Recent advances in the total synthesis of steroids via intramolecular cycloaddition reactions

Tetrahedron ◽  
1981 ◽  
Vol 37 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Tetsuji Kametani ◽  
Hideo Nemoto
Keyword(s):  
Total Synthesis ◽  
Cycloaddition Reactions ◽  
Intramolecular Cycloaddition ◽  
Recent Advances

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity

2021 ◽  
Author(s):  
Robert M. Hohlman ◽  
David H. Sherman
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Indole Alkaloids ◽  
Recent Advances

This review covers isolation, biological activity, an overview of total synthesis efforts and recent biosynthetic discoveries related to hapalindole-type indole alkaloids.

Intermolecular and intramolecular cycloaddition reactions of 1-ethyl-1,2,4-triazinium salts with alkynes

2001 ◽  
Vol 11 (1) ◽  
pp. 19-20 ◽  
Author(s):  
Nataliya N. Mochulskaya ◽  
Anatoly A. Andreiko ◽  
Valery N. Charushin ◽  
Boris V. Shulgin ◽  
Dmitry V. Raikov ◽  
...  
Keyword(s):  
Cycloaddition Reactions ◽  
Intramolecular Cycloaddition
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