scholarly journals Modulation of apolipoprotein B antigenic determinants in human low density lipoprotein subclasses.

1985 ◽  
Vol 260 (8) ◽  
pp. 5067-5072 ◽  
Author(s):  
B Teng ◽  
A Sniderman ◽  
R M Krauss ◽  
P O Kwiterovich ◽  
R W Milne ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Antigenic Determinants ◽  
Low Density ◽  
Lipoprotein Subclasses

scholarly journals Reduced β-strand content in apoprotein B-100 in smaller and denser low-density lipoprotein subclasses as probed by Fourier-transform infrared spectroscopy

1997 ◽  
Vol 322 (3) ◽  
pp. 765-769 ◽  
Author(s):  
Fabio TANFANI ◽  
Tiziana GALEAZZI ◽  
Giovanna CURATOLA ◽  
Enrico BERTOLI ◽  
Gianna FERRETTI
Keyword(s):  
Fourier Transform ◽  
Secondary Structure ◽  
Apolipoprotein B ◽  
Gradient Centrifugation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Subclasses ◽  
Ldl Particles ◽  
Ldl Subfractions

The secondary structure of apolipoprotein B-100 in low-density lipoprotein (LDL) subfractions was analysed by Fourier-transform IR spectroscopy. LDLs were isolated in three density ranges by gradient centrifugation of human plasma from healthy volunteers. The spectra revealed differences in the lipid content and composition of the three LDL fractions. The secondary structure of apolipoprotein B-100 was the same in the two fractions corresponding to the large less-dense LDL particles, whereas a lower content of β-strands was found in the third fraction corresponding to the smaller denser LDL particles. Analysis of the spectroscopic data suggests that, in the same set of LDL subfractions, the particle size is probably the cause of the observed differences in apolipoprotein B-100 secondary structure.

scholarly journals Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 ◽  
Vol 234 (1) ◽  
pp. 245-248 ◽  
Author(s):  
W Jessup ◽  
G Jurgens ◽  
J Lang ◽  
H Esterbauer ◽  
R T Dean
Keyword(s):  
Apolipoprotein B ◽  
Negative Charge ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipid Peroxidation Product ◽  
Modified Low Density Lipoproteins ◽  
Peroxidation Product

The incorporation of the lipid peroxidation product 4-hydroxynonenal into low-density lipoprotein (LDL) increases the negative charge of the particle, and decreases its affinity for the fibroblast LDL receptor. It is suggested that this modification may occur in vivo, and might promote atherogenesis.

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