Poor Outcomes Seen in Pregnancy-Tied Breast Ca

Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15-17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.

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Refractory convulsive syncope in pregnancy: a rare presentation of Takayasu’s arteritis - a case report and literature review

African Health Sciences ◽

10.4314/ahs.v21i2.46 ◽

2021 ◽

Vol 21 (2) ◽

pp. 852-857

Author(s):

Gasthony Alobo ◽

Violah Nahurira ◽

Venice Omona ◽

Pontius Bayo ◽

Sam Olum

Keyword(s):

Case Report ◽

Takayasu’S Arteritis ◽

Epileptic Seizures ◽

Lower Limbs ◽

Takayasu's Arteritis ◽

Rare Presentation ◽

Diagnostic Dilemma ◽

Poor Outcomes ◽

Convulsive Syncope ◽

In Pregnancy

Background: Neurological manifestation of Takayasu’s Arteritis (TA) in pregnancy presenting as convulsive syncope is extremely rare, and poses a serious diagnostic dilemma due to other vast causes of fits in pregnancy. Objective: We aimed to present and shed more light on a case of TA with convulsive syncope in pregnancy refractory to anticonvulsants for seven weeks, and review the literature on the management of TA in pregnancy. Case presentation: A gravida 4 para 3+0 at 28 weeks of amenorrhea presented with repeated episodes of the sudden loss of consciousness, followed by a fall and jerking of the limbs. These were refractory to anticonvulsants that she had used for seven weeks. Physical examination revealed undetectable pulse and blood pressure (BP) in the upper limbs but elevated BP in the lower limbs. Further investigations confirmed TA and she improved on steroids and antihypertensives. Conclusion: This case typically describes the unexpected presentation of TA with convulsive syncope. It calls for meticu- lous clinical assessment of epileptic seizures in pregnancy to avoid a late diagnosis of TA and its potential poor outcomes. Keywords: Takayasu’s Arteritis in pregnancy; convulsive syncope; case report.

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Pregnancies Complicated by Familial Hypertriglyceridemia: A Case Report

American Journal of Perinatology Reports ◽

10.1055/s-0038-1676832 ◽

2018 ◽

Vol 08 (04) ◽

pp. e362-e364

Author(s):

Suzanne Cao ◽

NhuChi Dao ◽

Kristina Roloff ◽

Guillermo Valenzuela

Keyword(s):

Diabetes Mellitus ◽

Case Report ◽

Diabetic Ketoacidosis ◽

Medication Compliance ◽

Severe Hypertriglyceridemia ◽

Life Threatening ◽

Poor Outcomes ◽

In Pregnancy

Background Although rare, familial hypertriglyceridemia can cause acute and life-threatening complications in pregnancy. Cases The first patient's pregnancy was complicated by multiple admissions for pancreatitis due to hypertriglyceridemia and noncompliance with gemfibrozil. In her second pregnancy, she was compliant with gemfibrozil and only experienced pancreatitis episodes toward the end of pregnancy. The second patient had diabetes mellitus and familial hypertriglyceridemia. She required multiple hospitalizations for diabetic ketoacidosis secondary to insulin noncompliance. In both pregnancies, she was compliant with gemfibrozil and had no complications related to hypertriglyceridemia. Conclusion Treatment with gemfibrozil in pregnancies complicated by hypertriglyceridemia may prevent complications without adverse maternal or fetal effects and could be considered in treating pregnant patients with severe hypertriglyceridemia. These cases also demonstrate the importance of medication compliance in the prevention of poor outcomes.

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Risk stratification for pregnancy-associated venous thromboembolism: Potential role for global coagulation assays

Obstetric Medicine ◽

10.1177/1753495x211025397 ◽

2021 ◽

pp. 1753495X2110253

Author(s):

David O’Keefe ◽

Hui Yin Lim ◽

Lisa Hui ◽

Prahlad Ho

Keyword(s):

Risk Assessment ◽

Venous Thromboembolism ◽

Potential Role ◽

Absolute Risk ◽

Holistic View ◽

Coagulation Assays ◽

High Quality Evidence ◽

Prediction And Prevention ◽

Poor Outcomes ◽

In Pregnancy

Risk assessment for venous thromboembolism in pregnancy and the puerperium is currently limited to stratifying clinical surrogate risk factors without high-quality evidence. While the absolute risk of pregnancy-associated venous thromboembolism is low for the vast majority of women, associated morbidity and mortality remains significant. As guidelines for thromboprophylaxis vary widely, some women may be under- or over-anticoagulated, contributing to poor outcomes. New global coagulation assays provide a holistic view of coagulation and may have the potential to detect hypercoagulability in pregnancy, unlike clinically available coagulation assays. However, there are major technical challenges to overcome before global coagulation assays can be realistically proposed as an adjunct to risk assessment for pregnancy-associated venous thromboembolism. This review summarises the literature and controversies in the prediction and prevention of pregnancy-associated venous thromboembolism and outlines the new tools in haematology that may assist in our future understanding of hypercoagulability in pregnancy.

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Serotonin transporter polymorphism and stress effects on gut microbiota at various time points in pregnancy

10.32469/10355/62053 ◽

2017 ◽

Author(s):

◽

Briana M. Kille

Keyword(s):

Prenatal Stress ◽

Gut Microbiome ◽

Good Evidence ◽

Potential Mechanism ◽

Time Points ◽

Stress Effects ◽

Serotonin Transporter Polymorphism ◽

Poor Outcomes ◽

Stress Susceptibility ◽

In Pregnancy

Prenatal stress (stress experienced by the mother while pregnant) has been shown to greatly affect the health of a child. Still, not all off05 who experience prenatal stress will suffer poor outcomes. Maternal genetics and the timing of adverse events have been shown to interact to affect the likelihood that a child will be affected by prenatal stress. However, the mechanisms behind this interaction are not fully understood. One potential mechanism is the maternal gut microbiome (the community of bacteria residing in the mother's gut). The current study used a mouse model of genetic stress susceptibility, combined with a daily restraint stress during pregnancy to examine alterations in the maternal gut microbiome due to an interaction between genes and stress. While pregnancy was found to alter the microbiome differently at various time-points in pregnancy, there was no significant interaction between genes and stress. However, as the sample size was quite small and there were trending results, we believe there is good evidence to continue exploration of the effects of stress and genetics on the maternal microbiome.

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A Rare Cause of Hemoperitoneum in Pregnancy

Acta Médica Portuguesa ◽

10.20344/amp.12835 ◽

2022 ◽

Vol 35 (1) ◽

pp. 59

Author(s):

Ana Edral ◽

Carolina Da Costa Gomes ◽

Rita Martins ◽

Ângela Ferreira

Keyword(s):

Abdominal Pain ◽

Pregnant Woman ◽

Early Intervention ◽

Cesarean Section ◽

Rare Complication ◽

Hypovolemic Shock ◽

Posterior Surface ◽

Spontaneous Hemoperitoneum ◽

Poor Outcomes ◽

In Pregnancy

Spontaneous hemoperitoneum in pregnancy is a rare complication resulting in high maternal and fetal morbidity and mortality. The authors describe the case of a pregnant woman presenting at 32 weeks of gestation with abdominal pain and free abdominal fluid on ultrasound. Laparotomy revealed a hemoperitoneum resulting from a suspected ruptured varices on the uterine posterior surface. A live newborn was delivered by cesarean-section, and hemorrhage was controlled with sutures and compression. Clinicians should be aware of this diagnosis when a pregnant woman presents with abdominal pain, anemia or hypovolemic shock. Early intervention will avoid poor outcomes for both the mother and the fetus.

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