Ultrastructural Changes Associated with Alcoholic Hyalin in Hepatocytes and Biliary Epithelial Cells

Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti

To learn more of the nature and origin of alcoholic hyalin (AH), 15 liver biopsy specimens from patients with alcoholic hepatitis were studied in detail.AH was found not only in hepatocytes but also in ductular cells (Figs. 1 and 2), although in the latter location only rarely. The bulk of AH consisted of a randomly oriented network of closely packed filaments measuring about 150 Å in width. Bundles of filaments smaller in diameter (40-90 Å) were observed along the periphery of the main mass (Fig. 1), often surrounding it in a rim-like fashion. Fine filaments were also found close to the nucleus in both hepatocytes and biliary epithelial cells, the latter even though characteristic AH was not present (Figs. 3 and 4). Dispersed among the larger filaments were glycogen, RNA particles and profiles of endoplasmic reticulum. Dilated cisternae of endoplasmic reticulum were often conspicuous around the periphery of the AH mass. A limiting membrane was not observed.

Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti

Biliary epithelial cells have previously been shown to be a site of alcoholic hyalin (AH) deposition. To learn more of the nature and pathogenesis of this inclusion, the fine structure of proliferating biliary ductules was studied in 20 patients with alcoholic liver disease. The changes were compared with those observed in hepatocytes containing alcoholic hyalin.The ductular cells often displayed dilated cisternae of rough endoplasmic reticulum, prominent Golgi complexes, and an increase in lysosomes. Mitochondria were larger, more numerous and contained more cristae than those usually seen in ductules (Fig. 1). Double nuclei were common. Dense, compact cells, probably degenerative in nature, were often noted.


1987 ◽  
Vol 37 (12) ◽  
pp. 1867-1878
Author(s):  
Shin-ichi Itagaki ◽  
Kazuhito Honjo ◽  
Kunio Dor ◽  
Tomotari Mitsuoka

Author(s):  
Kazushige Hirosawa ◽  
Eichi Yamada

The pigment epithelium is located between the choriocapillary and the visual cells. The pigment epithelial cell is characterized by a large amount of the smooth endoplasmic reticulum (SER) in its cytoplasm. In addition, the pigment epithelial cell of some lower vertebrate has myeloid body as a specialized form of the SER. Generally, SER is supposed to work in the lipid metabolism. However, the functions of abundant SER and myeloid body in the pigment epithelial cell are still in question. This paper reports an attempt, to depict the functions of these organelles in the frog retina by administering one of phospholipid precursors.


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