The rapid anti-suicidal ideation effect of ketamine: A systematic review

Abstract Background Given the widespread nature and clinical consequences of self-harm and suicidal ideation among adolescents, establishing the efficacy of developmentally appropriate treatments that reduce both self-harm and suicidal ideation in the context of broader adolescent psychopathology is critical. Methods We conducted a systematic review and meta-analysis of the Dialectical Behaviour Therapy for Adolescents (DBT-A) literature on treating self-injury in adolescents (12–19 years). We searched for eligible trials and treatment evaluations published prior to July 2020 in MEDLINE/PubMed, Scopus, Google Scholar, EMBASE, and the Cochrane Library databases for clinical trials. Twenty-one studies were identified [five randomized-controlled trials (RCTs), three controlled clinical trials (CCTs), and 13 pre-post evaluations]. We extracted data for predefined primary (self-harm, suicidal ideation) and secondary outcomes (borderline personality symptoms; BPD) and calculated treatment effects for RCTs/CCTs and pre-post evaluations. This meta-analysis was pre-registered with OSF: osf.io/v83e7. Results Overall, the studies comprised 1673 adolescents. Compared to control groups, DBT-A showed small to moderate effects for reducing self-harm (g = −0.44; 95% CI −0.81 to −0.07) and suicidal ideation (g = −0.31, 95% CI −0.52 to −0.09). Pre-post evaluations suggested large effects for all outcomes (self-harm: g = −0.98, 95% CI −1.15 to −0.81; suicidal ideation: g = −1.16, 95% CI −1.51 to −0.80; BPD symptoms: g = −0.97, 95% CI −1.31 to −0.63). Conclusions DBT-A appears to be a valuable treatment in reducing both adolescent self-harm and suicidal ideation. However, evidence that DBT-A reduces BPD symptoms was only found in pre-post evaluations.

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Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a systematic review and meta-analysis

General Psychiatry ◽

10.1136/gpsych-2020-100247 ◽

2021 ◽

Vol 34 (2) ◽

pp. e100247

Author(s):

Matt Pelton ◽

Matt Ciarletta ◽

Holly Wisnousky ◽

Nicholas Lazzara ◽

Monica Manglani ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Suicidal Ideation ◽

General Population ◽

Suicide Attempts ◽

Advanced Disease ◽

Meta Analysis ◽

People Living With Hiv ◽

Meta Regression ◽

Living With Hiv

BackgroundPeople living with HIV/AIDS (PLWHA) must contend with a significant burden of disease. However, current studies of this demographic have yielded wide variations in the incidence of suicidality (defined as suicidal ideation, suicide attempt and suicide deaths).AimsThis systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.MethodsPublications were identified from PubMed (MEDLINE), SCOPUS, OVID (MEDLINE), Joanna Briggs Institute EBP and Cochrane Library databases (from inception to before 1 February 2020). The search strategy included a combination of Medical Subject Headings associated with suicide and HIV. Researchers independently screened records, extracted outcome measures and assessed study quality. Data were pooled using a random-effects model. Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity. Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.ResultsA total of 185 199 PLWHA were identified from 40 studies (12 cohorts, 27 cross-sectional and 1 nested case-control). The overall incidence of suicide completion in PLWHA was 10.2/1000 persons (95%CI: 4.5 to 23.1), translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons. The lifetime prevalence of suicide attempts was 158.3/1000 persons (95%CI: 106.9 to 228.2) and of suicidal ideation was 228.3/1000 persons (95%CI: 150.8 to 330.1). Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease (AIDS), the risk of suicide completion increased by 34 per 1000 persons. The quality of evidence by Grading of Recommendations, Assessment, Development and Evaluations for the suicide deaths was graded as ‘moderate’ quality.ConclusionsThe risk of suicide death is 100-fold higher in people living with HIV than in the general population. Lifetime incidence of suicidal ideation and attempts are substantially high. Suicide risk assessments should be a priority in PLWHA, especially for those with more advanced disease.

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Prevalence of Suicidal Ideation, Suicide Attempt, and Suicide Plan Among HIV/AIDS: A Systematic Review and Meta-Analysis

Journal of Affective Disorders ◽

10.1016/j.jad.2021.05.064 ◽

2021 ◽

Author(s):

Ju-Hong Pei ◽

Yi-xuan Pei ◽

Tong Ma ◽

Ye-hui Du ◽

Xing-Lei Wang ◽

...

Keyword(s):

Systematic Review ◽

Suicidal Ideation ◽

Suicide Attempt ◽

Meta Analysis ◽

Suicide Plan ◽

Hiv Aids

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A systematic review and evaluation of measures for suicidal ideation and behaviors in population-based research.

Psychological Assessment ◽

10.1037/pas0000053 ◽

2015 ◽

Vol 27 (2) ◽

pp. 501-512 ◽

Cited By ~ 91

Author(s):

Philip J. Batterham ◽

Maria Ftanou ◽

Jane Pirkis ◽

Jacqueline L. Brewer ◽

Andrew J. Mackinnon ◽

...

Keyword(s):

Systematic Review ◽

Suicidal Ideation ◽

Population Based ◽

And Behaviors

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Prevalence of suicidal behavior in young university students: A systematic review with meta-analysis

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.5320.3495 ◽

2021 ◽

Vol 29 ◽

Author(s):

Marília de Oliveira Crispim ◽

Cândida Maria Rodrigues dos Santos ◽

Iracema da Silva Frazão ◽

Cecília Maria Farias de Queiroz Frazão ◽

Rossana Carla Rameh de Albuquerque ◽

...

Keyword(s):

Systematic Review ◽

Suicidal Ideation ◽

University Students ◽

Suicidal Behavior ◽

Attempted Suicide ◽

Data Extraction ◽

Meta Analysis ◽

Cross Sectional ◽

High Prevalence ◽

Theses And Dissertations

Objective: to identify the prevalence of suicidal behavior in young university students. Method: a systematic review with meta-analysis of cross-sectional studies based on the Joanna Briggs Institute proposal, and carried out in the PubMed, Web of Science, Scopus, PsycINFO and LILACS databases and in the Brazilian Digital Library of Theses and Dissertations, with no language or year restrictions. A total of 2,942 publications were identified. Selection, data extraction and methodological evaluation of the studies were performed by two independent researchers. The meta-analysis was performed considering the random effects model. Results: eleven articles were included in this review. The prevalence variation for suicidal ideation was from 9.7% to 58.3% and, for attempted suicide, it was from 0.7% to 14.7%. The meta-analysis showed a 27.1% prevalence for suicidal ideation in life, 14.1% for ideation in the last year, and 3.1% for attempted suicide in life. Conclusion: the high prevalence of suicidal behavior, even with the considerable heterogeneity of the studies, raises the need to implement interventions aimed at preventing suicide and promoting mental health, especially in the academic environment.

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Preditores de idealização suicida entre estudantes de medicina: uma revisão sistemática

International Journal of Health Education ◽

10.17267/2594-7907ijhe.v3i1.2413 ◽

2019 ◽

Vol 3 (1) ◽

pp. 78

Author(s):

Victor Meireles Campos ◽

Ieda Aleluia

Keyword(s):

Systematic Review ◽

Medical Students ◽

Suicidal Ideation ◽

Suicide Attempts ◽

Training Methods ◽

Increased Risk ◽

The World ◽

The Subject ◽

Health Objective ◽

De Medicina

BACKGROUND: Suicidal ideation is one of the main symptoms indicative of suicide attempts and suicide. According to the WHO, about 800,000 cases of suicide were reported around the world in 2014, which translates to an index of 1 suicide every 40 seconds. Medical students constitute a population at risk for the development of suicidal ideation. Several life factors may influence the risk of suicidal ideation, those being personality traits, social factors and mental health. OBJECTIVE: Identify the indicators of suicidal ideation among medical students during their academic training. METHODS: This is a systematic review carried out in the electronic databases Pubmed and BVS. Articles that addressed the subject of suicidal ideation among medical students in Portuguese, English and Spanish from 2008 to 2018 were included. RESULTS: We found 263 articles, of which 12 articles met the inclusion and exclusion criteria. After the application of the STROBE statement, 6 articles were selected for the creation of this systematic review. The prevalence of suicidal ideation varied from 3.7% to 35.6% around the world and several factors were linked to the increase of suicidal ideation risk. CONCLUSION: A suicidal ideation is a frequent and multifactorial phenomenon that involves several realms of a medical student's life. The risk factors identified in this review were linked to the increased risk of suicidal ideation development.

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