Combined supercritical fluid extraction/solid-phase extraction with octadecylsilane cartridges as a sample preparation technique for the ultratrace analysis of a drug metabolite in plasma

1992 ◽  
Vol 64 (7) ◽  
pp. 802-806 ◽  
Author(s):  
Hanjiu. Liu ◽  
Linda M. Cooper ◽  
Douglas E. Raynie ◽  
J. David. Pinkston ◽  
Kenneth R. Wehmeyer
Keyword(s):  
Sample Preparation ◽  
Solid Phase Extraction ◽  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Solid Phase ◽  
Phase Extraction ◽  
Preparation Technique ◽  
Fluid Extraction ◽  
Ultratrace Analysis ◽  
Sample Preparation Technique

Supercritical Fluid Extraction of N-Nitrosamines in Hams Processed in Elastic Rubber Nettings

1995 ◽  
Vol 78 (3) ◽  
pp. 744-748 ◽  
Author(s):  
John W Pensabene ◽  
Walter Fiddler ◽  
Robert J Maxwell ◽  
Alan R Lightfield ◽  
James W Hampson
Keyword(s):  
Solid Phase Extraction ◽  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Phase Extraction ◽  
Fluid Extraction ◽  
Significant Difference ◽  
Solid Phase Extraction Procedure ◽  
Elastic Rubber

Abstract A method for analysing /V-nitrosamines in hams processed in elastic rubber nettings by supercritical fluid extraction (SFE) is described. The study was carried out with the prototype of a commercial extractor with a silica gel adsorption cartridge integrally attached to the variable restrictor. The SFE method was compared with a solid-phase extraction procedure currently used for ham analysis. Both methods used the same gas chromatographic–chemiluminescence detection conditions. No significant difference (p <0.05) was found between results obtained with the 2 methods. Repeatability standard deviation of the SFE method was 1.7 ppb, with a coefficient of variation (CV) of 2.7%, compared with 2.2 ppb, with a CV of 3.5%, for solid-phase extraction. SFE permits minimal use of solvent and more rapid analysis of nitrosamines.

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