This paper demonstrates how to calculate Craig-Bampton component mode synthesis matrices from measured frequency response functions. The procedure is based on a modified residual flexibility method, from which the Craig-Bampton CMS matrices are recovered, as presented in the companion paper, Part I (Morgan et al., 1998). A system of two coupled beams is analyzed using the experimentally-based method. The individual beams’ CMS matrices are calculated from measured frequency response functions. Then, the two beams are analytically coupled together using the test-derived matrices. Good agreement is obtained between the coupled system and the measured results.