Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway

2022 ◽  
pp. 113025
Author(s):  
Fen Xu ◽  
Jiamin Zhang ◽  
Xiaoyan Zhou ◽  
Hua Hao
2016 ◽  
Vol 591 ◽  
pp. 57-65 ◽  
Author(s):  
Stephen L. Slocum ◽  
John J. Skoko ◽  
Nobunao Wakabayashi ◽  
Susan Aja ◽  
Masayuki Yamamoto ◽  
...  

2017 ◽  
Vol 799 ◽  
pp. 201-210 ◽  
Author(s):  
Zheng Wang ◽  
Sun-O Ka ◽  
Youngyi Lee ◽  
Byung-Hyun Park ◽  
Eun Ju Bae
Keyword(s):  
P38 Mapk ◽  
High Fat ◽  

2021 ◽  
Author(s):  
Jie Cheng ◽  
Meng Zhang ◽  
Shaoli Cheng ◽  
Fan Li ◽  
Bingyi Zhang ◽  
...  

Low-dose alcohol protected HFD-induced obese mice from the augmentation of anxiety-related behavior, which might be related to APN upregulation and Nrf2 activation.


2017 ◽  
Vol 82 (8) ◽  
pp. 1953-1960 ◽  
Author(s):  
Bin Wang ◽  
Jin Sun ◽  
Yonghui Shi ◽  
Guowei Le

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3027 ◽  
Author(s):  
Xuan Cai ◽  
Fan Yang ◽  
Lihui Zhu ◽  
Ye Xia ◽  
Qingyuan Wu ◽  
...  

Many studies have shown that Orthosiphon stamineus extract (OE) has antioxidant activity, and we previously reported that OE protects the intestine against injury from a high-fat diet. However, the molecular mechanism underlying this protective effect of OE was unclear. Here, OE was separated according to polarity and molecular weight, and the antioxidant activity of each component was compared. The components with the highest antioxidant activity were analyzed by HPLC, which confirmed that rosmarinic acid (RA) was the main effective constituent in OE. OE and RA were then tested in a mouse high-fat diet-induced intestinal injury model. The antioxidant indices and morphological characteristics of the mouse jejunum were measured, and activation of the nuclear factor E2-related factor 2 (Nrf2) pathway and apoptosis of jejunal epithelial cells were analyzed. Of all the constituents in OE, RA contributed the most. Both RA and OE activated the Nrf2 pathway and increased downstream antioxidant enzyme activity. RA and OE protected the mouse intestine against high-fat diet-induced oxidative stress by preventing intestinal epithelial cell apoptosis via both extracellular and intracellular pathways. Thus, RA, the main effective constituent in OE, inhibits intestinal epithelial apoptosis by regulating the Nrf2 pathway in mice.


2018 ◽  
Vol 315 (2) ◽  
pp. E180-E195 ◽  
Author(s):  
Dionysios V. Chartoumpekis ◽  
Dushani L. Palliyaguru ◽  
Nobunao Wakabayashi ◽  
Marco Fazzari ◽  
Nicholas K. H. Khoo ◽  
...  

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a canonical regulator of cytoprotective gene expression, but evidence of its cross talk with other pathways, including metabolic ones, is ever increasing. Pharmacologic or systemic genetic activation of the Nrf2 pathway partially protects from obesity in mice and ameliorates fasting hyperglycemia in mice and humans. However, systemic Nrf2 deletion also protects from diet-induced obesity and insulin resistance in mice. To further investigate the effect of the disruption of Nrf2 on obesity in a tissue-specific manner, we focused on adipocytes and hepatocytes with targeted deletion of Nrf2. To this end, mice with cell-specific deletion of Nrf2 in adipocytes (ANKO) or hepatocytes (HeNKO) were fed a high-fat diet (HFD) for 6 mo and showed similar increases in body weight and body fat content. ANKO mice showed a partially deteriorated glucose tolerance, higher fasting glucose levels, and higher levels of cholesterol and nonesterified fatty acids compared with their Control counterparts. The HeNKO mice, though, had lower insulin levels and trended toward improved insulin sensitivity without having any difference in liver triglyceride accumulation. This study compared for the first time two conditional Nrf2 knockout models in adipocytes and in hepatocytes during HFD-induced obesity. None of these models could completely recapitulate the unexpected protection against obesity observed in the whole body Nrf2 knockout mice, but this study points out the differential roles that Nrf2 may play, beyond cytoprotection, in different target tissues and rather suggests systemic activation of the Nrf2 pathway as an effective means of prevention and treatment of obesity and type 2 diabetes.


Life Sciences ◽  
2018 ◽  
Vol 193 ◽  
pp. 159-170 ◽  
Author(s):  
Nada F. Abo El-Magd ◽  
Mohamed El-Mesery ◽  
Amro El-Karef ◽  
Mamdouh M. El-Shishtawy

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