The portuguese psychiatry in the european setting: Study of a hospital drug formulary in the beginning of the 20th century

2011 ◽  
Vol 26 (S2) ◽  
pp. 1237-1237
Author(s):  
J.R. Pita ◽  
A.L. Pereira ◽  
J.S. Ferreira ◽  
J. Morgado
Keyword(s):  
Drug Therapy ◽  
Mental Disease ◽  
Comparative Method ◽  
Psychiatric Medication ◽  
Drug Formulary ◽  
Medicinal Products ◽  
Specific Medication ◽  
Hospital Drug Formulary ◽  
History Of ◽  
In The Beginning

The results of an investigation conducted on the Formulario Especial dos Medicamentos para o Hospital de alienados em Rilhafoles (1901), a mental disease drug formulary for the oldest Portuguese psychiatric hospital, are presented. The study considered the Portuguese situation within the European setting.This study quantifies the number of drugs and pharmaceutical forms and establishes a comparison with the most commonly used international psychiatric medication at the time. The present study aims at contributing to the history of psychiatric drug therapy before the advent of psychoactive drugs. The most commonly used pharmaceutical forms and therapeutic groups in psychiatry are evaluated. Furthermore, we also wish to contribute to the evaluation of how Portugal received and implemented innovations in drug therapy.Quantitative and qualitative document analysis of the above mentioned formulary, using the comparative method.The edition of this formulary arose from the need to standardize specific medication for mental patients. In the Formulario, 61 medicinal products are proposed. There were 8 different pharmaceutical forms. The potions were the most commonly referred (32). Hypnotics represented approximately half of the medicinal products (28), followed by hypokinetics (9), and analgesics and antipyretics (8).The formulary was in line with foreign scientific innovations. Pharmacotherapeutic variety of drugs was short and resorting to non-drug therapies was also usual. The edition of this formulary was mainly due to the work conducted by the psychiatrist Miguel Bombarda (1851–1910), a prominent public figure in medicine and in the political and cultural arena.

Urokinase Antigen in Plasma of Patients with Liver Cirrhosis and Hepatoma

1985 ◽  
Vol 54 (03) ◽  
pp. 617-618 ◽  
Author(s):  
J C Kirchheimer ◽  
K Huber ◽  
P Polterauer ◽  
B R Binder
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Liver Function ◽  
Matched Control ◽  
Malignant Growth ◽  
Control Groups ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Specific Medication ◽  
History Of

SummaryPlasma urokinase antigen levels were studied in 78 patients suffering from liver diseases. Blood was drawn before any specific medication was initiated. Impairment of liver function was comparable in all patients. In both groups of cirrhotic liver disease (alcoholic and non-alcoholic), normal levels of plasma urokinase antigen were found as compared to age-matched control groups. In both groups of patients with hepatomas (with or without a history of liver cirrhosis), however, significantly increased plasma urokinase antigen levels could be determined. These data indicate that an increase in plasma urokinase antigen might rather relate to malignant growth in liver disease than to impaired liver function.

Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review

2020 ◽  
Author(s):  
Judd Sher ◽  
Kate Kirkham-Ali ◽  
Denny Luo ◽  
Catherine Miller ◽  
Dileep Sharma
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Drug Therapy ◽  
Dental Implant ◽  
Case Series ◽  
Cochrane Central Register ◽  
Bisphosphonate Treatment ◽  
Implant Placement ◽  
Increased Risk ◽  
History Of

The present systematic review evaluates the safety of placing dental implants in patients with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and OpenGrey databases were used to search for clinical studies (English only) to July 16, 2019. Study quality was assessed regarding randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases using a modified Newcastle-Ottawa scale and the Joanna Briggs Institute critical appraisal checklist for case series. A broad search strategy resulted in the identification of 7542 studies. There were 28 studies reporting on bisphosphonates (5 cohort, 6 case control, and 17 case series) and one study reporting on denosumab (case series) that met the inclusion criteria and were included in the qualitative synthesis. The quality assessment revealed an overall moderate quality of evidence among the studies. Results demonstrated that patients with a history of bisphosphonate treatment for osteoporosis are not at increased risk of implant failure in terms of osseointegration. However, all patients with a history of bisphosphonate treatment, whether taken orally for osteoporosis or intravenously for malignancy, appear to be at risk of ‘implant surgery-triggered’ MRONJ. In contrast, the risk of MRONJ in patients treated with denosumab for osteoporosis was found to be negligible. In conclusion, general and specialist dentists should exercise caution when planning dental implant therapy in patients with a history of bisphosphonate and denosumab drug therapy. Importantly, all patients with a history of bisphosphonates are at risk of MRONJ, necessitating this to be included in the informed consent obtained prior to implant placement. The James Cook University College of Medicine and Dentistry Honours program and the Australian Dental Research Foundation Colin Cormie Grant were the primary sources of funding for this systematic review.

From the History of the Public Library in the Village Tagai of Simbirsk District in Simbirsk Province

2010 ◽  
pp. 102-106
Author(s):  
Valentina M. Patutkina
Keyword(s):  
Public Library ◽  
Library History ◽  
The Public ◽  
Ulyanovsk Region ◽  
History Of ◽  
In The Beginning ◽  
The Village

The article is dedicated to unknown page in the library history of Ulyanovsk region. The author writes about the role of Trusteeship on people temperance in opening of libraries. The history of public library organized in the beginning of XX century in the Tagai village of Simbirsk district in Simbirsk province is renewed.

‘... Call the Mute Artifacts to Speech’: New Essays on the History of Archeology

2018 ◽  
pp. 1274-1279
Author(s):  
Elena V. Olimpieva ◽  
Keyword(s):  
20Th Century ◽  
Comparative Method ◽  
Early 20Th Century ◽  
Historical Overview ◽  
Historical Experience ◽  
Historical Material ◽  
Manuscript Tradition ◽  
History Of ◽  
Publication Practices ◽  
Controversial Nature

The article reviews O. A. Shashkova’s ‘... Call the Mute Artifacts to Speech.’ Essays on the History of Archaeography of the 15th - Early 20th Century. Wide array of sources and broad geographical frameworks allow Shashkova to present emergence and development of Russian and European archaeography from the 15th to early 20th century intelligibly enough for educational purposes. A whole chapter is devoted to the manuscript tradition and publishing of sources before Gutenberg. When considering the formation of archaeographical tradition, the author uses comparative method. O. A. Shashkova offers a historical overview and analyzes theoretical and practical issues of archaeography. The reviewer notes the significance of the chosen topic due to a need to reconsider the development of publishing in light of modern views on archaeography and to make it accessible to students and non-professionals. She notes traditional academic approach of O. A. Shashkova to presentation of the development publication practices. The review considers the possibility of using the ‘Essays...’ in studying the history of archaeography and offers possible directions for a broader consideration of historical experience, in particular, of Novikov’s publication projects. The review notes the controversial nature of the author’s approach to systematization of her large historical material in order to consider issues concerning the study of archaeographical practices. It stresses that coverage of issues of development of methods of preparation of publications separately from its historical and practical aspects hinders successful mastering of the material by an untrained reader. It concludes that the publication has high practical value for specialists in archaeography and students.

Writing and Ritual in Deuteronomy 28

2017 ◽  
Author(s):  
Laura Quick
Keyword(s):  
Ad Hoc ◽  
Comparative Method ◽  
Literary Texts ◽  
History Of ◽  
Important Means ◽  
Written Word ◽  
Ritual Process ◽  
Different Cultures ◽  
Ritual Context

This chapter argue that ritual behaviours might be just as good a source as literary texts for the diffusion of traditional cursing and treaty material across different cultures in the ancient Near East. In particular, the role of ad hoc oral Targum in the ritual process could have been an important means by which traditions were shared between different language communities. Recognition of the ritual context of this material also provides insights for the comparative method, the dating and authorship of Deuteronomy 28, and the subversive impetus thought to have stood behind its composition. Ultimately, the function of the written word in a largely oral world is shown to be fundamental to understanding the composition, function and the early history of the curses in the book of Deuteronomy.

scholarly journals When research met policy: a history of innovation and a complicated relationship in three Swedish development projects in mathematics education, 1960–2018

ZDM ◽  
2021 ◽  
Author(s):  
Johan Prytz
Keyword(s):  
Mathematics Education ◽  
Comparative Method ◽  
School Governance ◽  
Development Projects ◽  
Historical Sources ◽  
Major Development ◽  
History Of ◽  
Historical Comparative ◽  
The 1960S ◽  
Contemporary Development

AbstractThis paper concerns the relationship between research and governance policy in three Swedish major development projects in mathematics education: the New Math project (1960–1975), the PUMP project (1970–1980), and the Boost for Mathematics project in (2012–2016). All three projects were driven or financed by the Swedish central school authorities. Using a historical comparative method, this study deepens the understanding of how research co-exists with governance policy when preparing innovations in mathematics education. The main historical sources are official reports and governmental decisions concerning the three projects. The analysis is focused on the nature of the innovations of each project and the role of researchers in the process of creating the innovations. The analysis highlights the theories and the methods involved in those processes. The three projects are also positioned in a context of school governance policy. In Sweden, the prevailing school governing policy changed from a highly centralised governance in the 1960s to a highly decentralised governance in the 2010s. The paper concludes by discussing to what degree the researchers adhered to principles of research or school governance; in particular, the Boost for Mathematics project is considered in this regard. The relevance of the paper in relation to the emerging field of implementation research in mathematics education concerns how historical studies can give new insights about contemporary development projects in mathematics education.

scholarly journals Multicenter point prevalence evaluation of the utilization and safety of drug therapies for COVID-19 at the onset of the pandemic timeline in the United States

2021 ◽  
Author(s):  
Nathaniel J Rhodes ◽  
Atheer Dairem ◽  
William J Moore ◽  
Anooj Shah ◽  
Michael J Postelnick ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Drug Therapy ◽  
Supportive Care ◽  
The United States ◽  
Primary Objective ◽  
Point Prevalence ◽  
Medical Centers ◽  
Academic Medical ◽  
History Of ◽  
Secondary Objective

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose There are currently no FDA-approved medications for the treatment of coronavirus disease 2019 (COVID-19). At the onset of the pandemic, off-label medication use was supported by limited or no clinical data. We sought to characterize experimental COVID-19 therapies and identify safety signals during this period. Methods We conducted a non-interventional, multicenter, point prevalence study of patients hospitalized with suspected/confirmed COVID-19. Clinical and treatment characteristics within a 24-hour window were evaluated in a random sample of up to 30 patients per site. The primary objective was to describe COVID-19–targeted therapies. The secondary objective was to describe adverse drug reactions (ADRs). Results A total of 352 patients treated for COVID-19 at 15 US hospitals From April 18 to May 8, 2020, were included in the study. Most patients were treated at academic medical centers (53.4%) or community hospitals (42.6%). Sixty-seven patients (19%) were receiving drug therapy in addition to supportive care. Drug therapies used included hydroxychloroquine (69%), remdesivir (10%), and interleukin-6 antagonists (9%). Five patients (7.5%) were receiving combination therapy. The rate of use of COVID-19–directed drug therapy was higher in patients with vs patients without a history of asthma (14.9% vs 7%, P = 0.037) and in patients enrolled in clinical trials (26.9% vs 3.2%, P < 0.001). Among those receiving drug therapy, 8 patients (12%) experienced an ADR, and ADRs were recognized at a higher rate in patients enrolled in clinical trials (62.5% vs 22%; odds ratio, 5.9; P = 0.028). Conclusion While we observed high rates of supportive care for patients with COVID-19, we also found that ADRs were common among patients receiving drug therapy, including those enrolled in clinical trials. Comprehensive systems are needed to identify and mitigate ADRs associated with experimental COVID-19 treatments.

Nurses and Prescriptive Authority: A Legal and Economic Analysis

1989 ◽  
Vol 15 (2-3) ◽  
pp. 245-299 ◽  
Author(s):  
Elizabeth Harrison Hadley
Keyword(s):  
Health Care ◽  
Drug Therapy ◽  
Economic Efficiency ◽  
Health Care Professionals ◽  
Legal Authority ◽  
Economic Implications ◽  
Health Care Professions ◽  
Prescriptive Authority ◽  
Complementary Role ◽  
History Of

This article identifies twenty-six jurisdictions where nurses have been granted legal authority to prescribe drugs. The jurisdictions are divided into two groups: those where nurses have authority to prescribe without the supervision of a physician and can therefore function as substitutes for physicians; and those where nurses may prescribe only in collaboration with a supervising physician, and are thereby limited to functioning in a complementary role.The issue of prescriptive authority is discussed within the context of regulating the practice of nursing, and more generally, the health care professions. The article reviews the history of Nurse Practice Acts, focusing upon the Connecticut statute and the economic implications of this statutory approach. It is argued that the law should promote the use of nurses as substitutes for physicians whenever appropriate.The article concludes with a two-part proposal for reform: an “authorized prescriber” statute requiring health care professionals desiring to prescribe drugs to pass an examination testing their knowledge of pharmacology and drug therapy; and the elimination of the “unauthorized practice” provisions of the statutes regulating all health care professions. The proposal promotes economic efficiency by eliminating artificial constraints on the substitutability of labor in the provision of health services.

HISTORIOGRAPHY OF HISTORY OF THE STAVROPOL COSSACKS: KEY ASPECTS OF STUDYING THE REGIONAL COSSACK GROUP’S PAST

2021 ◽  
pp. 50-62
Author(s):  
K.A. Ushmaeva ◽  
◽  
A.S. Goncharov
Keyword(s):  
Comparative Method ◽  
Educational Institution ◽  
Practical Significance ◽  
Pedagogical Tools ◽  
Ideal Types ◽  
History Of ◽  
Historical Comparative ◽  
State Archives ◽  
Key Aspects ◽  
Economic Ties

This study is devoted to the study of relevant works on the history of the Stavropol Cossacks, works in the field of education of the Stavropol Cossacks as an independent Cossack group, trade, cultural and economic ties in the Stavropol Territory, spiritual life, language, culture, traditions and customs of the Stavropol Cossacks. Among modern studies in the history of the Stavropol Cossacks, the following topics stand out: military life and everyday life, folklore and song traditions, the movement for the revival of the Cossacks, as well as the current state and prospects for the development of Cossack organizations. The prospect of the development of pedagogical technologies based on the Cossack traditions of educating young people in Stavropol is highlighted as a separate topical topic. The relevance of the study lies in the need for a private study of the historiography of the regional Cossack group of Stavropol Cossacks in order to expand the scientific and pedagogical tools in the field of «Cossack studies». The practical significance of the study is expressed in the possibility of using the data of the article in the search for supporting material for teaching the "History of the Cossacks" in a higher educational institution (taking into account the regional specifics). The scientific novelty of the research is expressed in a new view of the Stavropol Cossacks as an independent Cossack group formed at the end of the XVIII century. The source base is represented mainly by archival data from the State Archives of the Stavropol Territory, data banks on archaeological, cultural and linguistic expeditions, sources of personal origin, the works of contemporary historians and directly the works of historians, whose studies formed the basis of the historiography of the history of the Stavropol Cossacks. The research methodology is based on the principles of historiographic comparative studies and comparative analysis of sources. Within the framework of the sociocultural approach, we rely on the following methods. Special-historical: the narrative method, the historical-comparative method, the historical-systemic method, the retrospective method. Sociological: document analysis, method of generalizing characteristics, method of ideal types. Culturological: comparative method, cultural-systemic method. Pedagogical: pedagogical interviewing, a method of studying and generalizing pedagogical experience.

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