Mediastinal Nonseminomatous Germ Cell Tumors: The Role of Combined Modality Therapy

1982 ◽  
Vol 33 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Nicholas J. Vogelzang ◽  
Derek Raghavan ◽  
Robert W. Anderson ◽  
Juan Rosai ◽  
Seymour H. Levitt ◽  
...  
Keyword(s):  
Germ Cell ◽  
Combined Modality Therapy ◽  
Germ Cell Tumors ◽  
Combined Modality ◽  
Nonseminomatous Germ Cell Tumors

Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors

Surgery Today ◽  
2013 ◽  
Vol 44 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Hideki Kuwano ◽  
Takehiro Tsuchiya ◽  
Tomonori Murayama ◽  
Atsushi Sano ◽  
Kazuhiro Nagayama ◽  
...  
Keyword(s):  
Germ Cell ◽  
Combined Modality Therapy ◽  
Germ Cell Tumors ◽  
Stage Iii ◽  
Combined Modality ◽  
Malignant Germ Cell Tumors

Acute Myeloblastic Leukemia Associated with Mediastinal Nonseminomatous Germ Cell Tumors. Report on two Cases

1995 ◽  
Vol 81 (4) ◽  
pp. 299-301 ◽  
Author(s):  
Alfredo Berruti ◽  
Enrica Pazè ◽  
Enrica Fara ◽  
Gabriella Gorzegno ◽  
Luigi Dogliotti
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Radical Resection ◽  
Hematologic Neoplasms ◽  
Poor Survival ◽  
Hematologic Disorder ◽  
Chemotherapy Administration ◽  
Nonseminomatous Germ Cell Tumors ◽  
Median Interval

The demonstrated association with hematologic neoplasms may partially account for the poor survival of patients with mediastinal nonseminomatous germ cell tumors (MNSGCT) compared to patients with testicular and retroperitoneal counterparts. It has been shown that the median interval from the diagnosis of MNSGCT to the diagnosis of the hematologic disorders is 6 months, which contrasts sharply with the average time of 2 to 3 years for the development of therapy-related leukemias. The 2 cases herein described, 1 male and 1 female, developed acute M2 leukemia 4 and 2 years after the diagnosis of MNSGCT. In the second patient (the first female ever described), we cannot exclude a pathogenetic role of the PEB regimen (platinum, etoposide, bleomicin), even though the total dose of etoposide administred has been demonstrated to have a mild leukemogenic potential. This is not the case of the first patient, who did not receive adjuvant chemotherapy after the radical resection of primary MNGSCT and developed the hematologic disorder a few months after local recurrence. In conclusion, the time elapsed from chemotherapy administration does not discriminate the hematologic neoplasms associated to MNGSCT from those related to therapy.

scholarly journals Surgical controversies in the management of post-chemotherapy nonretroperitoneal residual disease in metastatic nonseminomatous germ cell tumors

2016 ◽  
Vol 05 (01) ◽  
pp. 20-22 ◽  
Author(s):  
Durgatosh Pandey ◽  
Pankaj Kumar Garg ◽  
Mukur Dipi Ray ◽  
Ashutosh Mishra
Keyword(s):  
Germ Cell ◽  
Residual Disease ◽  
Histopathological Examination ◽  
Germ Cell Tumors ◽  
Surgical Excision ◽  
Adjunct Treatment ◽  
Platinum Based Chemotherapy ◽  
Number Of Patients ◽  
Nonseminomatous Germ Cell Tumors

AbstractFollowing the advent of platinum-based chemotherapy, Surgery, excepting orchidectomy, has become an adjunct treatment in the management of metastatic non-seminomatous germ cell tumors (NSGCT). Role of surgery comes into play in metastatic NSGCT when residual disease persists following standard chemotherapy. Surgical excision of all post chemotherapy residual disease at all places, whenever surgically feasible with acceptable morbidity and mortality, should be undertaken. As histopathological examination of the excised postchemotherapy residue shows only necrosis and fibrosis in significant number of patients; surgical exercise in this group of patients seems futile and unwarranted retrospectively. This issue becomes more contentious when surgeons are confronted with multiple nonretroperitoneal post chemotherapy residues. This article aims to deal with the management of postchemotherapy nonretroperitoneal residues in metastatic NSGCT.

843 Role of surgery in patients with liver metastases from nonseminomatous germ cell tumors

2003 ◽  
Vol 1 (5) ◽  
pp. S254
Author(s):  
J.T. Hartmann ◽  
O. Rick ◽  
K. Oechsie ◽  
T. Gauler ◽  
P. Schoeffski ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Nonseminomatous Germ Cell Tumors

scholarly journals Pleural and pulmonary metastases from nonseminomatous germ cell tumors successfully managed by extrapleural pneumonectomy

2021 ◽  
Author(s):  
Hinata Matsuda ◽  
Tomonori Minagawa ◽  
Hiroyuki Agatsuma ◽  
Takeshi Uehara ◽  
Haruhiko Utazu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Pulmonary Metastases ◽  
Germ Cell Tumors ◽  
Extrapleural Pneumonectomy ◽  
Nonseminomatous Germ Cell Tumors
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