Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial

Jean-Pascal Machiels; Somasundaram Subramanian; Agnes Ruzsa; Gabor Repassy; Igor Lifirenko; Annika Flygare; Per Sørensen; Tina Nielsen; Steen Lisby; Paul MJ Clement

doi:10.1016/s1470-2045(11)70034-1

Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial

The Lancet Oncology ◽

10.1016/s1470-2045(11)70034-1 ◽

2011 ◽

Vol 12 (4) ◽

pp. 333-343 ◽

Cited By ~ 165

Author(s):

Jean-Pascal Machiels ◽

Somasundaram Subramanian ◽

Agnes Ruzsa ◽

Gabor Repassy ◽

Igor Lifirenko ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Supportive Care ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Best Supportive Care ◽

Open Label ◽

Phase 3 ◽

Platinum Based Chemotherapy ◽

Metastatic Squamous Cell Carcinoma

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Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial

The Lancet Oncology ◽

10.1016/s1470-2045(15)70124-5 ◽

2015 ◽

Vol 16 (5) ◽

pp. 583-594 ◽

Cited By ~ 239

Author(s):

Jean-Pascal H Machiels ◽

Robert I Haddad ◽

Jérôme Fayette ◽

Lisa F Licitra ◽

Makoto Tahara ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Line Treatment ◽

Second Line ◽

Open Label ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma ◽

Head Neck

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Faculty of 1000 evaluation for Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718018463.793480272 ◽

2013 ◽

Author(s):

Sandra Nuyts

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Randomised Trial ◽

Open Label ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma ◽

Open Label Phase

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Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial

The Lancet Oncology ◽

10.1016/s1470-2045(13)70181-5 ◽

2013 ◽

Vol 14 (8) ◽

pp. 697-710 ◽

Cited By ~ 301

Author(s):

Jan B Vermorken ◽

Jan Stöhlmacher-Williams ◽

Irina Davidenko ◽

Lisa Licitra ◽

Eric Winquist ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Randomised Trial ◽

Open Label ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma ◽

Open Label Phase

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Platinum‐based chemotherapy plus cetuximab first‐line for Asian patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: Results of an open‐label, single‐arm, multicenter trial

Head & Neck ◽

10.1002/hed.23707 ◽

2014 ◽

Vol 37 (8) ◽

pp. 1081-1087 ◽

Cited By ~ 16

Author(s):

Ye Guo ◽

Mei Shi ◽

Ankui Yang ◽

Jifeng Feng ◽

Xiaodong Zhu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Multicenter Trial ◽

First Line ◽

Open Label ◽

Asian Patients ◽

Platinum Based Chemotherapy ◽

Metastatic Squamous Cell Carcinoma

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Faculty Opinions recommendation of Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718018463.793481234 ◽

2013 ◽

Author(s):

Bruce Brockstein ◽

Nicholas Campbell

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Randomised Trial ◽

Open Label ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma ◽

Open Label Phase

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Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

The Lancet ◽

10.1016/s0140-6736(19)32591-7 ◽

2019 ◽

Vol 394 (10212) ◽

pp. 1915-1928 ◽

Cited By ~ 230

Author(s):

Barbara Burtness ◽

Kevin J Harrington ◽

Richard Greil ◽

Denis Soulières ◽

Makoto Tahara ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Open Label ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma ◽

Open Label Phase

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Nivolumab treatment beyond RECIST‐defined progression in recurrent or metastatic squamous cell carcinoma of the head and neck in CheckMate 141: A subgroup analysis of a randomized phase 3 clinical trial

Cancer ◽

10.1002/cncr.32190 ◽

2019 ◽

Vol 125 (18) ◽

pp. 3208-3218 ◽

Cited By ~ 24

Author(s):

Robert Haddad ◽

Fernando Concha‐Benavente ◽

George Blumenschein ◽

Jerome Fayette ◽

Joel Guigay ◽

...

Keyword(s):

Clinical Trial ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Subgroup Analysis ◽

Phase 3 ◽

Metastatic Squamous Cell Carcinoma

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Salvage chemotherapy versus best supportive care in patients with recurrent or metastatic squamous cell carcinoma of the esophagus refractory or intolerable to fluorouracil, platinum, and taxane.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.e15101 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. e15101-e15101

Author(s):

Takahiro Tsushima ◽

Motoo Nomura ◽

Satoru Iwasa ◽

Ken Kato ◽

Hirofumi Yasui ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Supportive Care ◽

Cell Carcinoma ◽

Squamous Cell ◽

Best Supportive Care ◽

Salvage Chemotherapy ◽

Carcinoma Of The Esophagus ◽

Metastatic Squamous Cell Carcinoma

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Phase I dose-finding and pharmacokinetic study of IV vinflunine in combination with methotrexate in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) previously treated with platinum-based chemotherapy.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.e17049 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. e17049-e17049

Author(s):

Audrey Mailliez ◽

Frederic Rolland ◽

Jean Marc Tourani ◽

Cedrik Lafond ◽

Didier Cupissol ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Phase I ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Pharmacokinetic Study ◽

Dose Finding ◽

Platinum Based Chemotherapy ◽

Metastatic Squamous Cell Carcinoma ◽

Previously Treated

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Active salvage chemotherapy versus best supportive care for patients with recurrent or metastatic squamous cell carcinoma of the esophagus refractory or intolerable to fluorouracil, platinum, and taxane

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-016-3179-3 ◽

2016 ◽

Vol 78 (6) ◽

pp. 1209-1216

Author(s):

Motoo Nomura ◽

Satoru Iwasa ◽

Takahiro Tsushima ◽

Ken Kato ◽

Hirofumi Yasui ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Supportive Care ◽

Cell Carcinoma ◽

Squamous Cell ◽

Best Supportive Care ◽

Salvage Chemotherapy ◽

Carcinoma Of The Esophagus ◽

Metastatic Squamous Cell Carcinoma

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