Roles of 5-HT3 and opioid receptors in the ethanol-induced place preference in rats exposed to conditioned fear stress

Life Sciences ◽  
1999 ◽  
Vol 64 (21) ◽  
pp. PL241-PL249 ◽  
Author(s):  
Shigeki Matsuzawa ◽  
Tsutomu Suzuki ◽  
Miwa Misawa ◽  
Hiroshi Nagase
Keyword(s):  
Opioid Receptors ◽  
Conditioned Fear ◽  
Place Preference ◽  
Conditioned Fear Stress

Conditioned fear stress induces ethanol-associated place preference in rats

1998 ◽  
Vol 341 (2-3) ◽  
pp. 127-130 ◽  
Author(s):  
Shigeki Matsuzawa ◽  
Tsutomu Suzuki ◽  
Miwa Misawa
Keyword(s):  
Conditioned Fear ◽  
Place Preference ◽  
Conditioned Fear Stress

Semi-synthesis of Novel Buprenorphine Derivatives and their Anti-nociceptive Properties and Dependency Potential

2021 ◽  
Author(s):  
Zahra Hasanpour ◽  
Peyman Salehi ◽  
Lennart Bunch ◽  
Mona Khoramjouy ◽  
Morteza Bararjanian ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Analgesic Effect ◽  
Preference Test ◽  
Biological Properties ◽  
Place Preference ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Active Compounds ◽  
Methyl Group ◽  
Analgesic Activities

Abstract: Novel 1,2,3-triazole-tethered N-norbuprenorphine derivatives with an OMe or OH group at the C3 position were synthesized alongside with evaluation of their analgesic properties. The analgesic activities of the resulting library were investigated via tail flick test in mice. Our results indicated that 10b and 10e were as effective as the starting compounds 8 and 9 with ED50 equal to 16.59 and 19.44 mg/kg, respectively. To investigate the effect of a methyl group at C3 on biological properties, the most active compounds were O-demethylated and their anti-nociceptive effects were assessed. The new O-demethylated derivatives (11b and 11e) showed better analgesic properties than the parent compounds with ED50 of 14.73 and 15.80 mg/kg, respectively. Naloxone prevented the analgesic effect of the synthesized compounds, indicating that the opioid receptors are highly involved in the anti-nociceptive effects of these. The potential dependency effects of the most potent derivatives were studied by condition place preference test in mice and compared to morphine and buprenorphine. Interestingly, 10b, 10e, 11b, and 11e did not show any dependency effect, similar to buprenorphine.

scholarly journals Effect of OPC-14523 on conditioned fear stress in mice

1998 ◽  
Vol 76 ◽  
pp. 195
Author(s):  
Sakiko Yamada ◽  
Katsura Tottori ◽  
Yasufumi Uwahodo ◽  
Takashi Miwa ◽  
Yasuo Oshiro ◽  
...  
Keyword(s):  
Conditioned Fear ◽  
Conditioned Fear Stress
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