Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-5α-cholestan-15-one and its 14β-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

10.1016/0009-3084(94)90106-6 ◽

1994 ◽

Vol 74 (1) ◽

pp. 1-15 ◽

Cited By ~ 4

Author(s):

Abdul U. Siddiqui ◽

William K. Wilson ◽

Edward J. Parish ◽

Nicolas Gerst ◽

Frederick D. Pinkerton ◽

...

Keyword(s):

Spectral Properties ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3β-hydroxy-25,26,26,26,27,27,27-heptafluoro-5α-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells

10.1016/0009-3084(94)90017-5 ◽

1994 ◽

Vol 72 (1) ◽

pp. 59-75 ◽

Cited By ~ 5

Author(s):

Abdul U. Siddiqui ◽

Shankar Swaminathan ◽

Frederick D. Pinkerton ◽

Nicolas Gerst ◽

William K. Wilson ◽

...

Keyword(s):

Mammalian Cells ◽

Spectral Properties ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Derivatives Of ◽

Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5α-cholest-8(14)-ene-3β,15β,26-triol, a potential metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells

10.1016/0009-3084(92)90103-v ◽

1992 ◽

Vol 61 (3) ◽

pp. 235-242 ◽

Cited By ~ 6

Author(s):

Shankar Swaminathan ◽

Frederick D. Pinkerton ◽

William K. Wilson ◽

George J. Schroepfer

Keyword(s):

Chemical Synthesis ◽

Spectral Properties ◽

Coenzyme A ◽

Sterol Synthesis ◽

Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3β-hydroxy-5α-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells

10.1016/0009-3084(92)90025-k ◽

1992 ◽

Vol 63 (1-2) ◽

pp. 77-90 ◽

Cited By ~ 9

Author(s):

Abdul U. Siddiqui ◽

William K. Wilson ◽

Karen E. Ruecker ◽

Frederick D. Pinkerton ◽

George J. Schroepfer

Keyword(s):

Spectral Properties ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Derivatives Of ◽

Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)35743-6 ◽

1993 ◽

Vol 34 (10) ◽

pp. 1805-1823 ◽

Cited By ~ 1

Author(s):

S Swaminathan ◽

WK Wilson ◽

FD Pinkerton ◽

N Gerst ◽

M Ramser ◽

...

Keyword(s):

Chemical Synthesis ◽

Mammalian Cells ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)38318-8 ◽

1989 ◽

Vol 30 (6) ◽

pp. 919-928

Author(s):

W K Wilson ◽

F D Pinkerton ◽

N D Kirkpatrick ◽

G J Schroepfer

Keyword(s):

Chemical Synthesis ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and sterol synthesis by cholesterol sulfate in cultured fibroblasts

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/0167-4889(85)90198-3 ◽

1985 ◽

Vol 845 (3) ◽

pp. 349-357 ◽

Cited By ~ 42

Author(s):

Mary L. Williams ◽

Millie Hughes-Fulford ◽

Peter M. Elias

Keyword(s):

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Cholesterol Sulfate ◽

Cultured Fibroblasts ◽

Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in CHO-K1 cells

Steroids ◽

10.1016/0039-128x(94)90119-8 ◽

1994 ◽

Vol 59 (5) ◽

pp. 310-317 ◽

Cited By ~ 9

Author(s):

William K. Wilson ◽

Shankar Swaminathan ◽

Frederick D. Pinkerton ◽

Nicolas Gerst ◽

George J. Schroepfer

Keyword(s):

Carbon Atom ◽

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Fluorine Substitution ◽

Inhibitors of sterol synthesis. Chemical synthesis of 7α-ethyl and 16α-ethyl derivatives of Δ8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells

10.1016/0009-3084(92)90054-s ◽

1992 ◽

Vol 62 (1) ◽

pp. 55-67 ◽

Cited By ~ 7

Author(s):

Hong-Seok Kim ◽

William K. Wilson ◽

Nanda Duhé Kirkpatrick ◽

Frederick D. Pinkerton ◽

Shankar Swaminathan ◽

...

Keyword(s):

Chemical Synthesis ◽

Coenzyme A ◽

Sterol Synthesis ◽

Derivatives Of ◽

Evidence that changes in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity are required partly to maintain a constant rate of sterol synthesis.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)42613-5 ◽

1984 ◽

Vol 259 (23) ◽

pp. 14399-14405

Author(s):

G F Gibbons ◽

O G Björnsson ◽

C R Pullinger

Keyword(s):

Coenzyme A ◽

Reductase Activity ◽

Sterol Synthesis ◽

Constant Rate ◽