scholarly journals Twins with Craniosynostosis: An Unidentified Variant/Twin Research: Kangaroo Care for Premature Twins; Developmental Delay in MZ Twins; Osteosarcoma in One Identical Twin; Controversies in Twin Pregnancy Management/Media Reports: Twin and Triplet Olympians; Twin’s Rescue from a Crocodile; Twin Pandas in Japan; Twin Surrogacy; Identical Twins in Pennsylvania

2021 ◽  
pp. 1-6
Author(s):  
Nancy L. Segal
Keyword(s):  
Developmental Delay ◽  
Twin Pair ◽  
Care Program ◽  
Controversial Issues ◽  
Multiple Pregnancies ◽  
Kangaroo Care ◽  
Olympic Athletes ◽  
Early Closure ◽  
Media Reports ◽  
Mz Twins

Abstract Craniosynostosis involves the early closure of one or more joints connecting the bones of an infant’s skull. A case of young monozygotic (MZ) male twins with an unidentified variant of this condition is described, followed by a summary of relevant published reports. This overview is followed by descriptions of a kangaroo care program for premature twins, developmental delay in an MZ twin pair, osteosarcoma in one MZ twin and controversial issues in the management of multiple pregnancies. Media reports of twin and triplet Olympic athletes, a twin’s rescue from a crocodile, the birth of twin pandas in Japan, a case of twin surrogacy and the birth of identical triplets are also presented.

scholarly journals Oliver Sacks: Our Correspondence About Twins/Twin Research: Vanishing Twins Syndrome; Discordant Sex in MZ Twins; Pregnancy Outcomes in IVF and ICSI Conceived Twins/Print and Media: Superfetated Twins; Twins Discordant for Smoking; Twins in Fashion; Yale University Twin Hockey Players; Conjoined Twin–Visiting Professor

2017 ◽  
Vol 20 (4) ◽  
pp. 363-369
Author(s):  
Nancy L. Segal
Keyword(s):  
New York ◽  
Pregnancy Outcomes ◽  
Twin Pair ◽  
Multiple Pregnancy ◽  
New York Times ◽  
Yale University ◽  
Twin Research ◽  
Hockey Players ◽  
Vanishing Twin Syndrome ◽  
Mz Twins

The late neurologist and author, Oliver Sacks, published an insightful 1986 review of Marjorie Wallace's book, The Silent Twins, in the New York Times. Taking exception to his assertion about Sir Francis Galton, I wrote a letter to the Times’ editor. The letter was unpublished, but it brought a wonderful response from Sacks himself that is reproduced and examined. Next, brief reviews of twin research concerning the vanishing twin syndrome (VTS), discordant sex in a monozygotic (MZ) twin pair, and multiple pregnancy outcomes from assisted reproductive technology (ART) are presented. This section is followed by popular coverage of superfetated twins, smoking-discordant co-twins, twins in fashion, Yale University twin hockey players, and a visiting professor who was a conjoined twin.

Validity of the Zygosity Questionnaire and Characteristics of Zygosity-Misdiagnosed Twin Pairs in the Healthy Twin Study of Korea

2010 ◽  
Vol 13 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Yun-Mi Song ◽  
Dong-Hun Lee ◽  
Mi Kyoung Lee ◽  
Kayoung Lee ◽  
Hee Jung Lee ◽  
...  
Keyword(s):  
Twin Study ◽  
Twin Pair ◽  
Correct Diagnosis ◽  
Striking Similarity ◽  
Genotype Information ◽  
Zygosity Questionnaire ◽  
Questionnaire Method ◽  
Short Tandem Repeat Markers ◽  
Mz Twins ◽  
Short Tandem

AbstractDetermining valid zygosity is a basic and important requirement in a twin study, because misdiagnosing zygosity leads to biased results. The Healthy Twin Study has collected data from adult like-sex twins and their families since 2005. In the study, a questionnaire to determine zygosity was developed comprising four questions; one concerning the degree of resemblance, and three concerning the degree of confusion by the resemblance. Among 2,761 individuals (624 twin pairs) of twin and their families, 406 pairs of twins (mean age 38.3, 63.5% women) with both questionnaire and genotype information were selected to examine the validity of the zygosity questionnaire using 16 short tandem repeat markers. We first determined individual zygosity including undetermined category, and then decided the zygosity of a twin pair using a decision tree. Sensitivity of questionnaire diagnosis was 98.8% for monozygotic (MZ) and 88.9% for dizygotic (DZ) twins, and positive predictive value was 97.2% for MZ and 95.0% for DZ. When we compared correctly and wrongly diagnosed twin pairs, misdiagnosed DZ twins (nine pairs) showed striking similarity in stature or obesity even exceeding that of true MZ twins. Our finding suggests that a parsimonious questionnaire method of diagnosing the zygosity will be useful, and adding physical or physiological measurements to a questionnaire of zygosity diagnosis will either confound the correct diagnosis or reduce the efficiency of the study compared with using questionnaire alone or with introducing genotyping.

scholarly journals The Host Genotype and Environment Affect Strain Types of Bifidobacterium longum subsp. longum Inhabiting the Intestinal Tracts of Twins

2015 ◽  
Vol 81 (14) ◽  
pp. 4774-4781
Author(s):  
Min Zhang ◽  
Xiaomin Hang ◽  
Jing Tan ◽  
Hong Yang
Keyword(s):  
Multilocus Sequence Typing ◽  
Twin Pair ◽  
Bifidobacterium Longum ◽  
Host Genotype ◽  
Content Type ◽  
Living Together ◽  
Adult Twins ◽  
The Impact ◽  
Mz Twins ◽  
Sequence Types

ABSTRACTTo investigate the influences of host genotype and environment onBifidobacterium longumsubsp.longuminhabiting human intestines at the strain level, six pairs of twins, divided into two groups (children and adults), were recruited. Each group consisted of two monozygotic (MZ) twin pairs and one dizygotic (DZ) twin pair. Child twins had been living together from birth, while adult twins had been living separately for 5 to 10 years. A total of 345B. longumsubsp.longumisolates obtained from 60 fecal samples from these twins were analyzed by multilocus sequence typing (MLST), and 35 sequence types (STs) were finally acquired. Comparison of strains within and between the twin pairs showed that no strains with identical STs were observed between unrelated individuals or within adult DZ twin pairs. Eight STs were found to be monophyletic, existing within MZ twins and child DZ twins. The similarity of strain types within child cotwins was significantly higher than that within adult cotwins, which indicated that environment was one of the important determinants inB. longumsubsp.longumstrain types inhabiting human intestines. However, although these differences between MZ and DZ twins were observed, it is still difficult to reach an exact conclusion about the impact of host genotype. This is mainly because of the limited number of subjects tested in the present study and the lack of strain types tracing in the same twin pairs from birth until adulthood.

Concordant tumour of the test in a MZ twin pair

1967 ◽  
Vol 16 (2) ◽  
pp. 172-177 ◽  
Author(s):  
U. Villani
Keyword(s):  
Twin Pair ◽  
Genetic Interpretation ◽  
Mz Twins

SUMMARYThe Author reports the case of two MZ twins concordantly affected by a neoplasm of the testicle. The various etiopathogenetic theories of this form, the data reported in the literature and the genetic interpretation are discussed.

Blood Ties: Chimerism Can Mask Twin Discordance in High-Throughput Sequencing

2011 ◽  
Vol 14 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Yaniv Erlich
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Disease Susceptibility ◽  
Twin Pair ◽  
Twin Studies ◽  
Sequencing Data ◽  
Hematopoietic Stem ◽  
High Throughput Sequencing Data ◽  
Genetic And Environmental Factors ◽  
Mz Twins

Twin studies have long provided a means to separate the contributions of genetic and environmental factors. A recent pioneering report by Baranzini et al. presented an analysis of the complete genomes and epigenomes of a monozygotic (MZ) twin pair discordant for multiple sclerosis. This failed to find any difference between the twins, raising doubts regarding the value of whole-genome twin studies for defining disease susceptibility alleles. However, the study was carried out with DNA extracted from blood. In many cases, the hematopoietic lineages of MZ twins are chimeric due to twin-to-twin exchange of hematopoietic stem cells during embryogenesis. We therefore wondered how chimerism might impact the ability to identify genetic differences. We inferred the blood chimerism rates and profiles of more than 30 discordant twin cases from a wide variety of medical conditions. We found that the genotype compositions of the twins were highly similar. We then benchmarked the performance of SNP callers to detect discordant variations using high-throughput sequencing data. Our analysis revealed that chimerism patterns, well within the range normally observed in MZ twins, greatly reduce the sensitivity of SNP calls. This raises questions regarding any conclusions of genomic homogeneity that might be drawn from studies of blood-derived twin DNA.

Controversial Issues in the Management of Multiple Pregnancies

Twin Research ◽  
2001 ◽  
Vol 4 (3) ◽  
pp. 165-167 ◽  
Author(s):  
Isaac Blickstein
Keyword(s):  
Mode Of Delivery ◽  
Controversial Issues ◽  
Multiple Pregnancies ◽  
Perinatal Medicine ◽  
Genetic Studies ◽  
Special Cases ◽  
Definition Of ◽  
Multifetal Pregnancy ◽  
Selection Of ◽  
Multifetal Pregnancy Reduction

AbstractThe management of multiple pregnancies represents a true challenge for all sub-specialties concerned with perinatal medicine. Many issues were neglected over the years merely because they were rare and therefore considered not sufficiently important to merit clinical trials. This paper discusses a personal selection of controversial issues, such as multifetal pregnancy reduction of triplets and twins, special cases in multifetal preganncy reduction, need for invasive genetic studies, management of twin-twin transfusion, discordant fetal conditions, the definition of “term” in multiples, and the controversy about the mode of delivery.

scholarly journals Application of intraoral scanner to identify monozygotic twins

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Botond Simon ◽  
Laura Lipták ◽  
Klaudia Lipták ◽  
Ádám Domonkos Tárnoki ◽  
Dávid László Tárnoki ◽  
...  
Keyword(s):  
Twin Pair ◽  
Monozygotic Twins ◽  
High Specificity ◽  
Forensic Odontology ◽  
Tolerance Interval ◽  
Intraoral Scanner ◽  
Average Deviation ◽  
The Mean ◽  
Upper Tolerance Limit ◽  
Mz Twins

Abstract Background DNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern of the human palate. Methods The palatal area of 64 MZ twins and 33 same-sex dizygotic (DZ) twins (DZSS) and seven opposite-sex dizygotic twins (DZOS) were scanned three times with an intraoral scanner. From the scanned data, an STL file was created and exported into the GOM Inspect® inspection software. All scans within a twin pair were superimposed on each other. The average deviation between scans of the same subject (intra-subject deviation, ISD) and between scans of the two siblings within a twin pair (intra-twin deviation, ITD) was measured. One-sided tolerance interval covering 99% of the population with 99% confidence was calculated for the ISD (upper limit) and the ITD (lower limit). Results The mean ISD of the palatal scan was 35.3 μm ± 0.78 μm. The calculated upper tolerance limit was 95 μm. The mean ITD of MZ twins (406 μm ± 15 μm) was significantly (p < 0.001) higher than the ISD, and it was significantly lower than the ITD of DZSS twins (594 μm ± 53 μm, p < 0.01) and the ITD of DZOS twins (853 μm ± 202 μm, p < 0.05). Conclusion The reproducibility of palatal intraoral scans proved to be excellent. The morphology of the palate shows differences between members of MZ twins despite their almost identical DNA, indicating that this method could be useful in forensic odontology.

Concordant Glaucoma in MZ Twins

1970 ◽  
Vol 19 (1-2) ◽  
pp. 268-268 ◽  
Author(s):  
L. Gedda ◽  
L. Scullica ◽  
A. Accardi
Keyword(s):  
Twin Pair ◽  
Mz Twins

The Authors report a 54-year-old male MZ twin pair with two single-born relatives suffering from glaucoma.The twins are concordant as to glaucoma, but onset of the disease in the first-born occurred 20 years later than in the second-born. This high chronological difference is ascribed to the hardships the latter twin had suffered for three years in Africa.The meaning of anticipation is discussed in the light of modern views on the time dimensions of the unit of inheritance (chronon).

Aplasia subtotale degli arti superiori in coppia gemellare monozigotica discordante

1963 ◽  
Vol 12 (3) ◽  
pp. 228-237
Author(s):  
L. Gedda ◽  
G. Torrioli-Riggio
Keyword(s):  
Twin Pair ◽  
Fetal Life ◽  
Upper Limbs ◽  
The Individual ◽  
Mz Twins

SUMMARYThe Authors describe a case of aplasia of the upper limbs in a discordant MZ twin pair. According to the individual and genealogical findings, and especially to the fact that these female MZ twins are discordant, as well as to the caryologic finding, the Authors conclude that the malformation is not genetically induced but possibly originated by blastophthoric factors during the first and second month of fetal life.

scholarly journals Twins Separated at Birth: Across a Country and Around the World/Twin Research: Memorial Tribute to Isaac Blickstein, MD; Infanticide and Sacrifice of Archaic-Aged Twins and Triplets; Prehistoric Twin Burials; Highlights from a Conference on Three Identical Strangers/Media Reports: An Atypical Twin Father; An Actor’s Twin Brother; Twin Link to Tulsa, Oklahoma Massacre; Superfetated Twins; Twin Comedians and Script Writers; Indian Twins’ Loss to COVID-19

2021 ◽  
pp. 1-7
Author(s):  
Nancy L. Segal
Keyword(s):  
Final Section ◽  
Twin Pair ◽  
The Other ◽  
Twin Research ◽  
Twin Brother ◽  
Research Section ◽  
The World ◽  
Fresh Perspective ◽  
Media Reports

Abstract Every reared-apart monozygotic (MZ) twin pair offers a fresh perspective on human developmental questions. This is true regardless of whether the co-twins were raised in the same country or across the globe. The members of two pairs of separated MZ female twins have recently come to attention. In one case the twins were raised by different families in Argentina; in the other case the twins were raised by different families in Sweden and Vietnam. The perceptions and perspectives of these twins are insightful. The twin research section that follows begins with a tribute to our late esteemed colleague, Dr Isaac Blickstein (1953−2020). Research concerning the infanticide and sacrifice of Archaic-aged twins and triplets and prehistoric twin burials is reviewed next. Highlights from a conference focused on the 2018 film Three Identical Strangers are also included in this portion. The final section of this article includes media reports of an atypical twin father, an actor’s twin brother, a twin link to the 1921 Tulsa, Oklahoma massacre, the birth of superfetated twins, twin comedians and script writers and Indian twins’ tragic loss to COVID-19.

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