 ◽  
Vol 106 (5) ◽  
pp. 1218-1238 ◽  
Author(s):  
Cherokee S. Hoaglund Hyzer ◽  
Michele L. Williamson ◽  
Patrick J. Jansen ◽  
Michael E. Kopach ◽  
R. Brian Scherer ◽  
...  

2017 ◽  
Vol 100 (5) ◽  
pp. 1304-1307 ◽  
Author(s):  
Carolyn Q Burdette

Abstract Vitamin D is an important nutrient for many areas of human health and well-being, including improved bone strength, muscle movement, cognitive function, and immune health. The National Institute of Standards and Technology, in collaboration with the National Institutes of Health Office of Dietary Supplements, has developed SRM 3532 Calcium-Containing Solid Oral Dosage Form to help address the analytical challenges seen by the dietary supplement communities for the determination of vitamin D3 (cholecalciferol) and elements. Described here is the process to assess the homogeneity and stability of the material, as well as the value assignment of the vitamin D3 levels.


2015 ◽  
Vol 496 (2) ◽  
pp. 299-303 ◽  
Author(s):  
John D. Smart ◽  
Sian Dunkley ◽  
John Tsibouklis ◽  
Simon Young

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