Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study

2011 ◽  
Vol 126 (2) ◽  
pp. 180-184 ◽  
Author(s):  
S I Adam ◽  
K M Wilson ◽  
S M Overholser ◽  
E Khabbaz ◽  
K Moreno ◽  
...  
Keyword(s):  
Head And Neck ◽  
Blood Group ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Laryngeal Carcinoma ◽  
Survival Rates ◽  
Blood Type ◽  
Advanced Stage Cancer ◽  
Abo Blood Grouping ◽  
Blood Grouping

AbstractObjective:Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality.Methods:Of 271 patients treated for squamous cell laryngeal carcinoma (1997–2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared.Results:There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001).Conclusion:Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.

scholarly journals Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

2021 ◽  
pp. 310-316
Author(s):  
T. Mitila ◽  
P. S. Muthu Subramanian ◽  
Chitra Srinivasan ◽  
Vimal Chander
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Blood Group ◽  
Histological Grade ◽  
Tertiary Care ◽  
Blood Type ◽  
Early Screening ◽  
Tertiary Care Centre ◽  
Abo Blood Grouping ◽  
Blood Grouping

Background: Globally, breast cancer contributes to 27.7% of the newly diagnosed cases of cancer among women. Early screening and timely diagnosis of the lesions of breast help in alleviating the anxiety among patients. Histopathology is the gold standard in diagnosing the lesions, assessing the adequacy of treatment, and in disease prognosis. Studies have shown that ABO blood type has been associated with risk and survival for several malignancies. However, data for an association with breast cancer are inconsistent. Aim: To study the histopathological spectrum breast carcinomas and to investigate the presence of a possible association between breast cancer in women and ABO blood group and Rh factor. Materials and Methods: This retrospective descriptive study was done for a period of 4 years on 110 mastectomy specimens histopathologically diagnosed as breast cancers, and clinico-pathological data collected and analysed with records from the Department of Pathology, Saveetha Medical College. Association of breast cancer with ABO blood grouping and Rh typing was studied.  Results: Left breast was involved in most cases (96.4%). The mean age was 50.86 years, with 41-50 years age group showing peak incidence. Infiltrating breast carcinoma, no special type (89.6%) was the most common histological type. ER and PR positivity was seen in 46.4% and 41.8% of cases respectively. A statistically significant association was seen between hormone receptor status and histological grade. 39.1% cases belonged to O blood group, and Rh positivity was seen in 96.4% of the cases. No association was found between breast cancer and ABO/Rh blood grouping.

Expression of A9 Antigen and Loss of Blood Group Antigens as Determinants of Survival in Patients with Head and Neck Squamous Carcinoma

1987 ◽  
Vol 96 (3) ◽  
pp. 221-230 ◽  
Author(s):  
Thomas E. Carey ◽  
Gregory T. Wolf ◽  
S. Hsu ◽  
J. Poore ◽  
K. Peterson ◽  
...  
Keyword(s):  
Head And Neck ◽  
Blood Group ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Primary Tumor Site ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

The murine monoclonal antibody (A9), raised to the human squamous cell carcinoma (SCC) cell-line UM-SCC-1, defines a squamous cell antigen associated with aggressive biologic behavior of SCC cell lines in vivo and in vitro. In the present investigation, A9 antigen was detected in tissue sections from 37 consecutive, previously untreated patients with SCC of the head and nack. All tumors were positive for A9 binding, although three distinct patterns (reflecting different intensities of A9 expression) were identified. The intensity of A9 expression was independent of primary tumor site, tumor differentiation, keratinization, or growth pattern. The frequency of high expression (Pattern 1) grew with increasing T class, N class, and tumor stage, and was associated with loss of blood group expression in the tumor and with low levels of lymphocyte infiltration In the tumor. Strong A9 expression had a statistically signification association with low nuclear grade (i.e., tumors with more mature and fewer enlarged nuclei, P = 0.019), low vascular/stromal response (i.e., patchy response rather than continuous, P = 0.014), and impaired in vitro lymphokine production by peripheral blood leukocytes ( P = 0.0011). Of greatest interest, however, was the strong association of high A9 expression with shortened disease-free interval (DFI) ( P = 0.085) and survival ( P = 0.081) relative to patients with weak A9 tumor staining (Patterns 2 and 3). Similarly, the loss of blood group antigen expression was strongly associated with decreased DFI ( P = 0.038) and survival ( P = 0.062). While neither Pattern 1 A 9 expression nor loss of blood group reach statistical significance in prediction of survival, the combination of Pattern 1 A 9 expression and loss of blood group expression in primary tumors was significantly associated, both with decreased disease-free interval ( P = 0.017) and with decreased overall survival ( P = 0.011) (median length of follow-up = 22 months). The length of follow-up (LFU) ranged from 2 to 38 months, with a median LFU of 22 months. While the number of patients (37) is small, the significant association between the expression of these cell-surface markers with relapse and survival indicates that immunohistologic staining of the primary tumor will be an important prognostic indicator useful in identification of individual patients at greatest risk of recurrence or early death from head and neck cancer, independent of tumor size, site, or stage at presentation. These markers may thus provide means of selecting patients who should receive adjuvant therapy and more intensive monitoring for the early detection of recurrent disease.

scholarly journals DISTRIBUTION OF ABO AND RH (D) BLOOD GROUPS AMONG BLOOD DONORS IN DISTRICT MARDAN, PAKISTAN

1969 ◽  
Vol 3 (2) ◽  
pp. 318-322
Author(s):  
MUHAMMAD KHALID ◽  
NAILA ASLAM ◽  
MUHAMMAD SIYAR ◽  
RASHID AHMAD
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Local Community ◽  
Healthy Adult ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Cross Sectional ◽  
Group B ◽  
Abo Blood Grouping ◽  
Blood Grouping

OBJECTIVE: To find out the distribution of ABO and Rh (D) blood groups among blood donors in districtMardan and to help transfusion services in the area.STUDY DESIGN: Cross sectional descriptive study.MATERIALS AND METHODS: The study was conducted in DHQ Hospital Mardan from 1st January2012 to 31st December 2012. A total of 2893 healthy adult, blood donors (both volunteer and directed) fromdistrict Mardan were included. Two ml of blood anti-coagulated with EDTA was taken and both ABO andRh (D) blood groups were determined using commercially available anti-sera of Biolaboratories. Thedistribution ofABO and Rh blood groups in the local community were then calculated.RESULTS: Among ABO blood groups “ B” (27.97%) was the most prevalent, followed by “0” (27.93%),“ A” (24.75%) and “ AB” (19.36%). Group Rh positive (94.30%) was more prevalent than Rh negative(5.70%). Similarly 0+ve (26.65%) was most frequent followed by B+ve (26.17%), A+ve (23.16%), AB+ve(18.32%), B've(1.80%),Ave(l.59%),O ve( 1.28%) and ABve( 1.04%).CONCLUSION: Blood group 'B' was most frequent among the ABO blood groups and Rh (D) positiveamong Rh blood groups while0+vewas the most frequent blood group in the study population.KEYWORDS: ABO Blood grouping, Rh (D) blood grouping, Mardan.

scholarly journals Neoadjuvant docetaxel and cisplatin chemotherapy followed by local irradiation is highly active on locoregionally advanced squamous cell carcinoma of the head and neck

2007 ◽  
Vol 122 (7) ◽  
pp. 722-727 ◽  
Author(s):  
H-J Shin ◽  
J S Chung ◽  
Y J Choi ◽  
B J Lee ◽  
S G Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Remission Rate ◽  
Survival Rates ◽  
Severe Toxicity ◽  
Advanced Squamous Cell Carcinoma ◽  
Highly Active ◽  
Grade 3

AbstractThe purpose of this study was to determine the treatment outcome of neoadjuvant docetaxel and cisplatin chemotherapy followed by local radiotherapy for chemotherapy-naïve patients with locoregionally advanced squamous cell carcinoma of the head and neck. Thirty-seven patients with stage III or IV squamous cell carcinoma of the head and neck who received docetaxel and cisplatin regimen for a maximum of three cycles followed by radiation therapy were enrolled in this study. The overall response rate to the regimen was 91.9 per cent (34 of 37) (the complete remission rate was 48.6 per cent). The median time to treatment failure was 38 months (95 per cent confidence interval, 15–61 months). The four year estimated overall survival rates were 85.1 per cent. The most frequent moderate-to-severe toxicity was grade 3–4 neutropenia. The most common acute non-haematologic toxicities included anorexia, nausea and asthenia. Neoadjuvant docetaxel and cisplatin chemotherapy followed by radiotherapy is a feasible treatment strategy for patients with locoregionally advanced squamous cell carcinoma of the head and neck.

scholarly journals Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Shirley K. Knauer
Keyword(s):  
Head And Neck ◽  
Nuclear Receptors ◽  
Squamous Cell ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Survival Rates ◽  
Squamous Cell Carcinomas ◽  
High Rate ◽  
Second Primary ◽  
Tumor Entity

Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers. Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades. Thus, the need for novel treatment options for this tumor entity is undeniable. A key event in carcinogenesis is the uncontrolled modulation of genetic programs. Nuclear receptors belong to a large superfamily of transcription factors implicated in a broad spectrum of physiological and pathophysiological processes, including cancer. Several nuclear receptors have also been associated with head and neck cancer. This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity.

scholarly journals Frequency of ABO-Rhesus Blood Groups in the Western Region of Saudi Arabia

2018 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
Faisal M. Alzahrani ◽  
Saeed S. Shaikh ◽  
Muzaheed A. Rasheed
Keyword(s):  
Social Sciences ◽  
Saudi Arabia ◽  
Blood Group ◽  
Blood Groups ◽  
Western Region ◽  
Western Area ◽  
Group A ◽  
The Western Region ◽  
Abo Blood Grouping ◽  
Blood Grouping

The western region of Saudi Arabia is known as a multinational region with different ethnic groups of people. This study aims to evaluate the ABO and rhesus blood groups among study subjects in the Western area of Saudi Arabia and their comparison with other regions of the Kingdom. It is a retrospective study. 35,388 participants were included. ABO blood grouping was done using tube method. Agglutination in any tube or hemolysis was considered as positive. Blood grouping was done by a preliminary finger prick, and was repeated again and a serum sample was obtained at the time of donation. Statistical Package for Social Sciences software was used for the data analysis. Results showed that the most common blood group is O, (50.1%) followed by A (29.7%), B (16%) and less frequent is AB (4.1%). Rhesus positive were 91.3%, while rhesus negative were 8.63%. These results demonstrate that the most common blood group in the Western province is O. Blood group A was noticed to be less frequent. Understanding the frequencies of the blood groups and their phenotypes is crucial for blood banking and for setting transfusion service protocols.  

scholarly journals Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study

2020 ◽  
pp. 486-499 ◽  
Author(s):  
Renata Abrahão ◽  
Sandra Perdomo ◽  
Luis Felipe Ribeiro Pinto ◽  
Flávia Nascimento de Carvalho ◽  
Fernando Luis Dias ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
South America ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cox Regression ◽  
Survival Rates ◽  
Stage Iv ◽  
Neck Squamous Cell Carcinoma ◽  
Stage Iv Disease

PURPOSE Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America.

scholarly journals ABO Blood Group in Patients with Peptic Ulcer Disease: Association with Secretor Status

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Muhammad Naveed Akhtar ◽  
Auhammad Tayyib ◽  
Tahira Tasneem ◽  
Anjum Rashid Butt
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Blood Group ◽  
Abo Blood Group ◽  
Direct Agglutination Test ◽  
Ulcer Disease ◽  
Secretor Status ◽  
Abo Blood Grouping ◽  
Group Association ◽  
Blood Grouping

Aims and objective of the study is to find ABO blood group association with secretor status in peptic ulcer disease patients. ABO blood grouping by direct agglutination test and secretor status by agglutination inhibition test. 50 controls and 50 endoscopically diagnosed PUD patients were selected. Blood group O is associated with duodenal ulcer but no association with secretor status was found.

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