Mixed Synapses as a Testbed for Developing Reagents for Building Connectomes and Synaptomes

2012 ◽  
Vol 18 (S2) ◽  
pp. 624-625
Author(s):  
E. Rosa-Molinar
Keyword(s):  
Mixed Synapses

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

Plasticity of gap junctions at mixed synapses

Gap Junctions ◽  
1993 ◽  
pp. 135-139 ◽  
Author(s):  
D.S. FABER ◽  
X.-D. YANG ◽  
L.R. WOLSZON
Keyword(s):  
Gap Junctions ◽  
Mixed Synapses

scholarly journals Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell

2015 ◽  
Vol 114 (1) ◽  
pp. 689-697 ◽  
Author(s):  
Roger Cachope ◽  
Alberto E. Pereda
Keyword(s):  
Opioid Receptors ◽  
Mammalian Brain ◽  
Mu Opioid Receptors ◽  
Electrical Transmission ◽  
Electrical Synapses ◽  
Mu Opioid ◽  
Mauthner Cell ◽  
Connexin 36 ◽  
Mixed Synapses ◽  
Lateral Dendrite

Opioid receptors were shown to modulate a variety of cellular processes in the vertebrate central nervous system, including synaptic transmission. While the effects of opioid receptors on chemically mediated transmission have been extensively investigated, little is known of their actions on gap junction-mediated electrical synapses. Here we report that pharmacological activation of mu-opioid receptors led to a long-term enhancement of electrical (and glutamatergic) transmission at identifiable mixed synapses on the goldfish Mauthner cells. The effect also required activation of both dopamine D1/5 receptors and postsynaptic cAMP-dependent protein kinase A, suggesting that opioid-evoked actions are mediated indirectly via the release of dopamine from varicosities known to be located in the vicinity of the synaptic contacts. Moreover, inhibitory inputs situated in the immediate vicinity of these excitatory synapses on the lateral dendrite of the Mauthner cell were not affected by activation of mu-opioid receptors, indicating that their actions are restricted to electrical and glutamatergic transmissions co-existing at mixed contacts. Thus, as their chemical counterparts, electrical synapses can be a target for the modulatory actions of the opioid system. Because gap junctions at these mixed synapses are formed by fish homologs of the neuronal connexin 36, which is widespread in mammalian brain, it is likely that this regulatory property applies to electrical synapses elsewhere as well.

scholarly journals Variability of Distribution of Ca2+/Calmodulin-Dependent Kinase II at Mixed Synapses on the Mauthner Cell: Colocalization and Association with Connexin 35

2010 ◽  
Vol 30 (28) ◽  
pp. 9488-9499 ◽  
Author(s):  
C. E. Flores ◽  
R. Cachope ◽  
S. Nannapaneni ◽  
S. Ene ◽  
A. C. Nairn ◽  
...  
Keyword(s):  
Mauthner Cell ◽  
Mixed Synapses
Sign in / Sign up

Export Citation Format

Share Document