Higher habitual dietary flavonoid intake associates with lower central blood pressure and arterial stiffness in healthy older adults

2021 ◽  
pp. 1-28
Author(s):  
Benjamin H Parmenter ◽  
Kevin D Croft ◽  
Lachlan Cribb ◽  
Matthew B Cooke ◽  
Catherine P Bondonno ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Arterial Stiffness ◽  
Vascular Function ◽  
Dietary Quality ◽  
Central Blood Pressure ◽  
Central Hemodynamics ◽  
Healthy Older Adults ◽  
Flavonoid Intake ◽  
The Impact

Abstract Flavonoids have shown anti-hypertensive and anti-atherosclerotic properties: the impact of habitual flavonoid intake on vascular function, central hemodynamics and arterial stiffness may be important. We investigated the relationship between habitual flavonoid consumption and measures of central blood pressure and arterial stiffness. We performed cross-sectional analysis of 381 non-smoking healthy older adults (mean ± SD age, 66.0 ± 4.1 years; BMI, 26.4 ± 4.41 kg/m2; 41% male) recruited as part of the Australian Research Council Longevity Intervention (ARCLI) study. Flavonoid intake [i.e., flavonols, flavones, flavanones, anthocyanins, isoflavones, flavan-3-ol monomers, proanthocyanidins, theaflavins/thearubigins and total consumption] was estimated from food-frequency questionnaires using the US Department of Agriculture food composition databases. Measures of central hemodynamics and arterial stiffness included systolic blood pressure (cSBP), diastolic blood pressure (cDBP), mean arterial pressure (cMAP), and augmentation index (cAIx). After adjusting for demographic and lifestyle confounders, each standard deviation (SD)/day higher intake of anthocyanins (SD=44.3 mg/day) was associated with significantly lower cDBP (−1.56 mmHg, 95% CI: −2.65, −0.48) and cMAP (−1.62 mmHg, 95% CI: −2.82, −0.41). Similarly, each SD/day higher intake of flavanones (SD=19.5 mg/day) was associated with ˜1% lower cAIx (−0.93%, 95% CI: −1.77, −0.09). These associations remained significant after additional adjustment for 1) a dietary quality score and 2) other major nutrients that may affect blood pressure or arterial stiffness (i.e., sodium, potassium, calcium, magnesium, omega-3, total protein and fibre). This study suggests a possible benefit of dietary anthocyanin and flavanone intake on central hemodynamics and arterial stiffness; these findings require corroboration in further research.

Abstract 13: Mineralocorticoid Receptor Blockade does not Result in Arterial Destiffening in Healthy Older Adults

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Demetra D Christou ◽  
Jeung-Ki Yoo ◽  
Moon-Hyon Hwang ◽  
Meredith Luttrell ◽  
Han-Kyul Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Mineralocorticoid Receptor ◽  
Augmentation Index ◽  
Stiffness Index ◽  
Double Blind ◽  
Healthy Older Adults ◽  
Carotid Artery Compliance

Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. We hypothesized that mineralocorticoid receptor (MR) activation is partly responsible for increased arterial stiffness and that MR blockade would lead to arterial destiffening in healthy older adults. To test this hypothesis, we administered in a randomized, double blind, crossover study, 100 mg of Eplerenone (MR blocker) or placebo once per day for one month with one month washout, in 23 healthy older adults (age, 64±1 years; mean±SE) and assessed arterial stiffness (aortic, arm and leg pulse wave velocity (PWV; doppler flowmeter) and carotid artery compliance, distensibility, beta-stiffness index, augmentation index (high resolution ultrasonography and applanation tonometry). Despite reductions in blood pressure in response to Eplerenone (systolic blood pressure: 127±3 vs. 120±2 mmHg, P=0.01; diastolic blood pressure: 74±1 vs.72±1 mmHg, P=0.02; placebo vs. Eplerenone), arterial stiffness did not change (aortic PWV, 9.2±1.2 vs. 8.9±1.2m/sec, P=0.5; arm PWV, 11.4±0.6 vs. 11.7±0.7 m/sec, P=0.7; leg PWV, 13.4±0.4 vs.12.8±0.5 m/sec, P=0.3; carotid artery compliance, 0.17±0.02 vs. 0.16±0.02 mm 2 /mmHg, P=0.6; distensibility, 12.7±1.6 vs.13.6±1.5 10 -3 kPa -1 , P=0.6; beta stiffness index, 3.2±0.3 vs. 3.4±0.3, P=0.5; augmentation index, 24.3±2.9 vs. 22.0±2.9 %, P=0.3, placebo vs. Eplerenone). In conclusion, MR blockade does not result in arterial destiffening in healthy older adults despite reductions in blood pressure.

scholarly journals THE IMPACT OF SMOKING AND SMOKING CESSATION ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE

2016 ◽  
Vol 67 (13) ◽  
pp. 2023
Author(s):  
Adam D. Gepner ◽  
Megan Piper ◽  
Claudia Korcarz ◽  
Kristin Hansen ◽  
JoAnne Weber ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Smoking Cessation ◽  
Arterial Stiffness ◽  
Central Blood Pressure ◽  
The Impact

The Impact of Stereotype Threat on Memory and Cognition in Older Adults

2021 ◽  
pp. 019394592110297
Author(s):  
Graham J. McDougall ◽  
Todd B. Monroe ◽  
Keenan A. Pituch ◽  
Michael A. Carter ◽  
Laurie Abbott
Keyword(s):  
Older Adults ◽  
Stereotype Threat ◽  
Verbal Memory ◽  
Memory Performance ◽  
Training Group ◽  
Memory Training ◽  
Unique Contribution ◽  
Healthy Older Adults ◽  
Bivariate Correlation ◽  
The Impact

Cultural stereotypes that equate aging with decreased competence and increased forgetfulness have persisted for decades. Stereotype threat (ST) refers to the psychological discomfort people experience when confronted by a negative, self-relevant stereotype in a situation where their behavior could be construed as confirming that belief. The purpose of this study was to examine the relationships of ST on memory performance in older adults over 24 months. The ST levels on average significantly declined, or improved in the memory training, but not the health training group. Although not significant at the .01 level, the bivariate correlation indicated that change in ST was moderately related to change in verbal memory, suggesting the possibility that improvements (or reductions) in ST may be related to increases in verbal memory scores. We discovered that the unique contribution of ST into the memory performance of healthy older adults offers a possible malleable trait.

scholarly journals Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1003
Author(s):  
Elena Vega-Martín ◽  
Marta Gil-Ortega ◽  
Raquel González-Blázquez ◽  
Sara Benedito ◽  
Jesús Fernández-Felipe ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arterial Stiffness ◽  
Thoracic Aorta ◽  
Vascular Function ◽  
Saturated Fatty Acids ◽  
Vascular Wall ◽  
Monounsaturated Fatty Acids ◽  
Mesenteric Arteries ◽  
Monounsaturated Fat ◽  
The Impact

Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high-oleic-acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans-fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA-enriched high-fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five-week-old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil-enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil-enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the β-index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity-related vascular alterations that is exacerbated by SFA.

scholarly journals Feasibility of non‐invasive measurement of central blood pressure and arterial stiffness in shock

2021 ◽  
Author(s):  
Konstantinos Markakis ◽  
Nikolaos Pagonas ◽  
Eleni Georgianou ◽  
Panagiota Zgoura ◽  
Benjamin J. Rohn ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Central Blood Pressure ◽  
Non Invasive ◽  
Invasive Measurement

The impact of acute exercise on cognitive function in healthy older adults

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e402-e403
Author(s):  
J. Fortune ◽  
I. Robertson ◽  
A. Kelly ◽  
J. Hussey
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Acute Exercise ◽  
Healthy Older Adults ◽  
The Impact

scholarly journals Food Insecurity and Dietary Quality in Older Adults: Do Nutrition Assistance Programs Play a Protective Role?

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1379-1379
Author(s):  
Nicholas Bishop ◽  
Sarah Ullevig ◽  
Krystle Zuniga ◽  
Kaipeng Wang
Keyword(s):  
Older Adults ◽  
Food Insecurity ◽  
Healthy Eating Index ◽  
Dietary Quality ◽  
Linear Modeling ◽  
Assistance Programs ◽  
Supplemental Food ◽  
Nutrition Assistance ◽  
Nutrition Assistance Programs ◽  
The Impact

Abstract Objectives The emergence of food insecurity as a primary nutrition-related health issue among older adults suggests a need to examine how nutritional assistance programs are related to food insecurity and dietary quality in aging populations. This project examines food insecurity and dietary quality in US adults age 65 and older and the impact of nutrition assistance programs. Methods The sample was drawn from the 2012 Health and Retirement Study and 2013 Health Care and Nutrition Study and included 3779 respondents representing a population of 37,217,566 adults aged 65 and older. Food insecurity was a binary measure based on the USDA six-item US Adult Food Security Survey Module. Two forms of nutritional assistance included receipt of supplemental food from sources such as food banks and Meals-on-Wheels (1 = yes, 0 = no) and reported receipt of SNAP benefits (1 = yes, 0 = no). Dietary quality was measured using the Alternative Healthy Eating Index-2010 based on a food frequency questionnaire. General linear modeling adjusting for covariates and complex sampling design was used to test if nutritional assistance moderated the association between food insecurity and AHEI-2010. Results Around 10% of the sample was food insecure, 14% reported receipt of supplemental food, and 6.4% were SNAP benefit recipients. In covariate-adjusted models, food insecurity and receipt of SNAP benefits were not associated with AHEI-2010, but receipt of supplemental food was (b = −1.39, SE = 0.67, P = 0.038). Receipt of supplemental food moderated the association between AHEI-2010 and food insecurity (P = 0.001). Simple effect estimates suggested that among those not receiving supplemental food, the food insecure had lower AHEI-2010 scores than the food secure (b = −2.15, SE = 0.88, P = 0.014). Among those receiving supplemental food, the food insecure had greater AHEI-2010 scores than the food secure (b = 2.62, SE = 1.25, P = 0.035) and similar AHEI-2010 scores as the food secure not receiving supplemental food. Conclusions Preliminary analysis suggests that receipt of supplemental food appears to be associated with better dietary quality among food-insecure older adults and confirms the importance of food assistance programs in combating the negative effect of food insecurity on dietary quality. Funding Sources This work is supported by the Texas State University Research Enhancement Program.

Estimates of arterial stiffness and central blood pressure in patients with type 2 diabetes: A comparison of SphygmoCor and Arteriograph

2016 ◽  
Vol 16 (C) ◽  
pp. 18 ◽  
Author(s):  
Christoffer Krogager ◽  
Niklas B. Rossen ◽  
Klavs W. Hansen ◽  
Søren T. Knudsen ◽  
Christian D. Peters ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Arterial Stiffness ◽  
Central Blood Pressure
Sign in / Sign up

Export Citation Format

Share Document