Oxidative stress in families of type 1 diabetic patients

2000 ◽  
Vol 151 (1) ◽  
pp. 15-16
Author(s):  
E Matteucci ◽  
V Cinapri ◽  
S Quilici ◽  
G Forotti ◽  
O Giampietro
Keyword(s):  
Oxidative Stress ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes

2020 ◽  
Vol 9 (7) ◽  
pp. 2155
Author(s):  
Francesca Iannantuoni ◽  
Aranzazu M. de Marañon ◽  
Zaida Abad-Jiménez ◽  
Francisco Canet ◽  
Pedro Díaz-Pozo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Adhesion Molecules ◽  
Mitochondrial Function ◽  
Mitochondrial Membrane ◽  
Diabetic Patients ◽  
Ros Production ◽  
Mitochondrial Ros ◽  
Type 1 Diabetic Patients

Type 1 diabetes has been associated with oxidative stress. This study evaluates the rates of oxidative stress, mitochondrial function, leukocyte–endothelium interactions and adhesion molecules in type 1 diabetic patients. The study population consisted of 52 diabetic patients and 46 body-composition and age-matched controls. We assessed anthropometric and metabolic parameters, oxidative stress and mitochondrial function by evaluating reactive oxygen species (ROS) production, mitochondrial ROS production, mitochondrial membrane potential and superoxide dismutase (SOD) and catalase (CAT) expression in polymorphonuclear leukocytes from type 1 diabetic patients. In addition, we evaluated interactions between leukocytes and human umbilical vein endothelial cells (HUVEC), and serum expression of adhesion molecules (P-selectin, VCAM-1 and ICAM-1), proinflammatory cytokines (IL-6 and TNFα) and myeloperoxidase (MPO). HbA1C and glucose levels were higher in diabetic patients than in control subjects, as expected. Mitochondrial function was altered and leukocyte–endothelium interactions were enhanced in diabetic patients, which was evident in the increase in total and mitochondrial ROS production, higher mitochondrial membrane potential, enhanced leukocyte rolling and adhesion, and decreased rolling velocity. Furthermore, we observed an increase in levels of adhesion molecules P-selectin, VCAM-1, and ICAM-1 in these subjects. In addition, type 1 diabetic patients exhibited an increase in proinflammatory mediators TNFα and MPO, and a decreased expression of SOD. The enhancement of leukocyte–endothelium interactions and proinflammatory markers correlated with glucose and HbA1Clevels. Mitochondrial alteration, oxidative stress, and enhanced leukocyte–endothelium interactions are features of type 1 diabetes and may be related to cardiovascular implications.

Oxidative stress in families of type 1 diabetic patients

2000 ◽  
Vol 50 ◽  
pp. 308 ◽  
Author(s):  
E Matteucci ◽  
V Cinapri ◽  
S Quilici ◽  
G Forotti ◽  
O Giampietro
Keyword(s):  
Oxidative Stress ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

The Relationship of Oxidative Stress to Thrombotic Tendency in Type 1 Diabetic Patients with Retinopathy

1991 ◽  
Vol 8 (9) ◽  
pp. 860-865 ◽  
Author(s):  
P. E. Jennings ◽  
M. McLaren ◽  
N. A. Scott ◽  
A. R. Saniabadi ◽  
J. J. F. Belch
Keyword(s):  
Oxidative Stress ◽  
Diabetic Patients ◽  
Relationship Of ◽  
Type 1 Diabetic Patients ◽  
The Relationship ◽  
Thrombotic Tendency

scholarly journals Oxidative stress in families of type 1 diabetic patients

Diabetes Care ◽  
2000 ◽  
Vol 23 (8) ◽  
pp. 1182-1186 ◽  
Author(s):  
E. Matteucci ◽  
O. Giampietro
Keyword(s):  
Oxidative Stress ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Assessment the effects of insulin on adiponectin, nitric oxide, myeloperoxidase and lipid profile in type 1 diabetic patients

Pharmacia ◽  
2021 ◽  
Vol 68 (2) ◽  
pp. 313-319
Author(s):  
Jehan A. Mohammad ◽  
Zainab H. Fathi ◽  
Thikra Ali Allwash
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Lipid Profile ◽  
Serum Levels ◽  
Serum Glucose ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

Type 1 diabetes (T1DM) is well recognized risk factor cardiovascular disease (CVD). Insulin therapy is recommended for all patients with type 1 diabetes. Previous findings showed that diabetes impairs endothelial function and increased glucose level reduces nitric oxide (NO) output and increases myeloperoxidase (MPO) activity. However, adiponectin (APN) decreases serum glucose levels. The current study evaluated effects of insulin therapy on circulating levels of oxidative stress and CVD biomarkers like NO, APN, MPO, AIP and lipid profile in type 1 diabetic patients. Fifty patients with T1DM and 18 healthy people were enrolled in this study. The recruited people with T1DM were classified into two groups: 22 newly diagnosed (untreated) type 1 diabetic patients and 28 insulin treated patients. In all groups, circulating NO, APN, MPO, AIP and lipids levels were measured. Compared to control, untreated diabetes revealed a significant increase in the serum levels of APN, MPO, TG, VLDL, TC, LDL and AIP, with a marked reduction in NO and HDL levels. However, insulin therapy significantly lowered MPO, TC and LDL, with no significant changes in the other biochemical parameters. As expected, oxidative stress and CVD-associated markers were significantly increased in untreated diabetes. Insulin therapy exhibited a relatively positive effect on oxidative stress and CVD biomarkers. Accordingly, insulin plus antioxidant supplementation required to normalize these parameters.

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