Impact of Clostridioides difficile infection on patient-reported quality of life

Abstract Objective: We investigated the quality of life (QoL) of patients hospitalized with C. difficile infection (CDI). Design: Prospective survey study. Setting: US tertiary-care referral center, acute-care setting. Participants: Adults hospitalized with a diagnosis of CDI, defined as ≥3 episodes of unformed stool in 24 hours and a positive laboratory test for C. difficile. Methods: We surveyed patients from July 2019 to March 2020 using the disease-specific Cdiff32 questionnaire and the generic PROMIS GH survey. We compared differences in Cdiff32 scores among demographic and clinical subgroups (including CDI severity, CDI recurrence, and various comorbidities) using 2-sample t tests. We compared PROMIS GH scores to the general population T score of 50 using 1-sample t tests. We performed multivariable linear regression to identify predictors of Cdiff32 scores. Results: In total, 100 inpatients (mean age, 58.6 ±17.1 years; 53.0% male; 87.0% white) diagnosed with CDI completed QoL surveys. PROMIS GH physical health summary scores (T = 37.3; P < .001) and mental health summary scores (T = 43.4; P < .001) were significantly lower than those of the general population. In bivariate analysis, recurrent CDI, severe CDI, and number of stools were associated with lower Cdiff32 scores. In multivariable linear regression, recurrent CDI, severe CDI, and each additional stool in the previous 24 hours were associated with significantly decreased Cdiff32 scores. Conclusions: Patients hospitalized with CDI reported low scores on the Cdiff32 and PROMIS GH, demonstrating a negative impact of CDI on QoL in multiple health domains. The Cdiff32 questionnaire is particularly sensitive to QoL changes in patients with recurrent or severe disease.

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Does Social Distancing During The Lock Down Due To Covid-19 Outbreak In Mumbai Affect Quality Of Life?

International Journal of Clinical and Biomedical Research ◽

10.31878/ijcbr.2020.62.01 ◽

2020 ◽

pp. 1-4

Author(s):

Hitav Someshwar ◽

Prachi Sarvaiya ◽

Swara Desai ◽

Priya Gogri ◽

Janvi Someshwar ◽

...

Keyword(s):

Quality Of Life ◽

General Population ◽

Negative Impact ◽

Demographic Data ◽

Survey Study ◽

Age Difference ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Social Distancing

Background – Social distancing leads to decrease in the spread of the novel virus but at the same time it shows to have a negative effect on the quality of life of the general population. Methodology - A cross-sectional survey study was conducted using an electronic version of WHOQOL-BREF scale. The demographic data was collected along with the 26 questions of the scale. We distributed this survey to the general population through electronic and social media. Results – We received 861 responses. Excluding the incomplete responses, we analyzed 832 responses. They had a mean age of 48.33yrs, majority being graduates (56.4%), majority of the subjects were males (59.25%), and there was no significant age difference between both the genders. The overall quality of life was perceived to be 3.48 and the satisfaction for health was 3.77. Most affected domains were the physical and psychological domains. Lowest quality of life responses were noted for questions pertaining to financial, transportation and sleep related. Conclusion- The quality of life in lock downs due to corona virus is affected due to social distancing. Law makers need to take care to avoid increasing this negative impact while enforcing lock downs.

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A139 IMPROVED QUALITY OF LIFE AFTER ENDOSCOPIC THERAPY FOR BARRETT’S ESOPHAGUS AND EARLY ESOPHAGEAL CANCER IN SOUTHERN ALBERTA

Journal of the Canadian Association of Gastroenterology ◽

10.1093/jcag/gwab002.137 ◽

2021 ◽

Vol 4 (Supplement_1) ◽

pp. 125-126

Author(s):

T Jeyalingam ◽

M Woo ◽

S E Congly ◽

J David ◽

P J Belletrutti ◽

...

Keyword(s):

Quality Of Life ◽

Linear Regression ◽

Multiple Linear Regression ◽

Barrett’S Esophagus ◽

Barrett's Esophagus ◽

Endoscopic Therapy ◽

Negative Impact ◽

Older Age ◽

The Impact

Abstract Background In patients with Barrett’s esophagus (BE), endoscopic therapy reduces the risk of progression to invasive esophageal adenocarcinoma (EAC). Data on the impact of endoscopic therapy on patient quality of life (QoL) is limited. Aims We aimed to assess: (1) change in QoL during the course of endoscopic therapy for BE, (2) factors which predict this change, (3) whether achieving complete remission of dysplasia (CRD) or intestinal metaplasia (CRIM) affect the degree of change. Methods We conducted a retrospective observational study using a prospectively maintained database of BE patients treated in Calgary, Alberta from 2013–2020 containing data on demographics, BE disease characteristics and therapeutics, QoL, and follow-up. QoL was determined prior to initiation of therapy and after each treatment session using a validated questionnaire. Descriptive statistics were calculated and change in QoL was compared using a Wilcoxon signed ranks test. Backwards multiple linear regression analysis was performed to determine predictors of change in QoL. Results Of 130 BE patients, 112 (86.1%) were male and 104 (80%) had dysplastic histology or intramucosal carcinoma on index endoscopy. Mean (SD) age was 65.6 (12.0) years. At time of analysis, 76 patients (58.5%) had completed endoscopic therapy, of whom 69 (90.8%) achieved CRIM; 54 patients (41.5%) were still undergoing treatment. There was significant improvement in all QoL measures during the treatment course except for “depression” (Table 1). Patients with CRIM or CRD had reductions in “sleep difficulty” and “negative impact on life” to a significantly greater degree vs patients not achieving CRIM (Δ sleep -0.45 vs 0.0, P=0.002; Δ negative impact -0.4 vs -0.05, P=0.014) or CRD (Δ sleep -0.40 vs +0.60, P=0.002; Δ negative impact -0.40 vs +0.20, P=0.04). Multiple linear regression revealed older age (B=-0.03, P=0.008) and fewer number of EMR sessions (B=0.254, P=0.008) were correlated with greater improvement in QoL. Conclusions Endoscopic therapy improves QoL in BE patients, especially in those achieving CRIM/CRD. Older age and fewer EMRs are correlated with greater improvement in QoL. These results further reinforce the role of endoscopic therapy as the first line treatment of BE and early EAC. Funding Agencies None

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Malocclusion and oral health-related quality of life in Brazilian school children

The Angle Orthodontist ◽

10.2319/010912-20.1 ◽

2012 ◽

Vol 83 (1) ◽

pp. 83-89 ◽

Cited By ~ 44

Author(s):

Fernanda Sardenberg ◽

Milene T. Martins ◽

Cristiane B. Bendo ◽

Isabela A. Pordeus ◽

Saul M. Paiva ◽

...

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Negative Impact ◽

Anterior Segment ◽

Bivariate Analysis ◽

Fisher Exact Test ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Objective: To test the hypothesis that malocclusion and its impact on quality of life has no effect on 8- to 10-year-old Brazilian schoolchildren as measured by an oral health-related quality of life (OHRQoL) instrument. Materials and Methods: A cross-sectional study was carried out with a population-based sample of 1204 8- to 10-year-old children attending elementary schools in Belo Horizonte, Brazil. Dental examinations were carried out by two calibrated examiners. OHRQoL was assessed using the Brazilian version of the Child Perceptions Questionnaire. The Dental Aesthetic Index was used for the clinical assessment of malocclusion. Dental caries and socioeconomic factors were used as controlling variables. Bivariate analysis involved the chi-square test and the Fisher exact test. A Poisson regression model was employed for the multivariate analysis (P < .05). Results: Anterior segment spacing and anterior mandibular overjet were significantly associated with impact on OHRQoL (P < .05). Schoolchildren with malocclusion were 1.30-fold (95% CI: 1.15–1.46; P < 0.001) more likely to experience a negative impact on OHRQoL than those without malocclusion. Children belonging to families with an income less than or equal to two times the minimum wage were 1.59-fold (95% CI: 1.35–1.88; P < 0.001) more likely to experience a negative impact on OHRQoL than those belonging to families with the highest income. Conclusions: Schoolchildren with malocclusion from lower-income families experience a greater negative impact on OHRQoL.

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A Novel Electronic Application of Patient-reported Outcomes in Multiple Sclerosis – Meeting the Necessary Challenge of Assessing Quality of Life and Outcomes in Daily Clinical Practice

European Neurological Review ◽

10.17925/enr.2014.09.01.49 ◽

2014 ◽

Vol 9 (1) ◽

pp. 49 ◽

Cited By ~ 3

Author(s):

Simon Exell ◽

Mark Thristan ◽

Fernando Dangond ◽

Kurt Marhardt ◽

Meaghan St Charles Krohe ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Clinical Practice ◽

Negative Impact ◽

Patient Reported Outcome ◽

Software Application ◽

Wireless Data Transmission ◽

Patient Reported ◽

Auto Injector

Multiple sclerosis (MS) has a substantial negative impact on health-related quality of life. Clinical assessments often do not include standardised, routine assessment of MS impact from the patient perspective, and communication between healthcare practitioners (HCPs) and patients can be lacking. Thus, there is a need for patient-reported outcome (PRO) measures to encourage patient–HCP communication, to help inform HCPs of matters important to patients and to aid both patients and HCPs in managing the disease. MSdialog is a web- and mobile-based software application that works with auto-injector devices and electronic autoinjectors, including the RebiSmart® 2.0 device (a handheld electronic Rebif® auto-injector with wireless data transmission capabilities, CE marked and available worldwide [excluding the US]) to collect and store real-time, point-of-administration adherence, clinician-reported outcomes and PRO data. MSdialog may provide a practical solution to support patient-proactive engagements and self-management, patient-centred care and participatory decision-making in clinical practice.

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Adult CHD patients under clinical follow-up have a similar quality of life to the general population in Malta

Cardiology in the Young ◽

10.1017/s1047951116001980 ◽

2016 ◽

Vol 27 (6) ◽

pp. 1051-1059

Author(s):

Maryanne Caruana ◽

Victor Grech

Keyword(s):

Quality Of Life ◽

Mental Health ◽

General Population ◽

Negative Impact ◽

Adult Survivors ◽

Cardiac Medication ◽

Self Reporting Questionnaire ◽

The Impact

AbstractBackgroundThe improved survival of patients born with CHD has led to increasing interest in research on quality of life of adult survivors. We report the findings of the first study in Malta carried out to investigate quality of life in adults with CHD under follow-up.MethodsA self-reporting questionnaire modelled on the basis of the European Health Interview Survey 2008, including questions on mental health and vitality, was administered to consecutive adult CHD outpatients, aged 16 years and over, between May, 2013 and May, 2014. Foreigners and patients with learning difficulties or cognitive impairment were excluded. Quality-of-life data were compared with that from 371 age- and sex-matched 2008 survey responders – general population cohort. The impact of congenital lesion complexity, hospitalisation in the preceding 12 months, arrhythmias, co-morbidities, and cardiac medication use on quality of life of the CHD cohort was also investigated.ResultsThere were a total of 120 patient responders (63 males; mean age 30.53, SD 12.77 years). Overall, there were no significant differences in mental health and vitality between patient and general population cohorts, although older patients had better mental health scores compared with age-matched controls. Within the adult CHD cohort, hospitalisation in the preceding 12 months was the only factor associated with a poorer quality of life.ConclusionsOverall, CHD has no negative impact on mental health and vitality in Maltese adult patients under follow-up. Patients needing frequent hospitalisations might warrant closer attention by clinical psychologists.

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Association between Disease-Specific Quality of Life and Complementary Medicine Use in Patients with Rhinitis in Taiwan: A Cross-Sectional Survey Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/958524 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Malcolm Koo ◽

Kai-Li Liang ◽

Rong-San Jiang ◽

Hsin Tsao ◽

Yueh-Chiao Yeh

Keyword(s):

Quality Of Life ◽

Linear Regression ◽

Medical Condition ◽

Survey Study ◽

Regression Analyses ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Female Sex ◽

Disease Specific

Rhinitis is a common medical condition and can seriously impact patients’ quality of life. The objective of this study was to investigate the association between disease-specific quality of life and use of complementary and alternative medicine (CAM) modalities among Taiwanese rhinitis patients. A cross-sectional survey was undertaken at the outpatient department of otolaryngology in a medical center in Taiwan. Sociodemographic information, disease-specific quality of life (Chinese version of the 31-item Rhinosinusitis Outcome Measure, CRSOM-31), and previous use of CAM modalities for treatment of rhinitis of the patients were ascertained. Factor analysis was performed to reduce the number of CAM modalities. The resulting factors were analyzed for their association with CRSOM-31 score using linear regression analyses. Results from the multiple linear regression analyses indicated that Factor 1 (traditional Chinese medicine), Factor 2 (mind-body modalities), Factor 3 (manipulative-based modalities), female sex, and smoking were significantly associated with a worse disease-specific quality of life. In conclusion, various CAM modalities, female sex, and smoking were independent predictors of a worse disease-specific quality of life in Taiwanese patients with rhinitis.

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Patient Reported Outcome Measure in Atopic Dermatitis Patients Treated with Dupilumab: 52-Weeks Results

10.20944/preprints202105.0596.v1 ◽

2021 ◽

Author(s):

Servando E. Marron ◽

Lucia Tomas-Aragones ◽

Carlos A. Moncin-Torres ◽

Manuel Gomez-Barrera ◽

Francisco Javier Garcia-Latasa de Aranibar

Keyword(s):

Quality Of Life ◽

Atopic Dermatitis ◽

Clinical Practice ◽

Stressful Life Events ◽

Severe Disease ◽

Patient Reported Outcome ◽

Routine Clinical Practice ◽

Severe Atopic Dermatitis ◽

Patient Reported

Dupilumab is used to treat atopic dermatitis patients who have proven to be refractory to previous treatments. The aim of this study was to assess evolution and patient reported outcome measures in adult patients with moderate-to-severe atopic dermatitis treated with Dupilumab in routine clinical practice. The outcomes were evaluated and registered at baseline and weeks-16, 40 and 52. The variables evaluated were: diseases severity, pruritus, stressful life events, difficulty to sleep, anxiety and depression, quality of life, satisfaction, adherence to the treatment, efficacy and safety. Eleven patients were recruited between Nov 14th 2017 and Jan 16th 2018. Demographic variables: 90% Caucasian, 82% women. Clinical variables: Mean duration of AD =17.7 (±12.8), 91% had severe disease severity. At baseline, SCORAD mean score = 61.7 (±15.5); itch was reported by 100% of patients; itch Visual Analogue Scale mean range of 8 (6-10); HADS mean total score =13.9 (±5.5); DLQI mean score =13.3 (±8.3): EQ-5D-3L mean range = 57 (30-99). At week-52 there is a significant reduction of SCORAD scores, HADS total score and improved quality of life. ¡This study confirms that Dupilumab, used for 52-weeks under routine clinical practice, maintains the improved atopic dermatitis signs and symptoms obtained at week-16, with a good safety profile.

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Dermatological life quality index in psoriasis

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20194673 ◽

2019 ◽

Vol 5 (4) ◽

pp. 812

Author(s):

N. R. Vignesh ◽

Jayakar Thomas

Keyword(s):

Quality Of Life ◽

Quality Index ◽

Tertiary Care ◽

Life Quality ◽

Inflammatory Disorder ◽

Scalp Psoriasis ◽

Patient Reported ◽

Significant Impairment ◽

Life Quality Index

Background: Psoriasis is an immune mediated chronic inflammatory disorder characterized by chronicity of the condition and periods of relapses and remissions. Dermatological life quality index (DLQI) is a widely used measure to determine the patient reported outcome in psoriasis. This study was conducted to evaluate the quality of life in psoriasis patients depending upon their age, sex, type of the disease, duration of the disease and with treatment.Methods: This is a cross sectional study performed in a tertiary care center in Chennai. The study was performed in 100 patients with a prepared DLQI questionnaire. The patients were asked to fill in the questionnaire and the results were graded from mild to very severe.Results: In this study, males outnumbered women in the ratio of 1.2:1. Patients in the age group 41-60 years formed the majority in this study. Itching and soreness of the lesions worsened the DLQI in majority of the patients. Quality of life of patients with psoriasis vulgaris was much affected when compared with other types of psoriasis like erythrodermic and scalp psoriasis. Also, married patients with psoriasis had significant impairment in their quality of life compared to unmarried patients.Conclusions: The findings of this study showed that psoriasis has a significant impairment in the quality of life and hence DLQI should be assessed at the first visit and also after treatment to improve the compliance of the patients towards the doctor as well as to the treatment.

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Self-Perceived Impact of Oral Health on the Quality of Life of Women Deprived of Their Liberty

International Journal of Dentistry ◽

10.1155/2021/5520652 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Ludmila Roberto Moraes ◽

Lidiane Castro Duarte de Aquino ◽

Danielle Teles da Cruz ◽

Isabel Cristina Gonçalves Leite

Keyword(s):

Quality Of Life ◽

Oral Health ◽

General Health ◽

Dental Treatment ◽

Negative Impact ◽

Health Impact ◽

Bivariate Analysis ◽

Physical Pain ◽

Perceived Impact

Background. Prison units are marked by structural deficiencies, especially in relation to the female gender. Objectives. To measure the self-perceived impact of oral health on the quality of life of Brazilian women in detention. Methodology. A survey was carried out conducted in the penitentiary at Juiz de Fora (Minas Gerais, Brazil) using an instrument with semistructured questions and validated scales, including the Oral Health Impact Profile-14. 99 women were interviewed. The analysis was based on a theoretical model of determination, with hierarchical blocks of variables. Bivariate analysis was done using the Mann–Whitney, test and multivariate analysis was used using linear regression. The significance level was set at 5%. Results. 33% experienced tooth loss after incarceration, (3.70 ± 3.26 lost teeth). 65.6% rated the dental service as fair/poor. The highest prevalence of oral health impact was for the domains of psychological discomfort (50.5%) and physical pain (40.4%). There is a negative impact on psychological discomfort: the number of dental consultations in the past year and self-perceived general health. There is an impact on physical pain: self-declared color and anxiety. Self-perceived general health had an impact on the domains of psychological disability and social disadvantage. Depression had an impact on the total score. Conclusion. This study revealed a self-perceived impact of oral health on the quality of life of women inmates. We need to ensure high-quality access to dental treatment in prisons.

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TANGO: effect of tango Argentino on cancer-associated fatigue in breast cancer patients—study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-021-05869-3 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Shiao Li Oei ◽

Thomas Rieser ◽

Sarah Becker ◽

Jessica Groß ◽

Harald Matthes ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Sleep Quality ◽

Cancer Patients ◽

Negative Impact ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Argentine Tango ◽

Patient Reported

Abstract Background The majority of breast cancer patients suffer from persistent impairments after completion of their primary oncological therapy. Cancer-related fatigue (CRF) in particular is a multidimensional syndrome having a profound negative impact on the quality of life. To counter CRF symptoms, physical activities are suggested as first-line interventions, mind-body therapies have been shown to be effective, and music therapy can also reduce anxiety and stress in breast cancer patients. Tango therapy that combines various elements can have an impact on physical, psychological, and cognitive abilities and could therefore have a beneficial effect on breast cancer patients. The purpose of this study is to investigate whether a 6-week tango module is suited as a therapeutic approach for people after primary breast cancer therapy to favorably influence their quality of life, especially CRF levels. Methods Sixty patients with a diagnosis for stage I–III breast cancer 12–48 months before enrollment and with CRF (age > 18) will be recruited and randomized 1:1 to a tango or a waiting-list group. Movement concepts using elements of Argentine tango (self-awareness, musical and spatial perception, self-perception, playfulness, shared experience) will be examined with the participants during six consecutive weekly 1-h tango sessions. The primary outcome will be the improvement of CRF (German version of the Cancer Fatigue Scale), and the secondary outcomes will be the improvement in sleep quality (Pittsburgh Sleep Quality Index) and quality of life (EORTC-QLQ-C30). Patient-reported outcomes will be measured at baseline and 6 weeks later; follow-up will be performed 6, 12, and 24 months after baseline. An evaluation will be performed by means of descriptive data analyses. Discussion Argentine tango, as a music-based movement therapy, can influence different skills and may improve several outcomes. The therapeutic use of Argentine tango in the care of breast cancer patients has not yet been reported. It is anticipated that participants receiving the tango module will have improved CRF, sleep, and quality of life scores compared to a waitlist control. Trial registration German Clinical Trials Registry (DRKS) DRKS00021601. Retrospectively registered on 21 August 2020

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