DISTRIBUTION OF ANDROGEN RECEPTORS IN SPINAL NEURONES INNERVATING THE SEMINAL VESICLE IN MALE RAT

2006 ◽  
Vol 5 (2) ◽  
pp. 63
Author(s):  
Q.S. Xue ◽  
C. Xu ◽  
E.D. Yaici ◽  
F. Giuliano ◽  
L. Cayzergues ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Androgen Receptors ◽  
Male Rat ◽  
Spinal Neurones

ZUM WIRKUNGSMECHANISMUS VON AN FETEN ANTIMASKULIN WIRKSAMEN GESTAGENEN

1964 ◽  
Vol 45 (4_Suppl) ◽  
pp. S139-S153 ◽  
Author(s):  
K. Junkmann ◽  
F. Neumann
Keyword(s):  
Pituitary Gland ◽  
Mechanism Of Action ◽  
Androgen Receptors ◽  
Male Rat ◽  
Pregnant Rats ◽  
Target Organs ◽  
Causative Factors ◽  
Competitive Action ◽  
Androgenic Effect

ABSTRACT Experiments are described dealing with the mechanism of action of 6-chloro-Δ6-1,2α-methylene-17α-hydroxyprogesterone-acetate with regard to its anti-masculine effect on male rat foetuses, when administered to pregnant rats. It was shown that a marked direct anti-androgenic effect due to a competitive action on androgen receptors within the target organs, is probably the explanation of the mechanism of action. It was further shown that an oestrogenic effect or an appreciable inhibition of the pituitary gland respectively, can be ruled out as causative factors in the mechanism of action.

Effects of prenatal X-irradiation on testicular function and morphology in the rat

1959 ◽  
Vol 196 (4) ◽  
pp. 896-898 ◽  
Author(s):  
Benjamin H. Ershoff
Keyword(s):  
Seminal Vesicle ◽  
Prenatal Development ◽  
Male Rat ◽  
Testicular Function ◽  
Seminal Vesicle Weight ◽  
X Irradiation ◽  
Testicular Injury

Present findings confirm and extend previous observations that x-irradiation during certain stages of prenatal development results in testicular injury and infertility in the male rat. The effects were particularly marked in the offspring of rats irradiated on the 18th day of pregnancy. These rats also showed in addition to testes injury a significant reduction in seminal vesicle weight. Testicular injury also occurred in the offspring of rats irradiated on the 14th day of pregnancy but was less marked than in the 18-day series. No abnormalities in testicular function or morphology were observed in the offspring of rats irradiated on the 10th day of pregnancy.

I. ANTI-ANDROGENIC EFFECTS OF A NEW STEROID TSAA-291 (16β-ETHYL-17β-HYDROXY-4-OESTREN-3-ONE) AND ITS DERIVATIVES

1979 ◽  
Vol 92 (3_Supplb) ◽  
pp. S2-S23 ◽  
Author(s):  
Ryo Nakayama ◽  
Michio Masuoka ◽  
Tsuneo Masaki ◽  
Kiro Shimamoto
Keyword(s):  
Seminal Vesicle ◽  
Dose Range ◽  
Seminal Vesicles ◽  
Male Rat ◽  
Lateral Side ◽  
Levator Ani Muscle ◽  
Response Curves ◽  
Left Testis ◽  
Muscle Weight ◽  
Adult Rat

ABSTRACT Anti-androgenic properties of newly synthesized steroidal compounds, TSAA-291* and its derivatives, were studied in the rat. (1) Subcutaneous administrations of TSAA-291 and TSAA-272* were effective in depressing the weight of seminal vesicles and ventral and dorsal prostates in the adult rat. (2) TSAA-291, TSAA-328* and TSAA-272 were shown to be anti-androgenic by the subcutaneous or oral route in the immature castrated male rat treated with testosterone propionate. The dose-response curves of all the test agents expressed in terms of percentage inhibition were approximately parallel to each other. Cyproterone acetate depressed the weight of levator ani muscle dose-dependently, whereas TSAA-291, TSAA-328 and TSAA-330* did not inhibit the muscle weight in a dose range sufficiently effective in inhibiting the weight of seminal vesicles and ventral and dorsal prostates. (3) TSAA-291 was also antiandrogenic against androstenedione and dehydroepiandrosterone. (4) Local administration of the anti-androgenic compounds into the left seminal vesicle or left testis of the young adult rat depressed the weight of the seminal vesicle or testis on the treated side as compared with the vehicle-injected contra-lateral side.

scholarly journals Studies on the metabolic role of myo-inositol. Distribution of radioactive myo-inositol in the male rat

1976 ◽  
Vol 156 (2) ◽  
pp. 375-380 ◽  
Author(s):  
L M Lewin ◽  
Y Yannai ◽  
S Sulimovici ◽  
P F Kraicer
Keyword(s):  
Seminal Vesicle ◽  
Trichloroacetic Acid ◽  
Lipid Fraction ◽  
Prostate Gland ◽  
Radioactive Material ◽  
Male Rat ◽  
Metabolic Role ◽  
Muscle Tissues ◽  
Coagulating Gland

Radioactive myo-inositol was injected intraperitoneally into nephrectomized rats. The radioactive material present in liver, spleen, brain, heart, diaphragm, seminal vesicle, coagulating gland, prostate, epididymis, vas deferens and testis was shown to consist exclusively of myo-inositol and its derivatives, as shown by paper chromatography of hydrolysates and trichloroacetic acid extracts of these tissues. Radioactive myo-inositol was accumulated rapidly within 1 h by the thyroid, coagulating gland and seminal vesicle. Other tissues, such as the pituitary, prostate gland, liver and spleen, concentrated myo-inositol less actively. The muscle tissues studied (diaphragm and heart) concentrated little inositol, whereas brain, testis, and epididymal fat-pad did not concentrate it at all. The lipid fraction of liver contained most of the radio-labelled myo-inositol. In the other organs most of the radioactivity was found in the aqueous trichloroacetic acid extract, largely as free myo-inositol.

Androgen receptors in Purkinje neurons are modulated by systemic testosterone and sexual training in a region-specific manner in the male rat

2016 ◽  
Vol 156 ◽  
pp. 191-198 ◽  
Author(s):  
Miguel Perez-Pouchoulen ◽  
Rebeca Toledo ◽  
Luis I. Garcia ◽  
Cesar A. Perez-Estudillo ◽  
Genaro A. Coria-Avila ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Purkinje Neurons ◽  
Male Rat ◽  
Specific Manner

Androgen Receptors and Estrogen Receptors Are Colocalized in Male Rat Hypothalamic and Limbic Neurons that Express Fos Immunoreactivity Induced by Mating

1998 ◽  
Vol 67 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Béatrice Gréco ◽  
David A. Edwards ◽  
Richard P. Michael ◽  
Andrew N. Clancy
Keyword(s):  
Estrogen Receptors ◽  
Androgen Receptors ◽  
Male Rat

scholarly journals Localization of metallothionein in the genital organs of the male rat.

1990 ◽  
Vol 38 (7) ◽  
pp. 927-933 ◽  
Author(s):  
H Nishimura ◽  
N Nishimura ◽  
C Tohyama
Keyword(s):  
Seminal Vesicle ◽  
Metal Binding ◽  
Close Association ◽  
Ejaculatory Duct ◽  
Lateral Lobe ◽  
Male Rat ◽  
Seminiferous Tubules ◽  
Complex Method ◽  
Basal Cells ◽  
Growing Rat

We studied the immunohistological localization of metallothionein (MT), a low molecular weight metal binding protein, in male rat genital organs (testis, epididymis, ejaculatory duct, seminal vesicle, coagulating gland, and prostate) by use of the avidin-biotin-peroxidase complex method. MT concentrations in testis, seminal vesicle, and prostate ranged from 15-30 micrograms/g tissue. In testis, seminiferous tubules with mature spermatozoa exhibited weak MT staining, whereas the tubules containing differentiating spermatogenic cells but not containing spermatozoa showed strong MT staining. No MT immunostaining was observed in Leydig cells. In growing rat testes, the pattern of MT immunostaining was found to change with development: MT was found in supporting cells only on Day 7, spermatogonia adjacent to basement membrane on Day 14, and spermatocytes localized in the central part of the tubules on Day 21. Strong MT immunostaining in the basal cells was a common feature in other genital tissues, except the ductus efferentes. In prostate, the strongest MT staining was found in the lateral lobe, and MT was localized in apocrine secretions in the dorsal lobe. The present results suggest a close association of MT with cell proliferation and differentiation, as well as possible involvement of MT in supply or storage of zinc ions.

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