High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity

2018 ◽  
Vol 90 (5) ◽  
pp. 3299-3306 ◽  
Author(s):  
Dian Huang ◽  
Kevin A. Leslie ◽  
Daniel Guest ◽  
Olga Yeshcheulova ◽  
Irena J. Roy ◽  
...  
2021 ◽  
Vol 11 (13) ◽  
pp. 5787
Author(s):  
Toan-Thang Vu ◽  
Thanh-Tung Vu ◽  
Van-Doanh Tran ◽  
Thanh-Dong Nguyen ◽  
Ngoc-Tam Bui

The measurement speed and measurement accuracy of a displacement measuring interferometer are key parameters. To verify these parameters, a fast and high-accuracy motion is required. However, the displacement induced by a mechanical actuator generates disadvantageous features, such as slow motion, hysteresis, distortion, and vibration. This paper proposes a new method for a nonmechanical high-speed motion using an electro-optic modulator (EOM). The method is based on the principle that all displacement measuring interferometers measure the phase change to calculate the displacement. This means that the EOM can be used to accurately generate phase change rather than a mechanical actuator. The proposed method is then validated by placing the EOM into an arm of a frequency modulation interferometer. By using two lock-in amplifiers, the phase change in an EOM and, hence, the corresponding virtual displacement could be measured by the interferometer. The measurement showed that the system could achieve a displacement at 20 kHz, a speed of 6.08 mm/s, and a displacement noise level < 100 pm//√Hz above 2 kHz. The proposed virtual displacement can be applied to determine both the measurement speed and accuracy of displacement measuring interferometers, such as homodyne interferometers, heterodyne interferometers, and frequency modulated interferometers.


2011 ◽  
Vol 36 (2) ◽  
pp. 148 ◽  
Author(s):  
Moonseok Kim ◽  
Youngwoon Choi ◽  
Christopher Fang-Yen ◽  
Yongjin Sung ◽  
Ramachandra R. Dasari ◽  
...  

ACS Nano ◽  
2013 ◽  
Vol 7 (12) ◽  
pp. 11174-11182 ◽  
Author(s):  
Jennifer Pascal ◽  
Carlee E. Ashley ◽  
Zhihui Wang ◽  
Terisse A. Brocato ◽  
Joseph D. Butner ◽  
...  

2005 ◽  
Vol 6-8 ◽  
pp. 805-808
Author(s):  
F. Sekine

The blanking of thin sheet metals using progressive dies is an important process on production of precision electronic machine parts. As a model of IC leadframe, an I-shaped and an Lshaped models were blanked and influences of blanking conditions on dimensional accuracy of blanked lead were examined. Furthermore, a mechanical model is proposed to explain the affect of the blanking conditions on product accuracy. In these days, more fine leads are required as electronic machines become more precise and accurate. It must be treated that leads are firmly held for blanking leadframes accurately. In this paper, an effective method of stripper holding leads strongly are discussed and a new method using newly designed stripper is proposed. Consequently the effect of it on lead accuracy is proved.


2021 ◽  
Author(s):  
Alice Sandmeyer ◽  
Lili Wang ◽  
Wolfgang Hübner ◽  
Marcel Müller ◽  
Benjamin Chen ◽  
...  

1999 ◽  
Vol 121 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Teng Guilan ◽  
Fu Haibo ◽  
Zhou Weiyi

Severe vibration and poor positioning accuracy may occur in an indexing cam mechanism operating at a high speed. Torque fluctuation of the input shaft and the resulting fluctuation of kinetic energy of the mechanism may be the major cause of the vibration. In this paper a method is proposed to minimize the fluctuation by using a so-called “speed-varying flywheel” that produces an opposite kinetic energy fluctuation that can counteract the effect of the energy fluctuation. The flywheel is installed on the output shaft of an additional cam-linkage mechanism. The parameter of the cam-linkage mechanism is optimized. An example is given to demonstrate the effectiveness of this method.


Measurement ◽  
2012 ◽  
Vol 45 (8) ◽  
pp. 2135-2140 ◽  
Author(s):  
B. Davoodi ◽  
H. Hosseinzadeh

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