scholarly journals Seasonal influenza among children diagnosed by their guardians: a small pilot study in Japan

Author(s):  
Hiroki Maita ◽  
Tadashi Kobayashi ◽  
Hiroshi Osawa ◽  
Hiroyuki Kato

AbstractAimWe aimed to elucidate the accuracy and optimal cut-off point of the self-diagnosis of influenza and the associated clinical symptoms of children by their guardians, compared with those of the rapid influenza diagnostic test (RIDT).BackgroundSeasonal influenza is a common outpatient problem during the winter season. A paediatric influenza epidemic has socio-economic impacts like temporary school closure, school event cancellations, and unscheduled work absences among parents. Hence, early identification and assessment of influenza to prevent its spread is important from a societal perspective.MethodWe performed a cross-sectional observational study in a rural clinic in Japan every winter season from December 2013 to March 2016. We retrospectively extracted information from the medical records and pre-examination checklists of 24 patients aged <12 years (mean age, 5.4 years; men, 54.2%). The data extracted from the medical records and pre-examination checklist included the baseline characteristics (age, sex and past medical history of influenza), clinical signs and symptoms, diagnosis by guardians (%) and RIDT results.FindingsThe optimal cut-off point of the self-diagnosis of influenza by guardians was 80%, with a sensitivity and specificity of 63.6% (95% confidence interval: 30.8–89.1) and 92.3% (64.0–99.8). At a 50% cut-off point, the sensitivity and specificity were 90.9% (58.7–99.8) and 53.8% (25.1−80.8). The accuracy of feeling severely sick, as estimated by the guardians showed a sensitivity and specificity of 90.9% (58.7–99.8) and 69.2% (38.6–90.9). Our study indicates that the diagnosis of seasonal influenza by guardians to their children would be useful in the establishment of both confirmatory diagnoses when it has high probability above the optimal cut-off point (80%), and exclusion diagnosis when it has low probability (50%). Not feeling severely sick, estimated by the guardians might be a useful indicator for the exclusion of paediatric influenza.

2020 ◽  
Vol 24 (2) ◽  
pp. 244-249
Author(s):  
V.Yu. Pasik

Annotation. Respiratory diseases are relevant in pediatric practice, which is associated with its widespread and frequent complications, especially in young children. The aim of the study was to assess the diagnostic value of clinical symptoms, laboratory and ultra-sonographic parameters in pneumonia in children of the first 3 years of life. A retrospective study of medical records of 218 children who were hospitalized in the department for young children diagnosed with pneumonia for the period from 2016 to 2018. The average age of children was 11.67±9.97 months and it was within the range from 1 month to 3 years. The ration of boys and girls was practically identical (51.8% and 48.2% accordingly). The first group included children aged under one year (the average age is 4.57±0.84 months; n=88). The second group included children aged from 1 to 3 years (the average age is 18.2±4.25 months; n=130). To characterize the information content of clinical and laboratory symptoms the study has used objective parameters defined as the operational characteristics of tests. The most important operational characteristics of diagnostic methods included: sensitivity (Se, sensitivity) and specificity (Sp, specificity). To check the statistical hypothesis on differences of absolute and relative frequencies, fractions, and ratios in two independent samples, the criteria of хі-square (χ2) was used. While detailing an anamnesis, the disease was more often related to untimely treatment and outpatient care. Various data were obtained on the absolute and relative risk, as well as the sensitivity and specificity of the localization of pneumonia depending on age. Therefore, the incidence of bilateral pneumonia was considered an indicator of risk. On admission to hospital, the body temperature of patients was 38.2±0.66°С. Most of the complaints were on the unproductive or productive cough. Besides, in some cases, shortness of breath and runny nose were mentioned. Thus, in young children with pneumonia, a diagnostically significant clinical symptom is a bilateral lung impression (82.6%), compared with right-handed (15.1%) and left-handed (2.3%), which is significantly more common in children under 1-th year of life compared with patients 1–3 years; laboratory features are probably higher levels of liver-specific enzymes – ALT and AST in children under 1 year; ultrasonographic indicators associated with the presence of pneumonia in young children include increased liver size, gallbladder deformity, the presence of sediment in the gallbladder, dyskinesia of the biliary tract, thickening of the gallbladder wall; children under 1 year of age have a risk of liver enlargement and biliary dyskinesia.


2020 ◽  
Vol 14 (12) ◽  
pp. e0008917
Author(s):  
Fred Bernardes Filho ◽  
Jaci Maria Santana ◽  
Regina Coeli Palma de Almeida ◽  
Glauber Voltan ◽  
Natália Aparecida de Paula ◽  
...  

Background This study evaluates an active search strategy for leprosy diagnosis based on responses to a Leprosy Suspicion Questionnaire (LSQ), and analyzing the clinical, immunoepidemiological and follow-up aspects for individuals living in a prison population. Methods A cross-sectional study based on a questionnaire posing 14 questions about leprosy symptoms and signs that was distributed to 1,400 prisoners. This was followed by dermatoneurological examination, anti-PGL-I serology and RLEP-PCR. Those without leprosy were placed in the Non-leprosy Group (NLG, n = 1,216) and those diagnosed with clinical symptoms of leprosy were placed in the Leprosy Group (LG, n = 34). Findings In total, 896 LSQ were returned (64%), and 187 (20.9%) of the responses were deemed as positive for signs/symptoms, answering 2.7 questions on average. Clinically, 1,250 (89.3%) of the prisoners were evaluated resulting in the diagnosis of 34 new cases (LG), based on well-accepted clinical signs and symptoms, a new case detection rate of 2.7% within this population, while the NLG were comprised of 1,216 individuals. The confinement time medians were 39 months in the LG while it was 36 months in the NLG (p>0.05). The 31 leprosy cases who responded to the questionnaire (LSQ+) had an average of 1.5 responses. The symptoms “anesthetized skin area” and “pain in nerves” were most commonly mentioned in the LG while “tingling, numbness in the hands/feet”, “sensation of pricks and needles”, “pain in nerves” and “spots on the skin” responses were found in more than 30% of questionnaires in the NLG. Clinically, 88.2% had dysesthetic macular skin lesions and 97.1% presented some peripheral nerve impairment, 71.9% with some degree of disability. All cases were multibacillary, confirming a late diagnosis. Anti-PGL-I results in the LG were higher than in the NLG (p<0.0001), while the RLEP-PCR was positive in 11.8% of the patients. Interpretation Our findings within the penitentiary demonstrated a hidden prevalence of leprosy, although the individuals diagnosed were likely infected while living in their former communities and not as a result of exposure in the prison. The LSQ proved to be an important screening tool to help identify leprosy cases in prisons.


2021 ◽  
Vol 62 (2) ◽  
Author(s):  
Đặng Quang Phúc ◽  
Đỗ Văn Mãi ◽  
Hoàng Đức Thái ◽  
Bùi Đặng Minh Trí

  Objective: To describe the current situation of using drugs to treat gout on inpatients at Can Tho City General Hospital. Subjects and methods: Retrospective, cross-sectional, descriptive, non-intervention study based on inpatient medical records for gout treatment at Can Tho City General Hospital with admission time from June 2019 to December 2019. Results: The majority of patients were prescribed colchicine, accounting for 91.35%, followed by oral and injected meloxicam, with 55.77.0% and 29.81% respectively. Inpatients using a single regimen mainly used paracetamol (accounting for 36.11%) and colchicine (accounting for 22.22%). The most commonly used 2-drug inpatient regimen included: colchicin + oral paracetamol (30.43%), oral meloxicam + oral paracatamol (19.57%). The 3-drug combination regimen on the inpatient group includes: colchicin + injected meloxicam + oral paracetamol (accounting for 61.11%). The four-drug combination regimen was colchicin + injected meloxicam + oral methylprednisolon + infused paracetamol. The majority of inpatients had the regimen changed due to improved clinical symptoms (accounting for 64.13%). Approximately 25.54% of patients need changes due to more severe clinical symptoms. Only 6 medical records showed adverse events during the treatment process, accounting for 5.77%. In which, digestive disorders accounted for the highest percentage with 50.0%. Conclusion: Gout inpatients were mainly indicated for the use of colchicin and meloxicam. The main regimens used in monotherapy were paracetamol and colchicin, the multitherapy regimen mainly used colchicin, meloxicam and paracetamol. Drug side effects were low at 5.77%.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daryoosh Fahimi ◽  
Leila Khedmat ◽  
Azadeh Afshin ◽  
Zahra Noparast ◽  
Maryam Jafaripor ◽  
...  

Abstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics. Methods A cross-sectional study with 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012–2018 was conducted. The ultrasound examination of kidneys and urinary tract during hospitalization, the incidence of clinical symptoms, and laboratory markers in blood and urine were monitored to identify the best predictive factors of early diagnosis of this bacterial infection. Results Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, and vomiting, while others were asymptomatic. A much frequency of pyuria (88.46%), Escherichia coli in urine (92.31%), leukocytosis (81.73%), and high ESR (> 10 mm/h, 92.30%) and CRP (> 10 mg/L, 82.82%) was observed. The kidney and urinary tract ultrasonography only in 32.7% of children revealed findings in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis). Conclusion There was a high frequency of clinical signs and laboratory markers associated with pyelonephritis. Ultrasound alone was not an efficient tool to track febrile UTI as most patients presented normal sonography.


2016 ◽  
Vol 29 (6) ◽  
pp. 389
Author(s):  
Emanuel Castro Cassoco Catumbela ◽  
Cristina Santos ◽  
Alberto Freitas ◽  
Carlos Costa ◽  
António Sarmento ◽  
...  

<p><strong>Introduction:</strong> After conducting a systematic review of quality indicators for assessing HIV/AIDS clinical care, we aimed to assess the clinical relevance and practice utility of those indicators from the point of view of HIV/AIDS physician experts.<br /><strong>Material and Methods:</strong> This is an observational, cross-sectional study, in which we selected, by convenience, physicians who work in an Infectious Disease Department of a central hospital to complete two questionnaires with a core set of indicators to establish the most relevant and useful indicators for assessment of the clinical HIV/AIDS care. A Likert scale was used to rank the indicators.<br /><strong>Results:</strong> Eleven of thirteen physicians filled two questionnaires. From the initial list of 53 quality indicators, 21 were identified as the most relevant and useful in HIV/AIDS clinical care. The internal consistency for clinical relevance in each indicators domain was for clinical signs and symptoms (<em>p</em> = 0.971), for therapy (<em>p</em> = 0.900), for prognosis (<em>p</em> = 0.820) and diagnosis (<em>p</em> = 0.733) and for practice utility were diagnosis (<em>p</em> = 0.934), clinical signs (<em>p</em> = 0.964), laboratory examinations (<em>p</em> = 0.947), therapy (<em>p</em> = 0.583) and prognosis (<em>p</em> = 0.368).<br /><strong>Discussion:</strong> In the process of assessing the clinical relevance and practice utility of HIV/AIDS quality care indicators, it was found that the majority of physicians agreed that diagnosis and clinical symptoms and signs indicators domains are the most important for assessing the quality of care for HIV/AIDS patients.<br /><strong>Conclusion:</strong> This instrument should be considered as a diagnostic tool, allowing hospital administrators to identify if HIV/AIDS care is properly delivered or needs improvement.</p>


2008 ◽  
Vol 2 (5) ◽  
pp. 210
Author(s):  
Lambok Siahaan ◽  
Titik Yuniarti

Bencana tsunami melanda Nanggroe Aceh Darussalam pada tanggal 26 Desember 2004, selain meningkatkan kejadian luar biasa (KLB) malaria juga memunculkan daerah-daerah endemis malaria. Penelitian ini dilakukan untuk mendapatkan prevalensi penderita malaria di Pulau Weh, pasca Tsunami pada akhir 2004. Penelitian dilakukan secara ‘cross sectional’. Diagnostik malaria ditegakkan berdasarkan pemeriksaan apusan darah (mikroskopik). Ditemukan penurunan kasus malaria di Pulau Weh. Prevalensi penderita malaria yang diperoleh adalah 15,3%. Dari semua penderita malaria, 41,4% tanpa gejala klinis demam. Penderita yang tidak mengalami gejala klinis demam tersebut, umumnya mempunyai gejala klinis badan pegal, pusing, gangguan pencernaan danlemas. Penurunan prevalensi malaria dalam penelitian ini dapat saja terjadi oleh karena perbedaan cara dalam menetapkan diagnosa dan waktu pengambilan data yang tidak dilakukan pada “musim malaria”.Kata kunci: Malaria klinis, gejala klinis, tanda klinis.AbstractTsunami disaster that occured in Nanggroe Aceh Darussalam on 26 December 2004, has increased malaria outbreak and emerged new malaria endemic areas. The study was conducted to obtain malaria prevalence after tsunami in Weh island. The design used in this study is cross-sectional. Malaria was diagnosed through blood examination (microscopic). The study found reducing malaria cases in Weh Island. The prevalence of malaria in this study was 15.3%. Among all malaria patients, there were 41.4% who did not get fever. Those without fever, usually suffered from myalgia, headache. Abdominal discomfort and weakness. The decrease malaria prevalence in this study could be caused by either differences in diagnostic method or timing of data collection.Key words: Clinical malaria, clinical signs, clinical symptoms.


2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Octavianus Giovani ◽  
Hasrayati Agustina ◽  
Teguh M Djajakusumah

Mediastinal tumors are considered to be mediastinal disease with various clinical and histopathologic presentations. In Indonesia, literatures concerning mediastinal tumors are still few. This study aims to obtain the characteristic of mediastinal tumors in Dr.Hasan Sadikin Hospital. A cross-sectional retrospective study was conducted using medical records from 2011 to 2016. All medical records with clinical diagnosis of mediastinal tumors are included, and cases with metastatic tumors from distant sites to the mediastinum, and/or incorrect histopathologic findings are excluded. We obtain data of age, gender, clinical symptoms, histopathologic finding, and staging, with total samples collected of 72. We find out that patients with mediastinal tumors are mainly over 40 years old (62.5%), especially in the 6th decade of life (23.6%), and were mostly of males (73.6%). Patients mainly had chief complaints of dyspnea (38.7%), followed by cough and typical myasthenia gravis symptoms. The most common type of mediastinal tumor is epithelial cell tumor (68.4%), and the most common stage is Masaoka-Koga stage III (37.5%). This study concludes that mediastinal tumor mainly occurs in males aged 40 years old and above, with epithelial cell tumor as the most common histopathologic findings.Keywords : characteristics; mediastinal tumor; mediastinum


Author(s):  
Aryati Aryati ◽  
Dwi Retno Pawarti ◽  
Izzuki Muhashonah ◽  
Janti Tri Habsari

Allergic rhinitis is an allergic disease that is most often found beside bronchial asthma and eczema with the prevalence of is about 33.3%, 9.8% and 11.2% respectively. The main examinations of allergic rhinitis are Skin Prick Test (SPT) and specific IgE, becausethe sensitivity and specificity of specific IgE examination depend on the examination method. To know the diagnostic value of specific IgE immunoblot examination by determination and were compared with ELISA in patients with allergic rhinitis. The cross-sectional design of the study is con-ducted on patients at the Outpatient Clinic Department of ENT-Head and Neck from May until October 2014. Patients were grouped as diagnosis of allergic rhinitis and non-allergic non-infectious rhinitis based on clinical signs and symptoms, physical examina-tion, positive in SPT examination with or without an increase in total serum IgE and/or blood eosinophils. Specific IgE immunoblot was conducted by using Foresight®, Acon Laboratories and the ELISA method using Allercoat™. The sensitivity and specificity of inhalant allergen -specific IgE immunoblot Foresight® method was 73.9% and 42.9%, respectively. The sensitivity and specificity of inhalant allergen -specific IgE ELISA method was 67.4% and 57.1%, respectively. The results of these two methods have a correlation coefficient 0.531 with p=0.000. The sensitivity and specificity of ingestan allergen specific IgE immunoblot Foresight® method was 41.3% and 85.7%, respectively. The sensitivity and specificity of ingestan allergen specific IgE ELISA method was 17.4 and 78.6%, res-pectively. Results of these two methods have a correlation coefficient 0.375 with p=0.003. Based on this study of specific IgE immunoblot and ELISA methods, both have diagnostic sensitivity and specificity, which are almost the same. The sensitivity of immunoblot method inhalant allergens are superior to ELISA. The Immunoblot method ingestan allergen specificity is superior to ELISA.


2016 ◽  
Vol 68 (5) ◽  
pp. 1105-1111
Author(s):  
A.C. Nepomuceno ◽  
R. Zanatta ◽  
D.G. Chung ◽  
P.F. Costa ◽  
M.A.R. Feliciano ◽  
...  

ABSTRACT Computed tomography of the brain is necessary as part of the diagnosis of lesions of the central nervous system. In this study we used six domestic cats, male or female, aged between one and five years, evaluated by Computed Tomography (CT) examination without clinical signs of central nervous system disorders. Two euthanized animals stating a condition unrelated to the nervous system were incorporated into this study. The proposal consisted in establishing detailed anatomical description of tomographic images of normal brain of cats, using as reference anatomical images of cross sections of the stained brain and cranial part, with thicknesses similar to the planes of the CT images. CT examinations were performed with and without intravenous iodinated contrast media for live animals. With one euthanized animal, the brain was removed and immediately preserved in 10% formalin for later achievement in cross-sectional thickness of approximately 4mm and staining technique of Barnard, and Robert Brown. The head of another animal was disarticulated in the Atlanto-occipital region and frozen at -20ºC then sliced to a thickness of about 5mm. The description of visualized anatomical structures using tomography is useful as a guide and allows transcribing with relative accuracy the brain region affected by an injury, and thus correlating it with the clinical symptoms of the patient, providing additional information and consequent improvement to veterinarians during the course of surgical clinic in this species.


e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Reynaldo B. Umboh ◽  
Nola T. S. Mallo ◽  
Erwin G. Kristanto

Abstact: Death can be identified by using advanced signs of death as follows: postmortem lividity (livor mortis), rigor mortis, decomposition, mummification, and adipocere. Postmortem lividity occurs right after clinical signs of death. Erythrocytes will accumulate to the lowest area of the body due to gravity, fill the veins and venules, and then form reddish purple spots called lividity. This study aimed to find the effect of hemoglobin level on colors indicating postmortem lividity and the time when the lividity vanishes due to pressure. This study used a cross-sectional design and was carried out at Prof. Dr. R. D. Kandou Hospital Manado from October to December 2015. In this study, pressure was given to the livor mortis of the deceased patients. Hemoglobin levels were obtained from the medical records. The results showed that there was a statistically significant effect of hemoglobin levels on the vanishing time of livor mortis (p<0.05, p=0.040), meanwhile there was no significant effect of hemoglobin levels on the colors indicating livor mortis (constant). Additional samples with more accurate instrument for measuring the differences in colors and periodical documentation with videos are recommended for further studies. Keywords: hemoglobin postmortem lividity (livor mortis) Abstrak: Kematian dapat dikenal pada seseorang melalui adanya tanda-tanda kematian lanjut berupa lebam mayat, kaku mayat, pembusukan, mumifikasi dan adiposera. Lebam mayat (livor mortis) terjadi setelah kematian klinis. Eritrosit akan menempati tempat terbawah akibat gaya gravitasi, mengisi vena dan venula, membentuk bercak warna merah ungu (livide) pada bagian terbawah tubuh. Penelitian ini bertujuan untuk melihat pengaruh kadar hemoglobin terhadap warna lebam mayat dan hilangnya (detik) ketika diberi penekanan. Jenis penelitian potong lintang. Penelitian dilakukan di RSUP Prof. Dr. R. D. Kandou Manado pada bulan Oktober – Desember 2015 dengan mengamati dan menekan lebam mayat pasien meninggal. Data rekam medis pasien ditelusuri untuk melihat kadar hemoglobin. Hasil penelitian menunjukkan terdapat pengaruh kadar hemoglobin terhadap hilangnya lebam mayat pada penekanan (p<0,05 atau p=0,040) dan tidak ada pengaruh kadar hemoglobin terhadap warna lebam mayat (livor mortis) = konstan. Disarankan untuk penelitian selanjutnya agar menggunakan sampel yang lebih banyak dengan penggunaan alat ukur warna maupun alat ukur untuk melakukan penekanan serta melakukan dokumentasi foto ataupun video secara berkala.Kata kunci: hemoglobin, lebam mayat (livor mortis)


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