P.2.f.015 Biomarkers of the rapid clinical response to ketamine in treatment-resistant depression: focus on kynurenine

2014 ◽  
Vol 24 ◽  
pp. S460
Author(s):  
G. Clarke ◽  
M. Naughton ◽  
R. O'Shea ◽  
J. Dowling ◽  
A. Walsh ◽  
...  
Keyword(s):  
Clinical Response ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

The priming effect of repetitive transcranial magnetic stimulation on clinical response to electroconvulsive therapy in treatment-resistant depression: a randomized, double-blind, sham-controlled study

2021 ◽  
pp. 1-12
Author(s):  
Maud Rothärmel ◽  
Pierre Quesada ◽  
Thomas Husson ◽  
Ghina Harika-Germaneau ◽  
Clément Nathou ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Clinical Response ◽  
Electroconvulsive Therapy ◽  
Magnetic Stimulation ◽  
Priming Effect ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Double Blind ◽  
Resistant Depression

Abstract Background Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression (TRD). However, due to response delay and cognitive impairment, ECT remains an imperfect treatment. Compared to ECT, repetitive transcranial magnetic stimulation (rTMS) is less effective at treating severe depression, but has the advantage of being quick, easy to use, and producing almost no side effects. In this study, our objective was to assess the priming effect of rTMS sessions before ECT on clinical response in patients with TRD. Methods In this multicenter, randomized, double-blind, sham-controlled trial, 56 patients with TRD were assigned to active or sham rTMS before ECT treatment. Five sessions of active/sham neuronavigated rTMS were administered over the left dorsolateral prefrontal cortex (20 Hz, 90% resting motor threshold, 20 2 s trains with 60-s intervals, 800 pulses/session) before ECT (which was active for all patients) started. Any relative improvements were then compared between both groups after five ECT sessions, in order to assess the early response to treatment. Results After ECT, the active rTMS group exhibited a significantly greater relative improvement than the sham group [43.4% (28.6%) v. 25.4% (17.2%)]. The responder rate in the active group was at least three times higher. Cognitive complaints, which were assessed using the Cognitive Failures Questionnaire, were higher in the sham rTMS group compared to the active rTMS group, but this difference was not corroborated by cognitive tests. Conclusions rTMS could be used to enhance the efficacy of ECT in patients with TRD. ClinicalTrials.gov: NCT02830399.

T121. Increased Resting State fMRI Entropy Associated With Clinical Response to Ketamine for Treatment Resistant Depression in Adolescents

2018 ◽  
Vol 83 (9) ◽  
pp. S175 ◽  
Author(s):  
Abhrajeet Roy ◽  
Bryon Mueller ◽  
Bonnie Klimes-Dougan ◽  
Mindy Schreiner ◽  
Michelle Thai ◽  
...  
Keyword(s):  
Clinical Response ◽  
Resting State ◽  
Resting State Fmri ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Sleep deprivation with sleep phase advance in treatment-resistant depression therapy in relation to features of circadian rhythm and temperament – a pilot study

2019 ◽  
Vol 34 (4) ◽  
pp. 249-262
Author(s):  
Ewa Kurczewska ◽  
Ewa Ferensztajn-Rochowiak ◽  
Maria Chłopocka-Woźniak ◽  
Janusz Rybakowski
Keyword(s):  
Sleep Deprivation ◽  
Clinical Response ◽  
Clinical Improvement ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Sleep Phase ◽  
Affective Temperaments ◽  
Severity Of Depression ◽  
Resistant Depression ◽  
The Relationship

Objectives. The efficacy of pharmacotherapy augmentation by total sleep deprivation (TSD) with sleep phase advance (SPA) was evaluated in patients with treatment-resistant depression (TRD). The study examined the relationship between chronotype, affective temperaments and clinical improvement resulting from the treatment. Material and methods. The study group comprised of 30 persons with treatment-resistant unipolar (n = 15) or bipolar (n = 15) depression aged 52 ± 12 years (17 women and 13 men). TSD and three consecutive nights with SPA were used during pharmacotherapy. Severity of depression was determined using the Hamilton Depression Rating Scale (HDRS). All patients were assessed using the Composite Scale of Morningness (CSM) and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A). Results. Clinical response, defined as a reduction in the severity of depression by ≥ 50% in HDRS compared to the baseline score, lasting until the end of the study (14 days), was obtained in 16 out of 30 patients with TRD. There was found no significant correlation between clinical improvement, chronotype and affective temperaments. Conclusions. TSD with SPA proved to be an effective method of pharmacotherapy augmentation in over half of the patients with TRD. The relationship between chronotype, affective temperaments and the clinical response to chronotherapy of depression requires further research.

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