The utility of naming tests in the diagnosis of Alzheimer's disease

1999 ◽  
Vol 16 (2) ◽  
pp. 43-46 ◽  
Author(s):  
Robert F Coen ◽  
Nicholas Kidd ◽  
Aisling Denihan ◽  
Conal Cunningham ◽  
Irene Bruce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Memory Deficits ◽  
Word Recall ◽  
Semantic Fluency ◽  
Hippocampal Region ◽  
Boston Naming Test ◽  
Naming Test ◽  
Temporal Neocortex

AbstractObjectives: To evaluate the sensitivity of the CAMCOG naming subscale to anomia in Alzheimer's disease (AD) patients identified as anomic on the Boston Naming Test (BNT); and to compare the sensitivities of BNT, category (semantic) fluency (CF), and episodic memory (Delayed Word Recall, DWR) in detecting AD.Method: Data from 140 probable AD patients (NINCDS/ADRDA) were analysed. Anomic AD patients were identified (BNT) and the sensitivity to anomia of the CAMCOG naming subscale was calculated. Sensitivity (to AD) and specificity of the BNT, CF and DWR were compared in a subgroup of 60 patients age-matched to controls.Results: On BNT 81% of ADs were classified as anomic (87% specificity). Of these anomic ADs, 23 scored 6/6 on CAMCOG naming (sensitivity = 80%), and sensitivity fell to 30% using a 5/6 cut-off. Correlation between BNT and CAMCOG naming yielded Kendall's tau = 0.48 (p<0.0001). Compared to age-matched controls BNT correctly classified 70% of ADs and 87% of controls (overall accuracy = 77%). On CF 68% of ADs and 83% of controls were correctly classified (overall accuracy = 72%). BNT and CF were moderately correlated (r = 0.49, p<0.0001). DWR correctly classified 93% ADs and 98% controls (overall accuracy = 95%).Conclusions: Given its brevity, we recommend the inclusion of a split-half form of the BNT in screening test batteries for the detection of AD. The observed pattern of cognitive impairment is consistent with current models in which semantic memory deficits occur in AD only when the neuropathology extends beyond the entorhinal/hippocampal region to the temporal neocortex.

Memory impairment in Alzheimer's disease: replication and extension of the delayed word recall (DWR) test

1996 ◽  
Vol 13 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Robert F Coen ◽  
Gregory RJ Swanwick ◽  
Conor Maguire ◽  
Michael Kirby ◽  
Brian A Lawlor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Free Recall ◽  
Recognition Performance ◽  
Word Recall ◽  
Control Subjects ◽  
Clinical Interest ◽  
Delayed Recognition ◽  
Sensitivity Specificity

AbstractObjective: The original DWR test, which measured delayed free recall, was reported to have high predictiveaccuracy in discriminating Alzheimer's disease (AD) patients from control subjects (overall accuracy of 95%).Comparison of differential performance in free recall and recognition of the same material may be of clinical interest. In the present study a delayed recognition component was added to the DWR test and the utility of both measures in discriminating AD patients from control subjects was evaluated.Procedure: This extended version of the DWR test was administered to 66 patients meeting NINCDS/ADRDA criteria for probable AD and 42 control subjects.Results: In a comparison between 42 of these patients (MMSE range 18–29), and 42 age matched healthy controls, both the delayed free recall and recognition measures were highly accurate in distinguishing patients from controls. The free recall measure achieved 98% sensitivity, specificity and overall accuracy, while the recognition measure yielded 98% sensitivity, 95% specificity, and 96% overall accuracy. The recognition performance of all 66 patients, ranging in severity from very mild to severe (MMSE range 11–29), was also evaluated to determine its relationship, if any, to measures of global cognitive impairment. While therecognition measure correlated poorly with MMSE and CAMCOG there was a modest but significant correlation with the CAMCOG memory subscale.Conclusions: In this study of highly selected AD patients both the free recall and recognition measures were sensitive and specific indicators of AD compared to control subjects. Recognition performance appears to be more closely related to degree of amnesia than to degree of global cognitive impairment.

A-7 Discriminating between Mild Cognitive Impairment and Alzheimer’s Disease on the MoCA

2021 ◽  
Vol 36 (6) ◽  
pp. 1046-1046
Author(s):  
Taylor McDonald ◽  
Craig D Marker ◽  
Lauren Ratcliffe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Pacific Islander ◽  
Word Recall ◽  
Impaired Performance ◽  
Asian Pacific Islander ◽  
Significant Difference ◽  
Asian Pacific

Abstract Objective The Montreal Cognitive Assessment (MoCA) is a suitable, sensitive, and specific cognitive screener for detecting mild cognitive impairment (MCI). Previous research has found markers to discriminate between MCI and Alzheimer’s disease (ad) on MoCA subtest scores. Specifically, impaired performance on the clock drawing (i.e., number and hand placement), rhino naming, serial 7’s, word recall, and orientation were suggestive of ad. The aim of the present study is to assess for discrimination patterns in MoCA performance between MCI and ad.Method: Data was collected through the National Alzheimer’s Coordinating Center (NACC). A sample of MCI (n = 1143; 51% female, 82% White, 15% Black, 3% Asian/Pacific Islander) and ad groups (n = 1339; 56% female, 89% White, 9% Black, 2% Asian/Pacific Islander) were examined. Results An initial independent t-test revealed a statistically significant difference in MoCA scores for MCI (M = 22.01, SD = 3.49) and ad (M = 14.46, SD = 6.05; t(2480) = 38.72, p = 0.000, Cohen’s d = 1.53). Additional t-tests were performed to compare MoCA subtest scores and domain scores for diagnostic groups. There was a statistically significant difference for MCI and ad groups across all MoCA subtests and domains. Despite no discrimination in profiles noted on t-tests, further examination using normal distribution revealed worse performance on trails, clock hands, serial 7’s, repetition, fluency, date, and place in ad groups. Conclusions Consistent with previous findings, clock hands, serial 7’s, and orientation were able to discriminate between ad and MCI. This study found further discrimination in trails, repetition, and fluency. These findings may allow for clinicians to use these patterns of performance as early cognitive markers of impairment.

P2-228: DEVELOPMENT OF A SCREENING ALGORITHM FOR ALZHEIMER'S DISEASE USING THE BOSTON NAMING TEST-SHORT VERSION

2014 ◽  
Vol 10 ◽  
pp. P558-P558
Author(s):  
Yeon Kyung Chi ◽  
Sun Young Park ◽  
Seo Yeon Kim ◽  
Kayoung Kim ◽  
Jongwoo Hong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Version ◽  
Boston Naming Test ◽  
Screening Algorithm ◽  
Naming Test

P1-466: Normative data of the Argentina version of the Boston naming test and discriminative validity for Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S262-S263
Author(s):  
Galeno Rojas ◽  
Fabian Roman ◽  
Carol Dillon ◽  
Cecilia Serrano ◽  
Leonardo Bartoloni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Normative Data ◽  
Boston Naming Test ◽  
Discriminative Validity ◽  
Naming Test

Boston Naming Test: Shortened Versions for Use in Alzheimer's Disease

1992 ◽  
Vol 47 (3) ◽  
pp. P154-P158 ◽  
Author(s):  
W. J. Mack ◽  
D. M. Freed ◽  
B. W. Williams ◽  
V. W. Henderson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Boston Naming Test ◽  
Naming Test

Differentiating illiteracy from Alzheimer's disease by using neuropsychological assessments

2011 ◽  
Vol 23 (10) ◽  
pp. 1560-1568 ◽  
Author(s):  
Jung-Hae Youn ◽  
Maryse Siksou ◽  
R. Scott Mackin ◽  
Jung-Seok Choi ◽  
Jeanyung Chey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Verbal Fluency ◽  
Verbal Learning ◽  
Boston Naming Test ◽  
Neuropsychological Measures ◽  
Drawing Test ◽  
Neuropsychological Assessments ◽  
Learning Test ◽  
Naming Test

ABSTRACTBackground: In Asia, where illiteracy rates are high, determining the degree to which neuropsychological measures can be used to identify cognitive impairment in illiterate elders is important. The aim of this study was to evaluate the effectiveness of using formal neuropsychological assessments to distinguish healthy illiterate elders from dementia patients.Methods: We compared the cognitive performance of healthy elders who were illiterate (illiterate NC, n = 25) with those who were literate (literate NC, n = 25), literate patients with mild Alzheimer's disease (literate AD, n = 25), and illiterate patients with mild AD (illiterate AD, n = 25). Neuropsychological measures included the Mini-Mental State Examination (MMSE), the verbal fluency test, the Boston naming test, the Rosen drawing test, and the verbal learning test.Results: In the between-group analyses, the scores on all tests, except verbal fluency and recognition memory, were lower for illiterate NC compared to the literate NC. The scores on the MMSE, Boston naming test, Rosen drawing test, and immediate free recall could not distinguish the illiterate NC from literate AD. However, the scores on all tests, except the Rosen drawing test, could distinguish illiterate NC from illiterate AD. ROC analyses showed the same pattern of results. In addition, age-, sex-, and education-matched cut-off scores of all tests, except immediate recall and delayed recall trials of the verbal learning test, showed good specificities in participants who were illiterate compared to those in participants who were literate.Conclusion: These findings suggest that the impact of literacy on neuropsychological test performance is an important aspect of cognitive evaluations for elders who are illiterate.

Awareness of memory deficits in subjective cognitive decline, mild cognitive impairment, Alzheimer's disease and Parkinson's disease

2014 ◽  
Vol 27 (3) ◽  
pp. 357-366 ◽  
Author(s):  
Johann Lehrner ◽  
Sandra Kogler ◽  
Claus Lamm ◽  
Doris Moser ◽  
Stefanie Klug ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Memory Deficits ◽  
Diagnostic Group ◽  
Subjective Cognitive Decline ◽  
Impaired Awareness

ABSTRACTBackground:Impaired awareness of memory deficits has been recognized as a common phenomenon in Alzheimer's disease (AD) and research is now increasingly focusing on awareness in groups at risk for future dementia. This study aimed to determine whether levels of awareness differ among healthy elderly people and patients with subjective cognitive decline (SCD), amnestic and non-amnestic subtypes of mild cognitive impairment (aMCI, naMCI), Alzheimer's disease (AD) and Parkinson's disease (PD), to explore correlates of awareness and to establish frequencies of memory over- and underestimation within each diagnostic group.Methods:756 consecutive outpatients of a memory clinic and 211 healthy controls underwent thorough neuropsychological testing. Impairment of awareness was measured as the difference between subjective memory appraisals (16-item questionnaire on current memory-related problems in everyday life) and objective memory performance (15-item delayed recall task). Subgroups of over- and underestimators were classified using percentile ranks of controls.Results:At group level, awareness significantly decreased along the naMCI→aMCI→AD continuum, with naMCI patients showing a tendency towards overestimation of memory dysfunction. PD patients showed accurate self-appraisals as long as memory function was largely unaffected. However, there was a considerable between-group overlap in awareness scores. Furthermore, different correlates of awareness were observed depending on the diagnostic group. In general, unawareness seems to be associated with decreased cognitive performance in various domains (especially memory), higher age and lower levels of depression and self-reported functional impairment.Conclusion:Impaired awareness is an important symptom in aMCI. Yet, given the considerable variability in awareness scores, longitudinal studies are required to evaluate their predictive power.

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