scholarly journals The mechanism of inactivation of dopamine beta-hydroxylase by hydrazines.

1986 ◽  
Vol 261 (10) ◽  
pp. 4510-4518 ◽  
Author(s):  
P F Fitzpatrick ◽  
J J Villafranca
Keyword(s):  
Dopamine Beta Hydroxylase

scholarly journals Kinetic and spectroscopic studies of the interaction of copper with dopamine beta-hydroxylase.

1984 ◽  
Vol 259 (6) ◽  
pp. 3395-3398 ◽  
Author(s):  
D E Ash ◽  
N J Papadopoulos ◽  
G Colombo ◽  
J J Villafranca
Keyword(s):  
Spectroscopic Studies ◽  
Dopamine Beta Hydroxylase

Sympathetic input to ganglia of the guinea pig sphincter of Oddi

1994 ◽  
Vol 266 (6) ◽  
pp. G1162-G1169 ◽  
Author(s):  
D. G. Wells ◽  
G. M. Mawe
Keyword(s):  
Sphincter Of Oddi ◽  
Nerve Fibers ◽  
Excitatory Postsynaptic Potential ◽  
Inhibitory Neurotransmitter ◽  
Fiber Tracts ◽  
Inhibitory Postsynaptic Potentials ◽  
Dopamine Beta Hydroxylase ◽  
Staining Techniques ◽  
The Uk ◽  
Ganglionated Plexus

Intracellular recording and immunohistochemical staining techniques were used to establish whether sphincter of Oddi (SO) ganglia are a target of sympathetic input to this region. Norepinephrine (0.01-10.0 microM) decreased the amplitude of the nicotinic fast excitatory postsynaptic potential (EPSP) evoked by stimulation of interganglionic fiber tracts, with a half-maximal inhibitory concentration (EC50) of 300 nM. Norepinephrine did not alter the responsiveness of the neurons to acetylcholine. The alpha 2-adrenoreceptor agonist UK-14304 mimicked the norepinephrine-induced effect with a EC50 of 2.5 nM, whereas alpha 1- and beta-adrenoreceptor agonists had no effect on the EPSP. The alpha 2-adrenoreceptor antagonist idazoxan (1.0 microM) inhibited the UK-14304 response, with a dissociation constant of 1.0 nM. Release of endogenous catecholamines, by the addition of tyramine (100 microM) to the bath, caused an idazoxan-sensitive decrease in the amplitude of the fast EPSP. In the minority of SO neurons that exhibited inhibitory postsynaptic potentials (IPSPs), norepinephrine caused a hyperpolarization of the membrane potential. The IPSP and the norepinephrine-induced hyperpolarization were inhibited by alpha 2-adrenoreceptor antagonists. Desipramine (1.0 microM), an uptake inhibitor, reversibly increased the amplitude of the IPSP. Immunoreactivities for tyrosine hydroxylase and dopamine beta-hydroxylase were coexistent in nerve fibers and nonexistent in cell bodies in the ganglionated plexus of the SO. The results of this study indicate that norepinephrine acts pre- and postsynaptically as an inhibitory neurotransmitter in SO ganglia.

Plasma Noradrenaline and Dopamine-Beta-Hydroxylase During Sexual Activity

1977 ◽  
Vol 39 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Claus Wiedeking ◽  
Raymond C. Lake ◽  
Michael Ziegler ◽  
Avinoam A. Kowarski ◽  
John Money
Keyword(s):  
Sexual Activity ◽  
Plasma Noradrenaline ◽  
Dopamine Beta Hydroxylase
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