A highly efficient synthesis of RWJ 47639: a novel orally active angiotensin II receptor antagonist.

1993 ◽  
Vol 3 (8) ◽  
pp. 1523-1526 ◽  
Author(s):  
Jeffrey D. Hsi ◽  
William V. Murray ◽  
Alan Gill
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Efficient Synthesis ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist ◽  
Highly Efficient ◽  
Orally Active

scholarly journals Losartan (DuP 753), An Orally Active Nonpeptide Angiotensin II Receptor Antagonist

1991 ◽  
Vol 9 (4) ◽  
pp. 317-339 ◽  
Author(s):  
Pancras C. Wong ◽  
T. Bradford Barnes ◽  
Andrew T. Chiu ◽  
David D. Christ ◽  
John V. Duncia ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist ◽  
Orally Active

scholarly journals Efficient and improved synthesis of Telmisartan

2010 ◽  
Vol 6 ◽  
Author(s):  
A Sanjeev Kumar ◽  
Samir Ghosh ◽  
G N Mehta
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Reductive Amination ◽  
Cross Coupling ◽  
Efficient Synthesis ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist

An efficient synthesis of the angiotensin II receptor antagonist Telmisartan (1) is presented involving a cross coupling of 4-formylphenylboronic acid 10 with 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline (11) as the key step (90% yield). The benzimidazole moiety 15 was constructed regioselectively via a reductive amination-condensation sequence, replacing the alkylation of the preformed benzimidazole step in the previously published route. This methodology overcomes many of drawbacks associated with previously reported syntheses.

ChemInform Abstract: Efficient Synthesis of Losartan, a Nonpeptide Angiotensin II Receptor Antagonist.

ChemInform ◽  
1995 ◽  
Vol 26 (16) ◽  
pp. no-no
Author(s):  
R. D. LARSEN ◽  
A. O. KING ◽  
C. Y. CHEN ◽  
E. G. CORLEY ◽  
B. S. FOSTER ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Efficient Synthesis ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist

1992 ◽  
Vol 12 (2) ◽  
pp. 149-191 ◽  
Author(s):  
John V. Duncia ◽  
David J. Carini ◽  
Andrew T. Chiu ◽  
Alexander L. Johnson ◽  
William A. Price ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist ◽  
Orally Active

Efficient Synthesis of Valsartan, a Nonpeptide Angiotensin II Receptor ­Antagonist

Synlett ◽  
2006 ◽  
Vol 2006 (03) ◽  
pp. 0475-0477 ◽  
Author(s):  
Yulin Li ◽  
Chen Zhang ◽  
Guojun Zheng ◽  
Lijing Fang
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Efficient Synthesis ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist

A Highly Potent, Orally Active Imidazo[4,5-b]pyridine Biphenyl Acylsulfonamide (MK-996; L-159,282): A New AT1-Selective Angiotensin II Receptor Antagonist

1994 ◽  
Vol 37 (24) ◽  
pp. 4068-4072 ◽  
Author(s):  
Prasun K. Chakravarty ◽  
Elizabeth M. Naylor ◽  
Anna Chen ◽  
Raymond S. L. Chang ◽  
Tsing-Bau Chen ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist ◽  
Orally Active
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