Hidden talents in harsh environments

2020 ◽  
pp. 1-19 ◽  
Author(s):  
Bruce J. Ellis ◽  
Laura S. Abrams ◽  
Ann S. Masten ◽  
Robert J. Sternberg ◽  
Nim Tottenham ◽  
...  
Keyword(s):  
Social Services ◽  
Current Knowledge ◽  
Childhood Adversity ◽  
Harsh Environments ◽  
Growing Up ◽  
Early Life Adversity ◽  
Diverse Range ◽  
Healthy Development ◽  
Potential Applications ◽  
Interdisciplinary Framework

Abstract Although early-life adversity can undermine healthy development, children growing up in harsh environments may develop intact, or even enhanced, skills for solving problems in high-adversity contexts (i.e., “hidden talents”). Here we situate the hidden talents model within a larger interdisciplinary framework. Summarizing theory and research on hidden talents, we propose that stress-adapted skills represent a form of adaptive intelligence that enables individuals to function within the constraints of harsh, unpredictable environments. We discuss the alignment of the hidden talents model with current knowledge about human brain development following early adversity; examine potential applications of this perspective to multiple sectors concerned with youth from harsh environments, including education, social services, and juvenile justice; and compare the hidden talents model with contemporary developmental resilience models. We conclude that the hidden talents approach offers exciting new directions for research on developmental adaptations to childhood adversity, with translational implications for leveraging stress-adapted skills to more effectively tailor education, jobs, and interventions to fit the needs and potentials of individuals from a diverse range of life circumstances. This approach affords a well-rounded view of people who live with adversity that avoids stigma and communicates a novel, distinctive, and strength-based message.

scholarly journals Identification of Determinants of Resilience in Children Using Administrative Health, Social, Justice and Education Data

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Anita Durksen ◽  
Marni Brownell ◽  
Nathan Nickel
Keyword(s):  
Social Services ◽  
Administrative Data ◽  
Early Life ◽  
Childhood Adversity ◽  
Population Data ◽  
Population Level ◽  
Childhood Experiences ◽  
Healthy Development ◽  
Education Data ◽  
Key Factor

IntroductionResilience is a key factor in healthy development of children who have experienced adversity in early life. Current methods of assessment involve using questionnaires - few of which are appropriate for young children, most are time consuming and rely on parent recall, thereby introducing bias. Additionally, widespread implementation of these would be costly, making population-level assessment of resilience impractical. The current study will leverage multi-sector, linkable, whole-population data from health, education, justice and social services to explore alternative ways to assess resilience in children. Objectives and ApproachThe purpose of this study is to identify factors in administrative data that emerge as significant determinants of resilience, demonstrated by children who experience adversity in early life but develop normally. Children born in Manitoba between 2000-2012 will be included. Adversity will be identified as families receiving income assistance, and/or the presence of adverse childhood experiences (ACEs) in linked databases such as Justice (incarcerated parent) and Health (parent with mental or substance use disorder). Development will be measured using the Early Development Instrument (EDI). EDI outcomes will be assessed according to severity and frequency of adversity. Pre-identified covariates that map onto sub-constructs of resilience will be assessed using multivariable linear regression to determine whether they are associated with higher EDI scores in the context of adversity. ResultsThe identification of administrative data variables associated with resilience in children will serve as a valuable tool for population-level assessment of resilience among children who experience adversity at young ages. Conclusion / ImplicationsWhile complete eradication of childhood adversity is unlikely, the continued development of programs and policies that build resilience in children is crucial. The results of this study will provide a means for population-level evaluation of such programs and policies, ultimately improving evidence for policy and decision-makers in the area of child development.

scholarly journals A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1566
Author(s):  
Oliver J. Pemble ◽  
Maria Bardosova ◽  
Ian M. Povey ◽  
Martyn E. Pemble
Keyword(s):  
Thin Films ◽  
Mechanical Properties ◽  
High Volume ◽  
Mechanical Anisotropy ◽  
Diverse Range ◽  
Direction Parallel ◽  
High Area ◽  
Wide Range ◽  
Slot Die ◽  
Potential Applications

Chitosan-based films have a diverse range of potential applications but are currently limited in terms of commercial use due to a lack of methods specifically designed to produce thin films in high volumes. To address this limitation directly, hydrogels prepared from chitosan, chitosan-tetraethoxy silane, also known as tetraethyl orthosilicate (TEOS) and chitosan-glutaraldehyde have been used to prepare continuous thin films using a slot-die technique which is described in detail. By way of preliminary analysis of the resulting films for comparison purposes with films made by other methods, the mechanical strength of the films produced was assessed. It was found that as expected, the hybrid films made with TEOS and glutaraldehyde both show a higher yield strength than the films made with chitosan alone. In all cases, the mechanical properties of the films were found to compare very favorably with similar measurements reported in the literature. In order to assess the possible influence of the direction in which the hydrogel passes through the slot-die on the mechanical properties of the films, testing was performed on plain chitosan samples cut in a direction parallel to the direction of travel and perpendicular to this direction. It was found that there was no evidence of any mechanical anisotropy induced by the slot die process. The examples presented here serve to illustrate how the slot-die approach may be used to create high-volume, high-area chitosan-based films cheaply and rapidly. It is suggested that an approach of the type described here may facilitate the use of chitosan-based films for a wide range of important applications.

scholarly journals Sporulation in solventogenic and acetogenic clostridia

2021 ◽  
Author(s):  
Mamou Diallo ◽  
Servé W. M. Kengen ◽  
Ana M. López-Contreras
Keyword(s):  
Current Knowledge ◽  
Carbon Sources ◽  
Cost Effective ◽  
Biotechnological Production ◽  
Key Points ◽  
Wide Range ◽  
Potential Applications ◽  
A Cell ◽  
Sporulation Initiation ◽  
Solventogenic Clostridia

AbstractThe Clostridium genus harbors compelling organisms for biotechnological production processes; while acetogenic clostridia can fix C1-compounds to produce acetate and ethanol, solventogenic clostridia can utilize a wide range of carbon sources to produce commercially valuable carboxylic acids, alcohols, and ketones by fermentation. Despite their potential, the conversion by these bacteria of carbohydrates or C1 compounds to alcohols is not cost-effective enough to result in economically viable processes. Engineering solventogenic clostridia by impairing sporulation is one of the investigated approaches to improve solvent productivity. Sporulation is a cell differentiation process triggered in bacteria in response to exposure to environmental stressors. The generated spores are metabolically inactive but resistant to harsh conditions (UV, chemicals, heat, oxygen). In Firmicutes, sporulation has been mainly studied in bacilli and pathogenic clostridia, and our knowledge of sporulation in solvent-producing or acetogenic clostridia is limited. Still, sporulation is an integral part of the cellular physiology of clostridia; thus, understanding the regulation of sporulation and its connection to solvent production may give clues to improve the performance of solventogenic clostridia. This review aims to provide an overview of the triggers, characteristics, and regulatory mechanism of sporulation in solventogenic clostridia. Those are further compared to the current knowledge on sporulation in the industrially relevant acetogenic clostridia. Finally, the potential applications of spores for process improvement are discussed.Key Points• The regulatory network governing sporulation initiation varies in solventogenic clostridia.• Media composition and cell density are the main triggers of sporulation.• Spores can be used to improve the fermentation process.

scholarly journals Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Darina Czamara ◽  
Elleke Tissink ◽  
Johanna Tuhkanen ◽  
Jade Martins ◽  
Yvonne Awaloff ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Social Services ◽  
Disease Risk ◽  
Childhood Adversity ◽  
Total Sample ◽  
Synaptic Function ◽  
Combined Effects ◽  
Self Reports ◽  
Main Effects ◽  
The Impact

AbstractLasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and prenatal environment. Here, we extend these analyses to postnatal stressors. We investigated the contribution of CA, cis genotype (G), and their additive (G + CA) and interactive (G × CA) effects to DNAm variability in blood or saliva from five independent cohorts with a total sample size of 1074 ranging in age from childhood to late adulthood. Of these, 541 were exposed to CA, which was assessed retrospectively using self-reports or verified through social services and registries. For the majority of sites (over 50%) in the adult cohorts, variability in DNAm was best explained by G + CA or G × CA but almost never by CA alone. Across ages and tissues, 1672 DNAm sites showed consistency of the best model in all five cohorts, with G × CA interactions explaining most variance. The consistent G × CA sites mapped to genes enriched in brain-specific transcripts and Gene Ontology terms related to development and synaptic function. Interaction of CA with genotypes showed the strongest contribution to DNAm variability, with stable effects across cohorts in functionally relevant genes. This underscores the importance of including genotype in studies investigating the impact of environmental factors on epigenetic marks.

scholarly journals Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4504
Author(s):  
Muhanna Al-shaibani ◽  
Radin Maya Saphira Radin Mohamed ◽  
Nik Sidik ◽  
Hesham Enshasy ◽  
Adel Al-Gheethi ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Extreme Environments ◽  
Software Tool ◽  
Gene Clusters ◽  
Well Being ◽  
Bioactive Substances ◽  
Diverse Range ◽  
Wide Range ◽  
Potential Applications

The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.

Cañihua (Chenopodium pallidicaule Aellen) a promising superfood in food industry: a review

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Jerry Fredy Gomez Cahuata ◽  
Yessica Estefany Rosas-Quina ◽  
Erika Pachari Vera
Keyword(s):  
Food Industry ◽  
Unsaturated Fatty Acids ◽  
Protein Quality ◽  
Current Knowledge ◽  
Scientific Information ◽  
Essential Amino Acids ◽  
High Concentration ◽  
Content Type ◽  
Functional Value ◽  
Potential Applications

Purpose The purpose of this paper is to divulge the current knowledge about the nutritional and functional characteristics of Cañihua (Chenopodium pallidicaule Aellen), in addition to its potential applications in the food industry since research studies related to it are still limited compared to other cereals of greater diffusion. Design/methodology/approach The scientific information was collected from Web of Science, Scopus and Google Scholar databases, using keywords such as nutrition value of Chenopodium pallidicaule, amaranth and pseudocereals. Consistent information was selected according to its relevance, year of publication and accuracy with the topic. A total of 49 research papers were selected. Findings Cañihua is a grain with high nutritional potential, considered a superfood because it has a high protein quality, a balanced composition of essential amino acids and unsaturated fatty acids, with a high concentration of linoleic and oleic acid. Besides, it has a good level of bioactive compounds with high antioxidant capacity. However, its production and consumption are limited outside its area of origin, although its cultivation is possible under harsh conditions. Originality/value This paper, through a systematic bibliographic review, highlights the potential of cañihua to be considered in the development of food products with high nutritional and functional value. The information compiled will help researchers and professionals become aware of the importance of this grain and join forces in its processing and enhancement of its attributes.

scholarly journals Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function

2014 ◽  
Vol 16 (3) ◽  
pp. 321-333 ◽  
Keyword(s):  
Stress Responses ◽  
Childhood Adversity ◽  
Adrenal Function ◽  
Early Life Adversity ◽  
Hypothalamic Pituitary Adrenal ◽  
Expression Of Genes ◽  
Epigenetic Programming ◽  
Social Adversity ◽  
Wide Range ◽  
Nonhuman Species

We review studies with human and nonhuman species that examine the hypothesis that epigenetic mechanisms, particularly those affecting the expression of genes implicated in stress responses, mediate the association between early childhood adversity and later risk of depression. The resulting studies provide evidence consistent with the idea that social adversity, particularly that involving parent-offspring interactions, alters the epigenetic state and expression of a wide range of genes, the products of which regulate hypothalamic-pituitary-adrenal function. We also address the challenges for future studies, including that of the translation of epigenetic studies towards improvements in treatments.

Soil sodicity in Victoria

Soil Research ◽  
1993 ◽  
Vol 31 (6) ◽  
pp. 869 ◽  
Author(s):  
GW Ford ◽  
JJ Martin ◽  
P Rengasamy ◽  
SC Boucher ◽  
A Ellington
Keyword(s):  
Land Degradation ◽  
Management Practices ◽  
Agricultural Land ◽  
Current Knowledge ◽  
Relevant Information ◽  
Irrigated Agriculture ◽  
Future Research ◽  
Sodic Soils ◽  
Diverse Range ◽  
Key Issues

This paper gives a broad overview of the distribution and agricultural importance of sodic soils in Victoria. Sodic soils are estimated to occupy at least 13.4 Mha, representing at least 73% of Victoria's agricultural land. Most of this land is used for dryland farming; about 85% of the cropped land and 66% of the land sown to dryland pastures occurs on sodic soils. The largest sodicity class is 'alkaline sodic', dominated by a diverse range of soils (red duplex, yellow duplex, calcareous earths and self-mulching cracking clays). Alkaline sodic soils comprise half of the total agricultural land area, or about 24% of the area of land currently used for dryland cropping and 21% of the land under sown pasture. Land degradation problems are recognized as affecting most agricultural land in Victoria, and to be substantially limiting its productivity. The nature, extent and severity of the various forms of land degradation are a consequence of both intrinsic soil properties and of management practices. There is an urgent need to improve current farming practices to prevent further deterioration of the soil resource. Existing knowledge of the behaviour of sodic soils under both dryland and irrigated agriculture is reviewed. It is concluded that substantial gains in productivity are possible, but will require effective collaboration between soil scientists, agronomists, and land managers. Collation and integration of current knowledge on the properties and management of sodic soils in Victoria, and the acquisition of additional relevant information by targeted long-term research is required. Key issues for future research are identified.

Mitigating the Impact of Forced Displacement and Refugee and Unauthorized Status on Youth

2018 ◽  
pp. 186-206
Author(s):  
Hirokazu Yoshikawa ◽  
Alice J. Wuermli ◽  
J. Lawrence Aber
Keyword(s):  
Social Services ◽  
Migration Policy ◽  
Children And Youth ◽  
Cultural Variation ◽  
Risk And Resilience ◽  
Refugee Status ◽  
Healthy Development ◽  
Political Upheaval ◽  
And Migration ◽  
Primary School Age

An unprecedented half of the world’s 57 million out of school children live in conflict-affected countries, and 50% of children of primary-school-age are not attending school.  In addition, the unauthorized status of many refugees and migrants worldwide is associated with experiences of social exclusion as access to employment and social services are often unavailable or constrained by host-country governments. Children and youth affected by unauthorized or refugee status are also often excluded from services to support healthy development and learning. This chapter presents a process-oriented developmental framework to guide the development and evaluation of interventions that can buffer the effects of social and political upheaval, displacement, and refugee and unauthorized status on children and youth's development. Rigorous evaluations, showing how programs mitigate the risks of displacement or refugee or unauthorized status, could yield great benefits for the fields of humanitarian aid and refugee and migration policy, making the relative dearth of such evidence even more stunning. This chapter reviews the existing literature from rigorous evaluations of interventions to address these issues, discusses the challenge of measurement of risk and protective factors in these contexts with particular sensitivity to cultural variation, as well as how to address cultural factors in the development and evaluation of interventions. The chapter concludes with specific methodological recommendations for a sound research agenda to further improve our understanding of risk and resilience in development of children and youth affected by war, displacement, and refugee or unauthorized status.

Sign in / Sign up

Export Citation Format

Share Document