Potential adverse effect of semen processing on human sperm deoxyribonucleic acid integrity

1999 ◽  
Vol 72 (3) ◽  
pp. 496-499 ◽  
Author(s):  
Armand Zini ◽  
Victor Mak ◽  
Donna Phang ◽  
Keith Jarvi
Keyword(s):  
Adverse Effect ◽  
Deoxyribonucleic Acid ◽  
Human Sperm ◽  
Potential Adverse Effect ◽  
Semen Processing

ADVERSE EFFECT OF SEMEN PROCESSING ON HUMAN SPERM DNA INTEGRITY

1999 ◽  
pp. 282
Author(s):  
Victor Mak ◽  
Keith Jarvi ◽  
Donna Phang ◽  
Martin Buckspan ◽  
Armand Zini
Keyword(s):  
Adverse Effect ◽  
Human Sperm ◽  
Dna Integrity ◽  
Sperm Dna Integrity ◽  
Sperm Dna ◽  
Semen Processing

scholarly journals Paliperidone induced neutropenia in first episode psychosis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Natalie Martos ◽  
William Hall ◽  
Alicia Marhefka ◽  
Thomas W. Sedlak ◽  
Frederick C. Nucifora
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
The United States ◽  
First Episode Psychosis ◽  
Potential Adverse Effect ◽  
Severe Neutropenia ◽  
First Episode ◽  
Antipsychotic Medications ◽  
Increased Risk ◽  
Episode Psychosis

Abstract Background Neutropenia, a decrease in total number of neutrophils below 1500/mm3 and particularly severe neutropenia, defined as neutrophils less than 500/mm3, is a potential adverse effect of antipsychotic medications that can lead to increased risk of infections and death. However, much of the attention on the potential adverse effect is centered exclusively on clozapine, which remains the only antipsychotic medication in the United States requiring standardized monitoring of blood work. We demonstrate here that paliperidone can also cause neutropenia and therefore clinicians should be aware of this possibility especially during initiation of treatment. Case presentation The following report presents the case of a 23-year-old African American male with first episode psychosis who developed neutropenia after initiation of paliperidone. Neutropenia resolved after discontinuation of paliperidone and initiation of an alternative antipsychotic, haloperidol. Conclusions This case report demonstrates an example of paliperidone induced neutropenia which resolved with a switch to haloperidol. We conclude that when initiating paliperidone, clinicians should be more aware of the risk of neutropenia. Moreover, neutropenia may be a more common and overlooked issue in patients on antipsychotic medications other than clozapine and increased awareness of comparative risk across antipsychotics could help direct treatment.

scholarly journals Alopecia After Switch to Tenofovir Alafenamide in 6 African American Women

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Said El Zein ◽  
Hussam Tabaja ◽  
Amjad Kanj ◽  
Deborah Richmond ◽  
Jennifer Veltman
Keyword(s):  
Adverse Effect ◽  
African American ◽  
African American Women ◽  
Hair Loss ◽  
Potential Adverse Effect ◽  
African American Female ◽  
American Women ◽  
Female Patients ◽  
Tenofovir Alafenamide

Abstract No cases of tenofovir alafenamide (TAF)–induced alopecia have been reported in the literature. We describe 6 cases of hair loss in African American female patients after switching to TAF and aim to raise awareness about this potential adverse effect of TAF, which could predominate in certain patient populations.

scholarly journals Acne as a Potential Adverse Effect of Duloxetine

2014 ◽  
Vol 24 (4) ◽  
pp. 408-410 ◽  
Author(s):  
Martin A. Katzman ◽  
Melissa Furtado ◽  
Leena Anand
Keyword(s):  
Adverse Effect ◽  
Potential Adverse Effect

scholarly journals Measurement of mammalian sperm deoxyribonucleic acid by flow cytometry. Problems and approaches.

1977 ◽  
Vol 25 (7) ◽  
pp. 763-773 ◽  
Author(s):  
M A Van Dilla ◽  
B L Gledhill ◽  
S Lake ◽  
P N Dean ◽  
J W Gray ◽  
...  
Keyword(s):  
Deoxyribonucleic Acid ◽  
Human Sperm ◽  
Test System ◽  
Index Of Refraction ◽  
Lateral Extension ◽  
Mammalian Sperm ◽  
Y Chromosomes ◽  
Coefficients Of Variation ◽  
Flat Shape ◽  
The Right

Measurement of mammalian sperm deoxyribonucleic acid content is of importance in several areas of biomedical research. When measured in flow systems with orthogonal axes of illumination, flow and detection, an unexpected, distorted distribution consisting of a narrow peak with a lateral extension to the right is observed. Several lines of evidence lead to the conclusion that this effect is an optical-geometric artifact attributable to the flat shape and high index of refraction of mammalian sperm heads. This artifact disappears when an epiillumination flow system is used in which the optic axes for illumination and detection and the flow axis are all coincident. Other approaches also eliminate the artifact. The resulting coefficients of variation observed after acriflavine-Feulgen staining are 4-5%, short of the goal of 1.5% required to distinguish between human sperm bearing X and Y chromosomes and to develop a mutagen test system using mice.

scholarly journals Is small mammal mycophagy relevant for truffle cultivation?

2013 ◽  
Vol 47 (2) ◽  
pp. 139-143 ◽  
Author(s):  
Alexander Urban ◽  
Marija Kataržytė ◽  
Susanne Schickman ◽  
Katharina Kräutler ◽  
Tony Pla
Keyword(s):  
Adverse Effect ◽  
Small Mammal ◽  
Potential Role ◽  
Potential Adverse Effect ◽  
Hypogeous Fungi ◽  
Truffle Cultivation

The role of small mammal mycophagy as vectors of hypogeous fungi is well established. However, little is known about dispersal of gourmet truffle species by mammal vectors, or about the potential role of mycophagy in truffle plantations. We hypothesize that small mammal mycophagy contributes to the productivity of truffle plantations by providing inoculum for truffle mycelium establishment and mating. Spread of non-desired competitors of gourmet truffles is a potential adverse effect of small mammal mycophagy.

scholarly journals Efficacy of antiviral therapy in patients with post-hepatitis C liver cirrhosis: is hyperuricaemia a potential adverse effect?

2020 ◽  
Vol 7 (1) ◽  
pp. e000533
Author(s):  
Amr Elsayed ◽  
Ehab M Abdelraheem ◽  
Hatem Hassan ◽  
Abbas Abbas ◽  
Alshymaa Hassnine
Keyword(s):  
Adverse Effect ◽  
Uric Acid ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Response To Treatment ◽  
Potential Adverse Effect ◽  
Hcv Rna ◽  
Genotype 4 ◽  
Major Health Problem

Hepatitis C virus (HCV) related liver cirrhosis is considered a major health problem; sofosbuvir (SOF)/ledipasvir (LDV) and SOF/daclatsvir (DACLA) are very promising direct antiviral agents (DAAS) especially in treating HCV genotype 4 which is the main genotype in Egypt. Uric acid elevation was reported in many systemic diseases and might be elevated during direct antiviral therapy. The aim is to evaluate efficacy and safety of SOF/LDV and SOF/DACLA plus ribavirin in treating HCV related child A liver cirrhosis and assess hyperuricaemia as a potential adverse effect to this regimen.MethodsThis prospective observatinal study included 128 HCV naive child A cirrhotic patients divided into two groups (77 patients were treated with SOF 400 mg, DACLA 60 mg and ribavirin 600 mg and 51 patients were treated with SOF 400 mg, LDV 90 mg and ribavirin 600 mg) for 12 weeks, during the treatment complete blood count, creatinine, bilirubin, alanine transaminase, aspartate transaminase and serum uric acid were monitored, HCV RNA quantitative PCR at 12 weeks after the end of treatment was done.ResultsResponse to treatment in SOF/LDV (sof/led) group is about (98%), response to treatment in SOF/DACLA (sof/dacla) group is about (96%). Hyperuricaemia was noticed in 17.6% of patients received sof/led and in 15.5% of those received sof/dacla.ConclusionSOF+LDV and SOF+DACLA plus ribavirin regimens are highly effective in treating chronic HCV patients with compensated liver cirrhosis. Hyperuricaemia is considered a potential adverse effect to DAAS containing ribavirin and may lead to serious side effects such as renal impairment.

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