scholarly journals Serum antioxidant status and mortality from influenza and pneumonia in US adults

2022 ◽  
pp. 1-25
Author(s):  
Habyeong Kang ◽  
Howard Hu ◽  
Sung Kyun Park
Keyword(s):  
Vitamin C ◽  
Antioxidant Status ◽  
Influenza Infection ◽  
Serum Vitamin ◽  
Nhanes Iii ◽  
Serum Concentrations ◽  
The Us ◽  
Total Antioxidant ◽  
Influenza Pneumonia ◽  
Β Carotene

Abstract Objective: We examined the association between serum antioxidant status and mortality from influenza and pneumonia in US adults. Design: Serum concentrations of antioxidants included vitamin C, vitamin A, vitamin E, sum of α- and β-carotene, β-cryptoxanthin, lutein+zeaxanthin, and lycopene. We computed total antioxidant capacity (TAC) as a measure of composite antioxidant status in serum. Survey-weighted Cox proportional hazard models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) comparing quartiles of each antioxidant and TAC. Setting: Data from the US National Health and Nutrition Examination Survey (NHANES)-III. Participants: A total of 7428 NHANES-III participants ≥45 years of age. Results: With a weighted-median follow-up of 16.8 years, 154 participants died from influenza/pneumonia. After adjustment for covariates, serum vitamin C, the sum of α- and β-carotene, and TAC were non-linearly associated with influenza/pneumonia mortality, with the statistically significant smallest HRs at the third quartile vs the first quartile [HRs=0.38 (95% CI: 0.19–0.77), 0.29 (0.16–0.51), and 0.30 (0.15–0.59), respectively]. HRs comparing the fourth vs the first quartiles were weaker and non-significant: 0.57 (95% CI: 0.27–1.17), 0.70 (0.41–1.19), and 0.65 (0.31–1.35), respectively. Serum lycopene had a monotonic association with influenza/pneumonia mortality [HR=0.43 (95% CI: 0.23–0.83) comparing the fourth vs the first quartile, P-for-trend=0.01]. Conclusions: The present study suggests that antioxidant intake as reflected by serum concentrations may reduce mortality risk from influenza or pneumonia in the US general population. These findings warrant further confirmation in other populations with different settings (e.g., a shorter-term association with influenza infection).

scholarly journals Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?

2005 ◽  
Vol 94 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Pilar Galan ◽  
Serge Briançon ◽  
Alain Favier ◽  
Sandrine Bertrais ◽  
Paul Preziosi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Serum Concentrations ◽  
Antioxidant Supplementation ◽  
Baseline Serum ◽  
Men And Women ◽  
Risk Of Cancer ◽  
The Impact ◽  
Β Carotene

The SUpplementation en VItamines et Mineraux AntioXydants (SU.VI.MAX) study, a randomised double-blind, primary-prevention trial showed that after 7·5 years, low-dose antioxidant supplementation lowered the total cancer incidence in men, but not in women. To explain this difference in the impact of antioxidant supplementation in men and women, we hypothesised that the effect of supplementation is dependent on initial antioxidant status; 12 741 French adults (7713 females aged 35–60 years; 5028 males aged 45–60 years) received daily antioxidant supplementation (120 mg vitamin C, 30 mg vitamin E, 6 mg β-carotene, 100 μg Se, 20 mg Zn daily) or a matching placebo. Cut-off limits for baseline serum concentrations of the different antioxidant vitamins and minerals were defined as follows for both men and women: 0·3 μmol/l for β-carotene, 11·4 μmol/l for vitamin C, 15 μmol/l for vitamin E, 0·75 μmol/l for Se and 10·7 μmol/l for Zn. The percentage of men with serum concentrations under cut-off limits was higher for vitamins C and E and β-carotene in those who developed a cancer than in those who did not. The risk of cancer was higher in men with baseline concentrations of serum vitamin C or vitamin E under cut-off limits, but not in women. The effect of supplementation was greater in men with baseline serum concentrations of vitamin C, vitamin E and β-carotene below the cut-off limits compared with those above it. This effect was maintained only for vitamin E after adjustment for age, tobacco, and alcohol consumption and BMI. No effect of supplementation could be seen in women. Baseline antioxidant status is related to the risk of cancer in men but not in women and therefore does not entirely explain the differences observed in the effect of antioxidant supplementation on cancer risk between sexes in the SU.VI.MAX study.

Antioxidant Status, Oxidative Stress, and Damage in Elite Trained Kayakers and Canoeists and Sedentary Controls

2009 ◽  
Vol 19 (5) ◽  
pp. 443-456 ◽  
Author(s):  
Vitor Teixeira ◽  
Hugo Valente ◽  
Susana Casal ◽  
Franklim Marques ◽  
Pedro Moreira
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Antioxidant Defense System ◽  
Strenuous Exercise ◽  
Antioxidant Intake ◽  
Total Antioxidant ◽  
Β Carotene

Strenuous physical activity is known to generate reactive oxygen species to a point that can exceed the antioxidant defense system and lead to oxidative stress. Dietary intake of antioxidants, plasma enzymatic (superoxide dismutase, glutathione reductase [Gr], and glutathione peroxidase [GPx]) activities, nonenzymatic (total antioxidant status [TAS], uric acid, α-tocopherol, retinol, α-carotene, β-carotene, lycopene, and lutein + zeaxanthin) antioxidants, and markers of lipid peroxidation (thiobarbituricacid-reactive substances [TBARS]) and muscle damage (creatine kinase [CK]) were measured in 17 elite male kayakers and canoeists under resting conditions and in an equal number of age- and sex-matched sedentary individuals. Athletes showed increased plasma values of α-tocopherol (p = .037), α-carotene (p = .003), β-carotene (p = .007), and superoxide dismutase activity (p = .002) and a lower TAS level (p = .030). Antioxidant intake (α-tocopherol, vitamin C, and β-carotene) and plasmatic GPx, Gr, lycopene, lutein + zeaxanthin, retinol, and uric acid levels were similar in both groups. Nevertheless, TBARS (p < .001) and CK (p = .011) levels were found to be significantly higher in the kayakers and canoeists. This work suggests that despite the enhanced levels of antioxidants, athletes undergoing regular strenuous exercise exhibited more oxidative stress than sedentary controls.

Effects of β-carotene, vitamin C and E on antioxidant status in hyperlipidemic smokers

2002 ◽  
Vol 13 (7) ◽  
pp. 427-434 ◽  
Author(s):  
Jane C.-J Chao ◽  
Chiung-Hui Huang ◽  
Shu-Ju Wu ◽  
Suh Ching Yang ◽  
Nen-Chung Chang ◽  
...  
Keyword(s):  
Vitamin C ◽  
Antioxidant Status ◽  
Β Carotene

scholarly journals Plasma and Salivary Non-Urate Total Antioxidant Capacity Does Not Depend on Dietary Vitamin C, E, or β-Carotene Intake in Older Subjects

Molecules ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 983 ◽  
Author(s):  
Anna Gawron-Skarbek ◽  
Agnieszka Guligowska ◽  
Anna Prymont-Przymińska ◽  
Dariusz Nowak ◽  
Tomasz Kostka
Keyword(s):  
Vitamin C ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Dietary Vitamin ◽  
Total Antioxidant ◽  
Older Subjects ◽  
Β Carotene

scholarly journals The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

2020 ◽  
Author(s):  
Aida Torkzaban ◽  
Seyed Amir Mansour Alavi Naeini ◽  
Akbar Hassanzadeh ◽  
Mehrdad Namdari
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Case Control Study ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Case Control ◽  
Significant Difference ◽  
Control Study

Abstract Background: Coronary Heart Disease (CHD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. The aim of this study is to measure the serum level of UA and vitamin C as well as the antioxidant status of CHD patients to evaluate their relationship and compare them with the healthy individual.Materials and methods: The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. Food frequency questionnaire (FFQ) and international physical activity questionnaire were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid (UA), vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results: A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C intake (P<0.047). A significant relationship was also observed between the systolic blood pressure and CHD (P<0.028).Conclusion: Our results suggest that increasing of serum uric acid and a decrease in serum vitamin C level can be considered as risk factors for CHD patients. Due to the lack of significant correlation between TAC and CHD in this study, it seems that different results will be obtained with increasing sample size.

scholarly journals Assessment of Vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2956 ◽  
Author(s):  
Gaetano Isola ◽  
Alessandro Polizzi ◽  
Simone Muraglie ◽  
Rosalia Leonardi ◽  
Antonino Lo Giudice
Keyword(s):  
Heart Disease ◽  
Vitamin C ◽  
Ischemic Heart Disease ◽  
Serum Vitamin ◽  
Multivariate Model ◽  
Ischemic Heart ◽  
Reactive Protein ◽  
Gingival Health ◽  
Hs Crp ◽  
Β Carotene

Vitamin C and antioxidants play a crucial role in endothelial function and may be a link for the known interaction of periodontitis and ischemic heart disease (CAD). This pilot study evaluates the association of gingival health, periodontitis, CAD, or both conditions with salivary and serum vitamin C and antioxidant levels. The clinical and periodontal characteristics, serum, and saliva samples were collected from 36 patients with periodontitis, 35 patients with CAD, 36 patients with periodontitis plus CAD, and 36 healthy controls. Levels of vitamin C, antioxidants, and C-reactive protein (hs-CRP) were assessed with a commercially available kit. The median concentrations of salivary and serum vitamin C and antioxidants (α-tocopherol, β-carotene, lutein, and lycopene) were significantly lower in the CAD group (p < 0.001) and in the periodontitis plus CAD group (p < 0.001) compared to periodontitis patients and controls. In univariate models, periodontitis (p = 0.034), CAD (p < 0.001), and hs-CRP (p < 0.001) were significantly negatively associated with serum vitamin C; whereas, in a multivariate model, only hs-CRP remained a significant predictor of serum vitamin C (p < 0.001). In a multivariate model, the significant predictors of salivary vitamin C levels were triglycerides (p = 0.028) and hs-CRP (p < 0.001). Patients with CAD and periodontitis plus CAD presented lower levels of salivary and serum vitamin C compared to healthy subjects and periodontitis patients. hs-CRP was a significant predictor of decreased salivary and serum vitamin C levels.

scholarly journals Associations of serum carotenoid concentrations and fruit or vegetable consumption with serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 concentrations in the Third National Health and Nutrition Examination Survey (NHANES III)

2016 ◽  
Vol 5 ◽  
Author(s):  
Anja Diener ◽  
Sabine Rohrmann
Keyword(s):  
Fruits And Vegetables ◽  
Molar Ratio ◽  
Nhanes Iii ◽  
Serum Concentrations ◽  
Health And Nutrition ◽  
Igf System ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Β Carotene ◽  
Igfbp 3

AbstractDietary intervention may alter the insulin-like growth factor (IGF) system and thereby cancer risk. In a qualitative review, eleven of twenty studies showed a link between one or more carotenoids, vegetable or fruit intake and the IGF system, however, with partly contrary findings, such that no firm conclusion can be drawn. Therefore, we evaluated associations between serum carotenoid concentrations or the intake of fruits and vegetables with IGF-1, IGF binding protein (BP)-3 and their molar ratio (IGF-1:IGFBP-3) within the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). In our analysis, we included 6061 NHANES III participants and used multivariable-adjusted linear regression models. IGF-1 concentrations were significantly positively associated with serum concentrations of lycopene, β-carotene, α-carotene, β-cryptoxanthin and lutein/zeaxanthin in men and women. Statistically significant positive associations were observed for serum concentrations of α-carotene and lutein/zeaxanthin and intake of fruits with serum IGFBP-3 concentrations in women, but not in men. The IGF-1:IGFBP-3 molar ratio was significantly positively associated with serum concentrations of lycopene, β-carotene and α-carotene in men and with β-carotene in women. In conclusion, dietary interventions with carotenoids, fruits and vegetables may affect the IGF system, although the direction of these effects is currently unclear.

Evaluation of trace elements, oxidant/antioxidant status, vitamin C and β-carotene in dogs with dermatophytosis

Mycoses ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
S. A. Beigh ◽  
J. S. Soodan ◽  
R. Singh ◽  
A. M. Khan ◽  
M. A. Dar
Keyword(s):  
Trace Elements ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Β Carotene

scholarly journals Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries

2001 ◽  
Vol 85 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Begoña Olmedilla ◽  
Fernando Granado ◽  
Susan Southon ◽  
Anthony J. A. Wright ◽  
Inmaculada Blanco ◽  
...  
Keyword(s):  
Northern Ireland ◽  
The Netherlands ◽  
Vitamin C ◽  
European Countries ◽  
Provitamin A ◽  
Plasma Vitamin ◽  
Serum Concentrations ◽  
Blood Concentrations ◽  
Republic Of Ireland ◽  
Β Carotene

High intakes of fruits and vegetables, or high circulating levels of their biomarkers (carotenoids, vitamins C and E), have been associated with a relatively low incidence of cardiovascular disease, cataract and cancer. Exposure to a high fruit and vegetable diet increases antioxidant concentrations in blood and body tissues, and potentially protects against oxidative damage to cells and tissues. This paper describes blood concentrations of carotenoids, tocopherols, ascorbic acid and retinol in well-defined groups of healthy, non-smokers, aged 25–45 years, 175 men and 174 women from five European countries (France, UK (Northern Ireland), Republic of Ireland, The Netherlands and Spain). Analysis was centralised and performed within 18 months. Within-gender, vitamin C showed no significant differences between centres. Females in France, Republic of Ireland and Spain had significantly higher plasma vitamin C concentrations than their male counterparts. Serum retinol and α-tocopherol levels were similar between centres, but γ-tocopherol showed a great variability being the lowest in Spain and France, and the highest in The Netherlands. The provitamin A: non-provitamin A carotenoid ratio was similar among countries, whereas the xanthophylls (lutein, zeaxanthin, β-cryptoxanthin) to carotenes (α-carotene, β-carotene, lycopene) ratio was double in southern (Spain) compared to the northern areas (Northern Ireland and Republic of Ireland). Serum concentrations of lutein and zeaxanthin were highest in France and Spain; β-cryptoxanthin was highest in Spain and The Netherlands;trans-lycopene tended to be highest in Irish males and lowest in Spanish males; α-carotene and β-carotene were higher in the French volunteers. Due to the study design, the concentrations of carotenoids and vitamins A, C and E represent physiological ranges achievable by dietary means and may be considered as ‘reference values’ in serum of healthy, non-smoking middle-aged subjects from five European countries. The results suggest that lutein (and zeaxanthin), β-cryptoxanthin, total xanthophylls and γ-tocopherol (and α- : γ-tocopherol) may be important markers related to the healthy or protective effects of the Mediterranean-like diet.

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