Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)

Piotr Brański; Jakub Staroń; Ryszard Bugno; Joanna Wierońska; Andrzej Bojarski; Agnieszka Pałucha-Poniewiera; Andrzej Pilc; Grzegorz Burnat

doi:10.1016/s1734-1140(11)70547-3

Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)

Pharmacological Reports ◽

10.1016/s1734-1140(11)70547-3 ◽

2011 ◽

Vol 63 (2) ◽

pp. 577

Author(s):

Piotr Brański ◽

Jakub Staroń ◽

Ryszard Bugno ◽

Joanna Wierońska ◽

Andrzej Bojarski ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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Discovery, Synthesis, and Structure–Activity Relationship Development of a Series ofN-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model

Journal of Medicinal Chemistry ◽

10.1021/jm200956q ◽

2011 ◽

Vol 54 (21) ◽

pp. 7639-7647 ◽

Cited By ~ 40

Author(s):

Carrie K. Jones ◽

Darren W. Engers ◽

Analisa D. Thompson ◽

Julie R. Field ◽

Anna L. Blobaum ◽

...

Keyword(s):

Animal Model ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Relationship Development ◽

Activity Relationship ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate ◽

Structure Activity

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Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.114.214437 ◽

2014 ◽

Vol 350 (3) ◽

pp. 495-505 ◽

Cited By ~ 43

Author(s):

Mikhail Kalinichev ◽

Emmanuel Le Poul ◽

Christelle Boléa ◽

Françoise Girard ◽

Brice Campo ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Neuropsychiatric Disorders ◽

Allosteric Modulator ◽

The Novel ◽

Rodent Models ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys

Biological Psychiatry ◽

10.1016/j.biopsych.2015.01.014 ◽

2015 ◽

Vol 78 (7) ◽

pp. 452-462 ◽

Cited By ~ 32

Author(s):

Zuzana Justinova ◽

Leigh V. Panlilio ◽

Maria E. Secci ◽

Godfrey H. Redhi ◽

Charles W. Schindler ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Squirrel Monkeys ◽

Allosteric Modulator ◽

The Novel ◽

Self Administration ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

Molecular Pharmacology ◽

10.1124/mol.112.083949 ◽

2013 ◽

Vol 83 (5) ◽

pp. 991-1006 ◽

Cited By ~ 60

Author(s):

Karen J. Gregory ◽

Elizabeth D. Nguyen ◽

Sean D. Reiff ◽

Emma F. Squire ◽

Shaun R. Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Point Mutations ◽

Binding Pocket ◽

Molecular Switch ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Molecular Pharmacology ◽

10.1124/mol.107.035170 ◽

2007 ◽

Vol 72 (2) ◽

pp. 477-484 ◽

Cited By ~ 116

Author(s):

Michael A. Benneyworth ◽

Zixiu Xiang ◽

Randy L. Smith ◽

Efrain E. Garcia ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate ◽

Hallucinogenic Drug

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Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia

Neuropharmacology ◽

10.1016/j.neuropharm.2012.03.022 ◽

2013 ◽

Vol 66 ◽

pp. 158-169 ◽

Cited By ~ 63

Author(s):

Khaled-Ezaheir Bennouar ◽

Michelle A. Uberti ◽

Christophe Melon ◽

Maria D. Bacolod ◽

Hermogenes N. Jimenez ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Disease Treatment ◽

Metabotropic Glutamate

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Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.102046 ◽

2006 ◽

Vol 318 (1) ◽

pp. 173-185 ◽

Cited By ~ 124

Author(s):

Ruggero Galici ◽

Carrie K. Jones ◽

Kamondanai Hemstapat ◽

Yi Nong ◽

Nicholas G. Echemendia ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.136580 ◽

2008 ◽

Vol 327 (3) ◽

pp. 827-839 ◽

Cited By ~ 138

Author(s):

Feng Liu ◽

Steve Grauer ◽

Cody Kelley ◽

Rachel Navarra ◽

Radka Graf ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats

Journal of Medicinal Chemistry ◽

10.1021/jm1012165 ◽

2011 ◽

Vol 54 (1) ◽

pp. 342-353 ◽

Cited By ~ 34

Author(s):

Raveendra-Panickar Dhanya ◽

Shyama Sidique ◽

Douglas J. Sheffler ◽

Hilary Highfield Nickols ◽

Ananda Herath ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Self Administration ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate ◽

Design And Synthesis ◽

Orally Active

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Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.07.072 ◽

2009 ◽

Vol 19 (17) ◽

pp. 4967-4970 ◽

Cited By ~ 25

Author(s):

Richard Williams ◽

Kari A. Johnson ◽

Patrick R. Gentry ◽

Colleen M. Niswender ◽

Charles D. Weaver ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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