Interactions between dietary flavonoids and the gut microbiome: a comprehensive review

2021 ◽  
pp. 1-15
Author(s):  
Mostafa Hassan Baky ◽  
Mostafa Elshahed ◽  
Ludger Wessjohann ◽  
Mohamed A. Farag
Keyword(s):  
Gut Microbiota ◽  
Chemical Structure ◽  
Biological Activities ◽  
Physiological Changes ◽  
Gi Tract ◽  
In Planta ◽  
Natural Polyphenol ◽  
Biotransformation Products ◽  
Dietary Flavonoids

Abstract Flavonoids are natural polyphenol secondary metabolites that are widely produced in planta. Flavonoids are ubiquities in human dietary intake and exhibit a myriad of health benefits. Flavonoids-induced biological activities are strongly influenced by their in situ availability in the human GI tract, as well as the levels of which are modulated by interaction with the gut bacteria. As such, assessing flavonoids–microbiome interactions is considered a key to understand their physiological activities. Here, we review the interaction between the various classes of dietary flavonoids (flavonols, flavones, flavanones, isoflavones, flavan-3-ols and anthocyanins) and gut microbiota. We aim to provide a holistic overview of the nature and identity of flavonoids on diet and highlight how flavonoids chemical structure, metabolism and impact on humans and their microbiomes are interconnected. Emphasis is placed on how flavonoids and their biotransformation products affect gut microbiota population, influence gut homoeostasis and induce measurable physiological changes and biological benefits.

scholarly journals A Further Comprehensive Review on the Phytoconstituents from the Genus Erythrina

2020 ◽  
Vol 23 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Mohammad Musarraf Hussain
Keyword(s):  
Chemical Structure ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmaceutical Journal ◽  
Significant Source ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Previous Review

Erythrina is a significant source of phytoconstituents. The aim of this review is to solicitude of classification, synthesis, and phytochemicals with biological activities of Erythrina. In our previous review on this genus (Hussain et. al., 2016a) fifteen species (Erythrina addisoniae, E. caribeae, E. indica, E. lattisima, E. melanacantha, E. mildbraedii, E. poeppigiama, E. stricta, E. subumbrans, E. veriagata, E. vespertilio, E. velutina, E. zeberi, E. zeyheri and E. americana) have been studied and 155 molecules with chemical structures were reported. A further comprehensive review was done upon continuation on the same genus and thirteen species (E. abyssinica, E. arborescens, E. berteroana, E. burttii, E. caffra, E. coralloids, E. crista-galli, E. fusca, E. herbaceae, E. lysistemon, E. mulungu, E. speciosa and E. tahitensis) of Erythrina have been studied and 127 compounds are reported as phytoconstituents with their chemical structure in this review. Erythrina crista-galli and E. lysistemon consist of highest number of chemical constituents. Bangladesh Pharmaceutical Journal 23(1): 65-77, 2020

scholarly journals FLAVONOIDS NUTRACEUTICALS IN PREVENTION AND TREATMENT OF CANCER: A REVIEW

2018 ◽  
Vol 11 (1) ◽  
pp. 42 ◽  
Author(s):  
Robert Lotha ◽  
Arvind Sivasubramanian
Keyword(s):  
Red Wine ◽  
Biological Activities ◽  
Health Benefits ◽  
Epidemiological Studies ◽  
Anticancer Properties ◽  
Prevention And Treatment ◽  
Flavonoid Intake ◽  
Meta Analyses ◽  
Dietary Flavonoids ◽  
Broad Aspect

The objective of the study was to discuss the preventive and treatment of cancer from flavonoids nutraceuticals from our daily dietary source. There has been increasing interest in the research of flavonoids from dietary sources, due to growing evidence of the versatile health benefits of flavonoids through epidemiological studies. Numerous biological activities have been reported. Some clinical trials or meta-analyses have suggested positive associations between flavonoid intake and human health, Several findings have proven that dietary flavonoids to have anticancer properties. Flavonoids due to their nontoxicity in nature and vast, broad aspect of its benefits in biological activities have been intensively studied for their health benefits also added to its abundant availability in our daily diets, for example, green leaves, fruits, red wine, and tea vegetables.

scholarly journals Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship

Animals ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 145
Author(s):  
Małgorzata Gieryńska ◽  
Lidia Szulc-Dąbrowska ◽  
Justyna Struzik ◽  
Matylda Barbara Mielcarska ◽  
Karolina Paulina Gregorczyk-Zboroch
Keyword(s):  
Epithelial Cells ◽  
Gut Microbiota ◽  
Metabolic Diseases ◽  
Intestinal Barrier ◽  
Intercellular Junctions ◽  
Gi Tract ◽  
First Line ◽  
Mucosal Integrity ◽  
Physical Defense ◽  
Mutualistic Relationship

The gastrointestinal tract, which is constantly exposed to a multitude of stimuli, is considered responsible for maintaining the homeostasis of the host. It is inhabited by billions of microorganisms, the gut microbiota, which form a mutualistic relationship with the host. Although the microbiota is generally recognized as beneficial, at the same time, together with pathogens, they are a permanent threat to the host. Various populations of epithelial cells provide the first line of chemical and physical defense against external factors acting as the interface between luminal microorganisms and immunocompetent cells in lamina propria. In this review, we focus on some essential, innate mechanisms protecting mucosal integrity, thus responsible for maintaining intestine homeostasis. The characteristics of decisive cell populations involved in maintaining the barrier arrangement, based on mucus secretion, formation of intercellular junctions as well as production of antimicrobial peptides, responsible for shaping the gut microbiota, are presented. We emphasize the importance of cross-talk between gut microbiota and epithelial cells as a factor vital for the maintenance of the homeostasis of the GI tract. Finally, we discuss how the imbalance of these regulations leads to the compromised barrier integrity and dysbiosis considered to contribute to inflammatory disorders and metabolic diseases.

scholarly journals 3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

2008 ◽  
Vol 63 (9-10) ◽  
pp. 639-643 ◽  
Author(s):  
Omar Santana ◽  
Matías Reina ◽  
Ana Luisa Anaya ◽  
Fidel Hernández ◽  
M. Elena Izquierdo ◽  
...  
Keyword(s):  
Leptinotarsa Decemlineata ◽  
Chemical Structure ◽  
Spectroscopic Analysis ◽  
Biological Activities ◽  
Protective Role ◽  
Panicum Maximum ◽  
Amaranthus Hypochondriacus ◽  
Plant Defensive Compounds ◽  
Polyphagous Insect ◽  
Rottboellia Cochinchinensis

In the context of the study on plant defensive compounds we have isolated the main alkaloid from Hippeastrum puniceum (Amaryllidaceae), 3-O-acetyl-narcissidine (1), and its biological activities tested against two divergent insect species and several plant species. 1 was isolated from the bioactive alkaloidal fraction of H. puniceum. Its chemical structure was established by spectroscopic analysis. The biological activity tests showed that 1 is an antifeedant against the polyphagous insect Spodoptera littoralis but not against the olyphage Leptinotarsa decemlineata. Furthermore, the root growth of Amaranthus hypochondriacus, Rottboellia cochinchinensis, Panicum maximum and Solanum lycopersicum was significantly affected by 1. These results suggest a plant protective role for H. puniceum alkaloids.

A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance through effects on the gut microbiota

2022 ◽  
pp. candisc.0808.2021
Author(s):  
Meriem Messaoudene ◽  
Reilly Pidgeon ◽  
Corentin Richard ◽  
Mayra Ponce ◽  
Khoudia Diop ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Gut Microbiota ◽  
Natural Polyphenol

scholarly journals Structural Analysis of Fucoidans

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Maria I. Bilan ◽  
Anatolii I. Usov
Keyword(s):  
Biological Activity ◽  
Structural Analysis ◽  
Charge Density ◽  
Brown Algae ◽  
Uronic Acid ◽  
Chemical Structure ◽  
Biological Activities ◽  
Biological Properties ◽  
Sulfated Polysaccharides ◽  
New Information

Sulfated polysaccharides of brown algae (“fucoidans”) constitute a wide variety of biopolymers from simple sulfated fucans up to complex heteropolysaccharides composed of several neutral monosaccharides, uronic acid and sulfate. The increased interest in this class of polysaccharides is explained by their high and versatile biological activities, and hence, by their possible use in new drug design. Structural analysis of several fucoidans demonstrates that their biological properties are determined not only by charge density, but also by fine chemical structure, although distinct correlations between structure and biological activity cannot be formulated at present. The aim of this review is to describe the methods of structural analysis currently used in fucoidan chemistry, and to discuss some new information on the structures of fucoidans presented in recent publications.

scholarly journals Agrobiological Interactions of Essential Oils of Two Menthol Mints: Mentha piperita and Mentha arvensis

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 59 ◽  
Author(s):  
Danuta Kalemba ◽  
Agnieszka Synowiec
Keyword(s):  
Biological Activities ◽  
Review Article ◽  
Mentha Piperita ◽  
Agricultural Pest ◽  
Mentha Arvensis ◽  
Botanical Pesticides ◽  
New Methods ◽  
In Situ Experiments

This review article discusses the active constituents and potential of two menthol mint oils, Mentha piperita (MPEO) and Mentha arvensis (MAEO), as natural sources for botanical pesticides. The biological activities of these menthol mint oils, which can be useful in agriculture, have been broadly researched, especially toward phytotoxic microorganisms. To a lesser extent, the insecticidal and herbicidal activities of mint EOs have also been studied. It is apparent that the prospect of using menthol mint oils in agriculture is increasing in popularity. A number of investigations showed that the in vitro efficacy of MPEO and MAEO, as well as that of their main constituent, menthol, is pronounced. The results of in vitro research are useful for choosing EOs for further investigations. However, it is clear that in situ experiments are crucial and should be more extensively developed. At the same time, known techniques are to be applied to this area and new methods should be worked out, aiming at the improvement of EOs’ pesticidal efficacy and cost-effectiveness, for future implementation in agricultural pest control.

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