Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study

2008 ◽  
Vol 2008 ◽  
pp. 296-298
Author(s):  
B.J. Gersh
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Statin Treatment ◽  
Case Control ◽  
Prevention Study ◽  
The West ◽  
Primary Prevention Study ◽  
Nested Case Control ◽  
Control Study

scholarly journals Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vera L. Costa ◽  
Jean-Bernard Ruidavets ◽  
Vanina Bongard ◽  
Bertrand Perret ◽  
Emanuela Repetto ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Small Rna ◽  
Case Control Study ◽  
Disease Incidence ◽  
Case Control ◽  
Male Population ◽  
General Male Population ◽  
Nested Case Control ◽  
Control Study

AbstractDuring the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart disease (CHD) compared to age-matched CHD-free individuals. The present study aimed to examine the predictive value of serum s-RNYs for CHD events in the general male population. Within the frame of nested-case–control study, the GENES study, we measured the absolute expression of a RNY-derived small RNA, the s-RNY1-5p, in the serum of individuals (without CHD at baseline) who encountered a CHD event within 12 years of follow-up (n = 30) (Cases) and compared them to individuals who remained event-free (Controls) (n = 30). The expression of s-RNY1-5p in serum was significantly upregulated in Cases compared to Controls (p = 0.027). The proportion of CHD event-free was significantly higher among individuals with serum s-RNY1-5p below the median value (631 molecules/mL). In a multivariable model adjusted for age, smoking, hypertension, diabetes and dyslipidemia, the risk of CHD events increased more than fourfold in individuals with serum s-RNY1-5p above the median value (HR, 4.36; 95% CI 1.22–15.60). A positive association with CHD events was also observed when considering s-RNY1-5p as a continuous variable (p = 0.022). Based on our results, we conclude that serum s-RNY1-5p is an independent predictor of CHD events in a general male population and might be a relevant biomarker for early detection of cardiovascular diseases.

scholarly journals Serum taurine and risk of coronary heart disease: a prospective, nested case–control study

2012 ◽  
Vol 52 (1) ◽  
pp. 169-178 ◽  
Author(s):  
Oktawia P. Wójcik ◽  
Karen L. Koenig ◽  
Anne Zeleniuch-Jacquotte ◽  
Camille Pearte ◽  
Max Costa ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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