1451 The excessive daytime sleepiness and nocturnal sleep disturbance associated with recent onset narcolepsy respond to intravenous immunoglobulin

2005 ◽  
Vol 238 ◽  
pp. S468
Keyword(s):  
Sleep Disturbance ◽  
Intravenous Immunoglobulin ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Nocturnal Sleep ◽  
Recent Onset

scholarly journals Excessive daytime sleepiness, nocturnal sleep duration and psychopathology among Nigerian university students

2011 ◽  
Vol 17 (4) ◽  
pp. 4 ◽  
Author(s):  
Celestine Okorome Mume ◽  
Kamildeen Oladimeji Olawale ◽  
Adeagbo Funminiyi Osundina
Keyword(s):  
University Students ◽  
Sleep Duration ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
English Language ◽  
General Health Questionnaire ◽  
Nocturnal Sleep ◽  
General Psychopathology ◽  
Language Version ◽  
Nigerian University

<p><strong>Background and objectives.</strong> Short nocturnal sleep duration resulting in sleep debt may be a cause of excessive daytime sleepiness (EDS). Severity of depression (psychopathology) has been found to be directly related to EDS. There is an association between sleep duration and mental health, so there may therefore be an interrelationship between sleep duration, EDS and psychopathology. The objectives of this study were to determine the prevalence rates of EDS and general psychopathology among university students in Nigeria; determine the range of and mean sleep duration in the students; and determine the extent to which sleep duration and EDS predict general psychopathology in the same group of subjects. Materials and methods. Eight hundred and forty-five students at Obafemi Awolowo University, Ile-Ife, Nigeria, were recruited for the study. The subjects were required to provide information on their age, gender and the total amount of sleep per night they usually had. General psychopathology was assessed using the English language version of the 30-item General Health Questionnaire (GHQ-30). They were also evaluated for EDS using the English language version of the Epworth Sleepiness Scale (ESS).</p><p><strong>Results.</strong> Six hundred and thirty-four subjects (75.03% of the participants) provided complete data. The prevalence of EDS was 11.2% and the rate of general psychopathology in the subjects 13.1%. The range of sleep duration was 2 - 9 hours with a mean of 5.1 hours (standard deviation 1.3). On a regression model with the GHQ score as the dependent variable and sleep duration and ESS as the independent variables, the correlation coefficient between EDS, sleep duration and psychopathology (R) was 0.47.</p><p><strong>Conclusion.</strong> EDS and psychopathology are common in the student population studied. Nocturnal sleep duration for an average student is far less than that for an average adult. Nocturnal sleep duration and EDS acted as moderate predictors of general psychopathology among Nigerian university students.</p>

Sleep and pregnancy

2018 ◽  
Author(s):  
Michele L. Okun
Keyword(s):  
Sleep Disturbance ◽  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Lifestyle Changes ◽  
Sleep Maintenance ◽  
Increased Risk ◽  
Exogenous Factors ◽  
Adverse Pregnancy

Pregnant women experience a greater degree of sleep disturbance than their non-pregnant counterparts. Complaints range from sleep maintenance issues to excessive daytime sleepiness. Emerging evidence suggests that there is variability in sleep patterns and complaints which manifest differently among pregnant women. Moreover, it is well accepted that sleep disturbance can dysregulate normal immune and endocrine processes that are critically important to the health and progression of gestation. A possible consequence of sleep disturbance is an increased risk for adverse pregnancy outcomes. Then again, many endogenous and exogenous factors, including pregnancy-related physiological, hormonal, and anatomic changes, as well as lifestyle changes, can impact the degree and chronicity of sleep disturbance. Alas, there is still much to learn in terms of what women can/should expect with regard to the timing, degree, frequency, and/or severity of a specific pregnancy-related sleep disturbance(s), despite the number of published studies evaluating what sleep during pregnancy encompasses.

scholarly journals Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

1997 ◽  
Vol 82 (5) ◽  
pp. 1313-1316 ◽  
Author(s):  
Alexandros N. Vgontzas ◽  
Dimitris A. Papanicolaou ◽  
Edward O. Bixler ◽  
Anthony Kales ◽  
Kathy Tyson ◽  
...  
Keyword(s):  
Sleep Disturbance ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Plasma Cytokines

Sleep and fatigue in multiple sclerosis

2006 ◽  
Vol 12 (4) ◽  
pp. 481-486 ◽  
Author(s):  
B R Stanton ◽  
F Barnes ◽  
E Silber
Keyword(s):  
Multiple Sclerosis ◽  
Sleep Disturbance ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sleep Problems ◽  
Sleep Diary ◽  
Severity Scale ◽  
Different Types ◽  
Fatigue Severity ◽  
The Relationship

Fatigue is common in multiple sclerosis (MS) and is an important cause of disability. However, the cause of fatigue is poorly understood. This study aimed to describe the frequency and pattern of sleep disturbance in a group of outpatients with MS, and to investigate the relationship between sleep disturbance and fatigue. Sixty outpatients with MS completed the Fatigue Severity Scale (FSS) and the Epworth Sleepiness Scale and kept a sleep diary for seven days. Fatigue and excessive daytime sleepiness were common in this group of patients (64 and 32%). Sleep problems on at least two nights per week occurred frequently, including initial insomnia in 42%, middle insomnia in 53% and terminal insomnia in 58%. The reasons cited for different types of insomnia varied, with anxiety and pain/discomfort being the commonest causes of initial insomnia and nocturia the commonest cause of middle insomnia. Middle insomnia was significantly correlated with daytime fatigue, a relationship that remained after controlling for disability. Sleep disturbance is common in MS and is associated with treatable symptoms, including pain and nocturia. Sleep disturbance may be an important factor contributing to fatigue in patients with MS.

scholarly journals Clinical long-term nocturnal sleeping disturbances and excessive daytime sleepiness in Parkinson’s disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259935
Author(s):  
Rocio Del Pino ◽  
Ane Murueta-Goyena ◽  
Unai Ayala ◽  
Marian Acera ◽  
Mónica Fernández ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Motor Impairment ◽  
Nocturnal Sleep ◽  
Nocturnal Problems ◽  
Over Time

Objective To prospectively evaluate nocturnal sleep problems and excessive daytime sleepiness (EDS) in Parkinson’s disease (PD) patients, and analyze the influence of motor symptoms, treatment, and sex differences on sleep problems in PD. Methods Sleep disturbances of 103 PD patients were assessed with Parkinson’s Disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale (ESS). Student’s t-test for related samples, one-way ANOVA with Tukey’s HSD post hoc test were used to assess group differences. Bivariate correlations and mixed-effects linear regression models were used to analyze the association between clinical aspects and sleep disturbances over time. Results At baseline, 48.5% of PD patients presented nocturnal problems and 40% of patients presented EDS. The PDSS and ESS total score slightly improve over time. Nocturnal problems were associated with age and motor impartment, explaining the 51% of the variance of the PDSS model. Males presented less nocturnal disturbances and more EDS than females. Higher motor impairment and combined treatment (L-dopa and agonist) were related to more EDS, while disease duration and L-dopa in monotherapy were related to lower scores, explaining the 59% of the model. Conclusions Sleep disturbances changed over time and age, diseases duration, motor impairment, treatment and sex were associated with nocturnal sleep problems and EDS. Agonist treatment alone or in combination with L-dopa might predict worse daytime sleepiness, while L-dopa in monotherapy is related to lower EDS, which significantly affects the quality of life of PD patients.

scholarly journals 0756 A One Year Observational Early Access Pitolisant Study of Excessive Daytime Sleepiness in Narcolepsy

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A287-A288
Author(s):  
D J Stultz ◽  
S Osburn ◽  
T Burns ◽  
N Stanley ◽  
R Walton ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sodium Oxybate ◽  
Average Score ◽  
Sleep Paralysis ◽  
Nocturnal Sleep ◽  
Early Access ◽  
History Of ◽  
One Year

Abstract Introduction Pitolisant is a H3 receptor antagonist/inverse agonist that has been FDA approved for excessive daytime sleepiness in narcolepsy at doses of either 17.8 mg or 35.6 mg per day. Methods 13 patients (3 males and 10 females) were studied having an average age of 46.8 years, with the majority receiving a dose of 35.6 mg Pitolisant. One patient received 17.8 mg throughout the year, and another advanced after 6 months to the 35.6 mg dose due to hepatic issues. 12 of the patients were Caucasian and one was Asian. 100% of the patients had co-existing sleep and psychiatric disorders. 46% had co-existing sleep apnea and were on CPAP/BIPAP. 38.5% had a history of a head injury. 84.6% of the patients had associated cataplexy, 38% had sleep paralysis, 92% had disrupted nocturnal sleep, and 46% had hypnogogic hallucinations. Throughout the year the patients were monitored using the Epworth Sleepiness Scale (ESS). Nine patients completed the 12-month ESS scales. 12/13 were on other medications to treat narcolepsy prior to starting Pitolisant. 6/13 were on sodium oxybate, 7/13 were on an antidepressant, and 11/13 were on either a stimulant, modafanil, or armodafanil. Only one patient was on Pitolisant alone. Results The patient’s average ESS score at onset was 16.2 Statistically significant findings using paired t-tests were documented. After one-month ESS scores decreased to an average of 13.2 (t=2.38, 9df, P=.04). At 3 months it was 12.4 (t=2.81, 10df, P=.02), at 6 months it was 12.75 (t=4.69, 11df, P&lt;.001) and at 12 months the average score was 13.11 (t=2.55, 8df, P=.03) documenting clinically meaningful decrease of ESS by &gt;/= 3 points. Three patients had ESS scores &lt;/=10 at 12 months. Conclusion Improvement on ESS was documented at one month and sustained for one year in patients diagnosed with having narcolepsy both with and without cataplexy. Support **No support was given for this study. Dr. Stultz is a speaker for Harmony Biosciences and has served on their advisory committee. She is also a speaker for Jazz Pharmaceuticals.

scholarly journals Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease

2018 ◽  
Vol 75 (1) ◽  
pp. 114 ◽  
Author(s):  
Fabian Büchele ◽  
Marc Hackius ◽  
Sebastian R. Schreglmann ◽  
Wolfgang Omlor ◽  
Esther Werth ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Sleep Disturbance ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sodium Oxybate
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