The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal, South Africa: a randomized controlled trial

2001 ◽  
Vol 95 (2) ◽  
pp. 211-216 ◽  
Author(s):  
M. Taylor ◽  
C.C. Jinabhai ◽  
I. Couper ◽  
I. Kleinschmidt ◽  
V.B. Jogessar
Keyword(s):  
South Africa ◽  
Randomized Controlled Trial ◽  
Nutritional Status ◽  
Iron Supplementation ◽  
Controlled Trial ◽  
Anthelmintic Treatment ◽  
Treatment Regimens ◽  
Randomized Controlled ◽  
Kwazulu Natal

scholarly journals Effect of African leafy vegetables on the micronutrient status of mildly deficient farm-school children in South Africa: a randomized controlled study

2015 ◽  
Vol 19 (5) ◽  
pp. 935-945 ◽  
Author(s):  
Marinka van der Hoeven ◽  
Mieke Faber ◽  
Jennifer Osei ◽  
Annamarie Kruger ◽  
Cornelius M Smuts
Keyword(s):  
South Africa ◽  
Randomized Controlled Trial ◽  
Vitamin A ◽  
Serum Ferritin ◽  
Controlled Trial ◽  
Leafy Vegetables ◽  
Serum Retinol ◽  
School Meal ◽  
Randomized Controlled ◽  
Serum Zn

AbstractObjectiveA randomized controlled trial was conducted to assess the effect of African leafy vegetable (ALV) consumption on Fe, Zn and vitamin A status in children.DesignChildren were randomly allocated to receive either a 300 g cooked ALV dish and school meal starch (n86) or the normal school meal (n81) five times per week for three months. ALV in the dish consisted mainly ofAmaranthus cruentus(at least 80 %) and the remainder ofCleome gynandra,Cucurbita maximaorVigna unguiculata. Nutrient content and consumer acceptance of the ALV dish were also determined.SettingNorth West Province, South Africa.SubjectsGrade R to grade 4 children (6–12 years old) of two farm schools.ResultsThe ALV dish contributed 11·6–15·8 mg Fe and 1·4–3·7 mg Zn. At baseline, prevalence of deficiencies in the intervention group was 16·0 %, 16·3 %, 7·0 % and 75·6 %, respectively, for anaemia (Hb<11·5 g/dl), Fe (serum ferritin<15 µg/l), vitamin A (serum retinol<20 μg/dl) and Zn (serum Zn<65 μg/dl); and in the control group 10·5 %, 18·5 %, 2·5 % and 75·3 %, respectively. No significant estimated intervention effect was found.ConclusionsThis randomized controlled trial showed that ALV were unable to improve serum retinol, serum ferritin or Hb if there are only mild deficiencies present. Furthermore, despite the low Zn status in the study population, ALV consumption did not improve serum Zn concentrations either.

scholarly journals A Randomized Controlled Trial of Daily and Weekly Iron Supplementations for Improving Iron Status in the Infants

2021 ◽  
Author(s):  
Nalinee Pattrakornkul ◽  
Parichaya Ngamcherdtrakul ◽  
Warawut Kriangburapa ◽  
Siriporn Tangjaturonrasme ◽  
Ramorn Yampratoom
Keyword(s):  
Randomized Controlled Trial ◽  
Iron Deficiency ◽  
Iron Supplementation ◽  
Iron Status ◽  
Controlled Trial ◽  
Daily Group ◽  
Randomized Controlled ◽  
The Mean ◽  
Mean Differences ◽  
Weekly Group

Abstract Background: Iron deficiency anemia screening and iron supplementation in infants aged 6-12 months are recommended in the Guideline in Child Health Supervision. This study aims to evaluate the effectiveness of weekly iron supplementation compared with daily supplementation in improving the iron status in infants.Methods: A single-blind randomized controlled trial was conducted in infants aged 6 months visiting the Well Child Clinic between May 2019 and November 2020 at Burapha University Hospital, Chonburi, Thailand. The intervention consisted of either daily or weekly iron supplementation combined with iron-rich complementary food promotion for six months. The outcomes were the differences of serum ferritin and hematological variables before and after being iron supplemented. Results: Sixty-nine six-month-old healthy infants were randomized to receive either 10 mg Fe/day (daily group) or 30 mg Fe/week (weekly group). Forty-five infants (daily group; n = 24 and weekly group; n = 21) completed the intervention. After the six-month period of iron supplementation, the mean differences of serum ferritin in the daily and the weekly group were 8.78±37.21 and -13.05 ±17.53 ng/mL, respectively (95%CI: 4.54, 39.12; P=0.015). The mean differences of hemoglobin in the daily and the weekly group were 0.58±0.82 and 0.08±0.59 g/dL, respectively (95%CI: 0.06, 0.93; P=0.026). Daily supplementation could prevent iron deficiency more than weekly supplementation significantly (P=0.029), particularly in the exclusive breastfeeding subgroup (P=0.032).Conclusions: Daily iron supplementation is more effective than weekly iron supplementation in improving iron status and hemoglobin level in infants, especially in the exclusively breast-feds.Trial registration: TCTR20191107001, November 7th, 2019. Retrospectively registered, http://www.thaiclinicaltrials.org

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